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» LymeNet Flash » Questions and Discussion » Medical Questions » 2019 a selenium protein

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Author Topic: 2019 a selenium protein
Marnie
Frequent Contributor (5K+ posts)
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The exact mechanisms that contribute to

depletion of B. burgdorferi upon

***selenoK knockdown***

is yet to be determined, but this study suggests that selenoK may play a vital role in the

survival of B. burgdorferi

***within the tick host.***


A qRT-PCR assay revealed the significant

***upregulation of selenogene K (selenoK) expression in B. burgdorferi-infected tick tissues.***

Silencing of the selenoK transcript significantly depleted B. burgdorferi copies

within the infected tick tissues.

Upon selenoK knockdown, another component of the ERAD complex, selenoprotein S (selenoS), was significantly upregulated, suggesting a compensatory mechanism to maintain ER homeostasis within the tick tissues. Knockdown of selenoK also

upregulated ER stress-related unfolded protein response (UPR) pathway components, ATF6 and EIF2.

https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3548-y


Selenoprotein K (knockdown = less Bb) is a novel target of m-calpain,
and cleavage is regulated by Toll-like receptor induced calpastatin in macrophages. J Biol Chem 286:34830–34838.

m-calpain is the type-protease for the C2 (calpain) family
Wikipedia

Selenoprotein K *deficiency* inhibits melanoma by

reducing calcium flux required for tumor growth and metastasis.

https://www.ncbi.nlm.nih.gov/pubmed/29568366

SELENOK is:
involved in ***macrophage uptake of low-density lipoprotein (LDL) and in foam cell formation***

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SELENOK

Inverse correlation between
gga-let-7f-3p and SELENOK levels

The target of SELENOK is gga-let-7f-3p.
https://www.ncbi.nlm.nih.gov/pubmed/29905752

While in the tick, Bb depends on the antioxidant effects of SelenoK/SelK

It does not want it's Osps "fried".

BOTH SelenoS and SelenoK happen as a result of ES/stress = free radicals happen.OVERextporession of SelK...not good.

SELENOK/SelK = Transmembrane protein localized to ER and involved in *calcium flux* in immune cells (remember silencing it reduces Bb)

SELENOS/SelS = Transmembrane protein found in plasma membrane and ER.

Reduces ER stress


http://webcache.googleusercontent.com/search?q=cache:wuCLuZgRDrEJ:epubs.surrey.ac.uk/845246/1/PhD%2520thesis%2520Matshediso%2520Zachariah%25202017.pdf+&cd=14&hl=en&ct=clnk&gl=us&cl ient=safari

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