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» LymeNet Flash » Questions and Discussion » Medical Questions » Serotonin Syndrome

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Author Topic: Serotonin Syndrome
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Has anyone had Serotonin Syndrome? If so how did you get rid of it?

I recently developed severe burning skin, high blood pressure, heart palpitations and my pupils were dilated. I went to the ER and was given an IV with lorazepam. It worked great, the skin burning went away and I felt so much better. After several days I has started to come back, even after I have stopped all meds.

This morning the Dr. gave me Periactin (cyproheptadine) which is supposed to help reduce Serotin. So far it has not helped.

Does anyone have any ideas?

'Come to me, all you who are weary and burdened, and I will give you rest.' Matthew 11:28

Posts: 2607 | From Hooterville | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
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Perhaps you are getting some answers now?? Have they identified which drug is causing it?

Here is info on treatments:

Opinions, not medical advice!

Posts: 94080 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
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Periactin should help but you should ask the doc for more lorazepam.

What did your serotonin syndrome feel like?

I think a person can get serotonin syndrome from antibiotics. I've never read that's true but I'm sure of it. When you're taking abx and you have gut issues the gut can start just pumping out a ton of serotonin. I think this happened to me when I was trying to treat myself.

Posts: 2057 | From Florida | Registered: Feb 2015  |  IP: Logged | Report this post to a Moderator
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MAO-A is needed to breakdown serotonin. With (genetically) low MAO-A = excess serotonin (and dopamine and norepinephrine).

Some persons can't handle SSRIs for depression because they have too little MAO-A and this -> excessive serotonin.

B2, riboflavin is needed to make MAO-A.

It works in synergy with P5P (active B6), Mg and Ca in a supplement by Now (brand) called P5P. One taken per day in the morning should help.

Remember years ago, a drug called Bendectin was used for the typical N/V of pregnancy (excess serotonin)...well, it was Pyridoxine/doxylamine.

For hyperemesis during pregnancy, sometimes docs use Zofran.


Pyridoxine is one form of B6.

Doxylamine succinate is in Unisom sleep tabs.

Here's the history of Bendectin - which is back on the market and been renamed (and is now timed release):

There is a complex interaction between substance P (neurokinin-1 )receptors and serotonin and norepinephrine.

Here is a link to the symptoms and some causes of serotonin syndrome:

Posts: 9393 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator

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