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» LymeNet Flash » Questions and Discussion » Medical Questions » IMPORTANT- Babesia duncani Treatment- Not Working

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Author Topic: IMPORTANT- Babesia duncani Treatment- Not Working
Tincup
Honored Contributor (10K+ posts)
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Quote- "Here, we report the first continuous in vitro culture of B. duncani in human red blood cells.

We show that during its asexual cycle within human erythrocytes, B. duncani develops and divides to form four daughter parasites with parasitemia doubling every ~22 h.

Using this in vitro culture assay, we found that B. duncani has low susceptibility to the four drugs recommended for treatment of human babesiosis, atovaquone, azithromycin, clindamycin and quinine, with IC50 values ranging between 500 nM and 20 μM.

These data suggest that current practices are of limited effect in treating the disease."

https://www.ncbi.nlm.nih.gov/pubmed/30463941

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Posts: 20075 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
bcb1200
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Yes. Betterhealthguy posted this a few days ago.

Coartem and Alinia are good options. Malarone too.

Herbal options as well. MC-Bab-2 etc

--------------------
Bite date ?
2/10 symptoms began
5/10 dx'd, after 3 months numerous test and doctors

IgM Igenex +/CDC +
+ 23/25, 30, 31, 34, 41, 83/93

Currently on:

Currently at around 80% +/- most days.

Posts: 3086 | From Massachusetts | Registered: May 2010  |  IP: Logged | Report this post to a Moderator
Brussels
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Is there anyone here that still don't know about pleomorphism?

I wonder which microbe is not pleomorphic, if such a thing actually exists....

I guess we got about 100 years of lies, making us believe that one microbe is always the same, like a monkey is always a monkey, and an elephant always an elephant.

The old model of one microbe = one drug treatment should be long gone, but some people still believe it.


You can guess that if researchers do not get babesia duncani IN VITRO dead with 4 antibiotics, adding 2, 3 more IN VIVO will probably not do the job either.

The only way out is to try to fix immune problems, cytokine cascades, etc together with antimicrobials that do not target the good microbes.

I'm finally reading the 2 last buhner books on coinfections, and he mentions antibiotic treatment as being 'simple treatments'.

He said something like 'I'm not against using simple treatments for bart or babesia such as antibiotics, but if they do not work, move to more complex treatments'.

Posts: 5887 | From Brussels | Registered: Oct 2007  |  IP: Logged | Report this post to a Moderator
mjo
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Just my opinion but I believe at some point babesia parasites become so overwhelming in the blood that treatment must include serious anticoagulants. Warfarin can help some, but the low molecular weight heparins are far better, based on experience.

And, with some calling "Quack!!" the more blood drawn, the better I would feel.

For more info check out Hughes Syndrome.

Posts: 416 | From Luck home | Registered: Sep 2005  |  IP: Logged | Report this post to a Moderator
nefferdun
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I began treatment for Babesia D. in 2010 with Zithro and Mepron. Five months later I had made no progress. I switched to Malarone with pulses of Coartem every three weeks. I felt the symptoms were gone in about 4 months.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4645 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
   

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