LymeNet Flash: Histamine receptors...Claritin H1R antagonist may not be enough

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Histamine receptors...Claritin H1R antagonist may not be enough

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Topic: Histamine receptors...Claritin H1R antagonist may not be enough

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

Histamine H1- and H4-receptor signaling ***cooperatively regulate*** MAPK activation

http://www.sciencedirect.com/science/article/pii/S0006295215006218

MAPK =

Mitogen-activated protein kinases (MAPK) are protein kinases that are specific to the amino acids serine, threonine, and tyrosine. MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group.

MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines.

They regulate cell functions including proliferation, gene expression, differentiation, mitosis, cell survival, and apoptosis (me = cell death).

Wikipedia

Look closely at H4R and Th17 cells (memory)...and the implication in "autoimmune" MS:

http://webcache.googleusercontent.com/search?q=cache:QgTdO8XHriwJ:http://etheses.dur.ac.uk/10651/ 2014

Though...

The ***role of histamine in autoimmunity*** and malignant disease through the *H1R* is well documented...

http://webcache.googleusercontent.com/search?q=cache:dL4-iEh-T80J:http://benthamopen.com/contents/pdf/TOIJ/TOIJ-2-9.pdf

Which histamine receptor(s) do we need to antagonize -

H1R, H2R, H3R, or H4R?

Read last sentence here:

http://europepmc.org/articles/pmc4151522

BTW...berberine impacts Th17 cells.

Very strange...rantinidine (+ bismuth citrate) can eliminate all forms of Bb *in the GI track* (Rx called Tritec).

Rantinidine is a *H2R antagonist.*

We know spirochetes have been found in the brains of those with AD...and the "latest" treatment involves another histamine receptor antagonist...

*a H3R antagonist.*

Infection triggered AD or infection + genetic predisposition?

http://webcache.googleusercontent.com/search?q=cache:u0PnGiaQb_kJ:http://www.miklossy.ch/media/Bb_AlzheimerJAD.pdf

Too little BH4 available - also needed to process ammonia. Each turn of the folate cycle produces one molecule of BH4.

Read just intro paragraph here:

http://webcache.googleusercontent.com/search?q=cache:-FPFGOlkFqMJ:http://europepmc.org/articles/pmc1027905/pdf/jnnpsyc00123-0086.pdf

Lyme disease-causing borreliae profit specifically from the broadly conserved ***tick histamine release factor (tHRF)***, and from cysteine-rich glycoproteins represented by Salp15 from Ixodes scapularis and Iric-1 from Ixodes ricinus ticks which they recruit to their outer surface protein C (OspC).

PMID:26352137 2015

Me...B6 + CBS (enzyme) -> cysteine -> taurine (lowers cholesterol = autism symptoms) + glutathione + sulfate in the transsulfuration pathway to lower homocysteine versus the "remethylation" pathway to lower homocysteine.

CBS upregulation and our gene types:

http://webcache.googleusercontent.com/search?q=cache:xMgi-Ta414MJ:http://geneticgenie.org/all-mutations/

"Tick histamine release factor is critical for Ixodes scapularis engorgement ***and transmission*** of the lyme disease agent.

These findings suggest that blocking tHRF might offer a viable strategy to complement ongoing efforts to develop vaccines to block tick feeding and transmission of tick-borne pathogens."

PMID:21124826 2010

High histamine levels, whatever the cause, increase one's proneness to allergies.

http://webcache.googleusercontent.com/search?q=cache:78WwGeNAmHQJ:http://www.arltma.com/Articles/AllergyDoc.htm

= "multiple chemical sensitivities"?

Garth N...

http://www.researchgate.net/publication/235918074_Chronic_Bacterial_and_Viral_Infections_in_Neurodegenerative_and_Neurobehavioral_Diseases

Underlying genetic differences AND subsequent exposure to pathogens may impact outcome, IMO.

Just as some persons may have an adverse reaction to a vaccine if their genetic profile differs from "normal" - perhaps:

http://www.ncbi.nlm.nih.gov/pubmed/17895626

So much for vaccines not possibly triggering autism in susceptible persons...

[ 09-21-2015, 01:59 PM: Message edited by: Marnie ]

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

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