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» LymeNet Flash » Questions and Discussion » Medical Questions » Hydroxy B12 vs. Methyl B12 (injections)

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Author Topic: Hydroxy B12 vs. Methyl B12 (injections)
Tammy N.
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I don't feel right when taking the Methyl B12. Razzle has suggested that maybe it's jump-starting methylation too quickly. I'm about to give the hydroxy a try.

I've read neff and others say that they take the hydroxy. Wonder what the reasoning is?

I understand the Cyan is not good.

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karenl
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Tammy you definitely need Hydroxy and Deplin, you have the mutation. No other folate and only the brand.
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delljen
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I take hydroxy B12 called Perque. I have been the simplified protocol for about 4 months and I feel it is helping my detox issues.

I did have problems in the beginning of the simplified protocol because I was not able to handle so many methyl groups. I felt terrible when I was on Methyl-B12. It gave me this over-methyl sick feeling and I then had to take no-flush niacin to counteract the sick feeling which really helped. If that makes any sense, ha (foggy brain)

Now that I have switched to hydroxyB12 I have not had those problems.

--------------------
Lyme, Bart, Babs D, FL1953
I am just sharing my thoughts and experiences - I'm not a medical professional.

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Tammy N.
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karen - I've been taking L-5-methyltetrahydrofolate (FaloPro from Metagenics). It is the methylated version of folate. Why do you think Deplin is better? Thanks. Also, do you know why Hydroxy is better?

dell - looks like we have a few things in common! haha. I'm hoping, like you, I'll do just fine with the hydroxy version. May I ask... what else are you doing as part of the simplified protocol? Did you have any testing done? If so, where?

btw - I would not have known that no-flush niacin would help with that sick over-methylated feeling. Where did you learn that?

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delljen
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Tammy, We do have a lot in common : )
I was tested through Dr. L on MTHFR.net
I came back;
C677T Heterozygous
A1298C Heterozygous

I know about no-flush niacin from working with Dr. L but here is a link that explains it:
http://mthfr.net/methylfolate-side-effects/2012/03/01/

I am on: Folapro, P5P, B4, Hydroxy B12 (perque), Intrinsic B12/Folate, Seeking Health Multi. Niacin as needed.
Rich's Simplified Protocol info link:
http://www.ei-resource.org/articles/chronic-fatigue-syndrome-articles/simple-methylation-treatment-protocol-for-chronic-fatigue-syndrome/

--------------------
Lyme, Bart, Babs D, FL1953
I am just sharing my thoughts and experiences - I'm not a medical professional.

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Razzle
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The key is to start slowly. For example, 1/4 of a tablet of the methyl-folate (5-methyltetrahydrofolate) once every few days.

Because if methylation has been stuck, getting it working again can release a flood of toxins and make a person feel absolutely miserable.

Good to know about the niacin (no flush) helping with the over-methylation. Thanks!

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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karenl
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Tammy,
I think the folapro is ok, just another brand.
The hydroxy is easier to be metabolized if you have the mutation. Your body is able to take it but can't metabolize the methyl at the moment. Honestly nobody could give me a real answer.
The hydroxy will make you feel great. One shot a day?
Tammy, you have only the 1298 not the 677, right?
One 1298 is not so bad.

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Tammy N.
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delljen - Thanks for that info. And good to know about the niacin trick too! Thanks. Some of the supps sound great, but others sound like they are a little contra-indicated for those with methylation issues. Like for instance, I thought we weren't suppose to take any folate, only the methylated version. Also, cyan b12 is not suppose to be good.... I thought only hydroxy or methyl.

Razzle - I've been taking 1/2 FaloPro tablet every day for the last 2 weeks, and feeling good. But maybe I should back off a bit. I don't want to overdo it.

karenl - doc said to start with 1 shot per week. But that doesn't seem like enough. Maybe I'll increase gradually. I was told I am homozygous for MTHFR. But I'm not sure what the gene numbers are. I couldn't find it on the report. I think I'll call the lab.

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Annelet
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Tammy..... people tolerate Methyl donors differently depending on their COMT/VDR status as well as the MTHFR mutations. If you get the full Methylation gene test done, this will become clearer.
Methylation is MUCH more than MTHFR

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Tammy N.
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Thank you Annelet. Yes, I understand there is so much more to it than just MTHFR. I'm just trying to figure out what the best possible lab would be, before I spend more money. I just saw your post on my other thread also. Thanks:)
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Hailex
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What is MTHFR? I'm a newbie.
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Tammy N.
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Check out MTHFR.net. This site will give you a good overview.

But like Annelet was saying, there is so much more to methylation issues than just MTHFR. To learn more on methylation, go to heartfixer.com. It's a lot to take in, but worth exploring.

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nefferdun
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I am COMT positive so I have "too many methyl groups floating around" according to heartfixer. It is best for me to take hydroxy B12 for that reason. Heartfixer explains it best:

he downside of being COMT (+) is that you will have a lot of free methyl groups floating around, as you are not using them up breaking down dopamine.

Thus if we need to give you other Methyl Cycle intermediates (such as methyl-B12 if you have MTR/MTRR issues), we risk ODing you with methyl groups. Too many methyl groups can lead to mood swings. Panic attacks and bi-polar mood disorder are seen with greater frequency in COMT (+) individuals; this makes sense.

--------------------
old joke: idiopathic means the patient is pathological and the the doctor is an idiot

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Razzle
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What Nefferdun says is true, unless one also has VDR variants (I have both ComT and VDR variants...they cancel each other out when it comes to methyl group tolerance, so I can take methyl-B12 without trouble).

Tammy,

If you are doing well on your current supplementing routine, then there is no need to back off. Let your symptoms guide you.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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