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» LymeNet Flash » Questions and Discussion » Medical Questions » "Methylation Problems Lead to 100's of Diseases" by Suzy Cohen

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Author Topic: "Methylation Problems Lead to 100's of Diseases" by Suzy Cohen
Dekrator48
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Great article!

http://www.dearpharmacist.com/2013/08/08/2394/

--------------------
The fibromyalgia I've had for 29 years was an undiagnosed Lyme symptom.

"For I know the plans I have for you", declares the Lord, "plans to prosper you and not to harm you, plans to give you hope and a future". -Jeremiah 29:11

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birdie67
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Just read this, very good article. Methylation is so complicated, but I believe it to be a big reason why some of us get and stay sick.
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ukcarry
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Thanks very much, Detraktor48: this great article is easily the clearest and most informative I have read in one place on the subject.
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MannaMe
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Thank you! I've got some people who will want to read this info.
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Tammy N.
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Excellent article! With great links for additional information/videos, etc.

Thanks for sharing.

I think this is perhaps my biggest underlying issue. I've known about it for some time, but still want to learn more.

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Dekrator48
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I agree with all of you that this is the most comprehensive article I've read, and it is understandable.

I love how she gives the links for the MTHFR site and 23andme, etc.

I think it would be helpful if this article were included in a permanent topic at the top of the board somewhere.

I suspect that there are lots of people who don't know they have methylation problems, and would respond better to treatment and detox if it were addressed properly.

--------------------
The fibromyalgia I've had for 29 years was an undiagnosed Lyme symptom.

"For I know the plans I have for you", declares the Lord, "plans to prosper you and not to harm you, plans to give you hope and a future". -Jeremiah 29:11

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Lymetoo
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Many with MTHFR are being helped over here:

https://www.facebook.com/#!/groups/MagnesiumAdvocacy/

--------------------
--Lymetutu--
Opinions, not medical advice!

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Tincup
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Yes, good info! Thanks!

[Big Grin]

BTW- Those with MTHFR- might want to write up YOUR test results and share them with your siblings and kids if you have any. They may want to be tested to help themselves in the future if they run into problems.

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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lax mom
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Has anyone been helped by any of the MTHFR practitioners on the MTHFRsupport website?

--------------------
♥ ♥ ♥ ♥ ♥
(aperture)
http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=115161;p=0

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beths
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My only concern is that we don't really know alot about how much the MTHFR expression actually affects us-especially if 60% of the population has it. Detoxing is very important-and I know many with lyme and Co have the MTHFR gene-but so does the average person.

I don't see any harm in taking the active form of B12 and folate-but as to the other issues...I have apparently the gene which blocks the conversion of sulfur.
According to the folks at MTHFR I should avoid all sulfur foods and drugs.
Except the first go round I got into remission by taking bactrim (a sulfa drug) for a very looong time)

It's always a little concerning when only 1 or 2 people are studying it- (Amy Yasko and those on the MTHFR board). And most of the supps are sold by Dr Yasko.

I know many parents of autistic kids have followed the protocol-and nothing changed.

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CD57
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I have been taking the B vitamins for a long time -- have MTHFR 1298C -- haven't noticed a difference. I wonder about this also.
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surprise
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We have been through a lot of autism protocols with my daughter.

Yasko, while wickedly brilliant in her own right, some of her papers have been very enlightening along our path, like excessive glutamate in the brain, etc.

does sell an extremely expensive (VERY) supplement line, detailed heavy years long path- also, minimal results heeded,

except in the instances of severely affected no speech children, after MB12 shots some language has ensued, in some cases.

What is perplexing to me: nailing down 200 mg folate a day, 200 mg P5P (B6) exactly 1,000 MB12, or whatever you get tailored for-

EXCEPT: what if you eat a piece a bread that day? or a bowl of fortified rice? doesn't that throw the whole exact balance out of whack?

I understand the imperative of getting the body to raise it's glutathione levels- often almost always too low in infection driven people.

My daughter has double A1298c- her highly regarded autism Dr. at the time didn't think MTHFR protocol was necessary to go further into-

Just from what I've gathered, perhaps the C677T have more of an issue....

--------------------
Lyme positive PCR blood, and
positive Bartonella henselae Igenex, 2011.
low positive Fry biofilm test, 2012.
Update 7/16- After extensive treatments,
doing okay!

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ukcarry
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Is there anyone here who really HAS been helped by methylation supplements then?
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Razzle
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My Brother and I both have seen improvements with methylation supplements.

Me: Sulfite sensitivity reactions for me are systemic and severe (anaphylactoid), but with Methyl-B12, Molybdenum and an antihistamine, I can avoid an Epi Pen shot and a trip to the ER.

My Brother says his sleep is better on the methylfolate and B12. That's an accomplishment, cuz he has had severe sleep problems for a long, long time (he does not have Lyme).

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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MannaMe
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My husband has the 677 mutation. He has noticed he is detoxifying better since he started supplements.

It is a balancing act, as he is still trying to treat the Lyme & Babs while at the same time eliminate the excess toxins. His mutation is the one where they don't detoxify very well.

He was beginning to feel more and more toxic with Lyme & co treatment and had to back down on abx. He's only doing herbals at this point.

We haven't seen dramatic results yet, but he is doing better than he was before he started MTHFR supplements.

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Blank
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Excellent article thank you for the post. I for one am implementing the MTHFR protocol after testing an found homogeneous for defect. I have always thought all along that there was some kind of genetic link because my sister, mother, and I have not responded very well to years of treatment with some of the top doctors in the country. I have also seen so many similarities of having taking additional Folic acid in supplements and felt absolutely crappy. Feel toxic after rounds and rounds of detox products still. Is this the answer to wellness?? I believe every little piece of the puzzle you can fine tune in your health may lead to a better outcome for treatment. Still treating fungal, metals, viruses,lyme, bab, you name it I have done it or still doing it. I will keep you all posted on progress....better to have hope than not.
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Dekrator48
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Bumping this up for anyone who has not seen it yet.

--------------------
The fibromyalgia I've had for 29 years was an undiagnosed Lyme symptom.

"For I know the plans I have for you", declares the Lord, "plans to prosper you and not to harm you, plans to give you hope and a future". -Jeremiah 29:11

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Jane2904
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Anyone with one copy of A1298C, do you have issues tolerating treatment, supplements etc.?

I have heard that Folate is not needed in large doses with this mutation.

Our daughter has this mutation and seems to have issues treating and detoxing.

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Razzle
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Yes. I have one copy of the A1298C MTHFR mutation and have many, many supplement, herb, food, drug, and environmental intolerances/allergies/sensitivities.

But I also have a double CBS mutation, and that I am sure is at least partially responsible for some of my sensitivity issues - especially sulfite sensitivity.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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Jane2904
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Interesting Razzle.

How did you find out about the CBS mutation?

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WPinVA
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thank you so, so much for sharing this! I learned some really valuable information.
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Razzle
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Jane2904,

I was given a link to Dr. Roberts' website:
http://www.heartfixer.com/AMRI-Nutrigenomics.htm

After reading this website dozens of times, I finally took the plunge and got tested through Dr. Yasko's lab:

http://www.holisticheal.com/health-tests/nutrigenomic-testing

I have no financial connections with anything listed in or linked to from within this post.

The test results from Dr. Yasko's tests showed me I had a double mutation for one of the CBS SNP's. Dr. Roberts' site (above) helped me understand more about what that meant.

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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Jane2904
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Razzle, thank you for the info.
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Thewino
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quote:
Originally posted by CD57:
I have been taking the B vitamins for a long time -- have MTHFR 1298C -- haven't noticed a difference. I wonder about this also.

I have the same genetic mutation. I have been taking Vitamin B-12 2,000mg twice daily for at least two years. It is a water soluble vitamin and your body will eliminate in your urine whatever extra dosages it doesn't need.

I'm not sure this mutation means a durn thing for me but my physician emailed that she wants to meet to discuss the lab results.

I certainly want to hear what she says. I hope she doesn't want to add more medications as I'm getting quite a list going.

My teachings for the day: the Vitamins to watch out for are: A, D, E, and K.

These are fat soluble so they are stored in your body and extra dosages are not immediately eliminated so it is much, much easier to take too much of these four vitamins.

Take care all,
TheWino

--------------------
Wrinkles only go where the smiles have been --J. Buffett

All of my replies should not be taken as medical advice as they are my opinions only and I am not a physician.

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