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» LymeNet Flash » Questions and Discussion » Medical Questions » To Keebler

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Author Topic: To Keebler
Marnie
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I think I've got it.

We've known this for a long time:

Borrelia burgdorferi differs from many other bacteria in that it contains only two major membrane phospholipids:

phosphatidylglycerol (PG) and phosphatidylcholine (PC).


scientists from the National Centre for Biological Sciences (NCBS), Bangalore, and the Babraham Institute, Cambridge, UK have recently found a critical link – an enzyme named

***Phospholipase D or PLD*** – that is essential for proper recycling of membranes

to sustain normal sight.

Once triggered by light, however, rhodopsin molecules must be ‘reset’ in order to sense light again.

http://news.ncbs.res.in/press-release/ncbs-scientists-find-key-molecule-regulates-how-cells-maintain-size-their-surface

Soooo rhodopsin depends on a lot of PLD to be recycled so the WFL can see at night.


Phospholipase D’s principal substrate is

phosphatidylcholine (remember it is one of Bb's membranes)

***which PLD hydrolyzes ***

to produce the signal molecule phosphatidic acid (PA), and soluble choline.

(and remember Bb can't make PC)

Wikipedia

In fact, phosphatidylcholine (PC) is quantitively the most important source of DAG in many mammalian cells.

The finding that TUDCA induced a sustained and not a transient accumulation of DAG

as well as the lack of effect of TUDCA on hepatocellular IP3 levels thus suggests that the

TUDCA- induced DAG accumulation is mainly caused by

cleavage of PC

as mediated by the sequential activation of PLD and phosphatidic acid hydrolase.

https://tinyurl.com/yyqcchz3

[ 07-26-2019, 03:44 PM: Message edited by: Marnie ]

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Keebler
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Marnie,

Thanks so much for thinking of me. I'm a little crispy around the edges at this time with lawn crews out my window. Will read this later. Merci.
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Marnie
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I need also to update the above since Bb can apparently make PC via Phosphatidylcholine synthase.

Borrelia burgdorferi ***Requires Glycerol*** for Maximum Fitness During The Tick Phase of the Enzootic Cycle

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3131272/

Conversion of Phosphatidylcholine to Posphatidylglycerol with

***phospholipase D and Glycerol.***

https://www.ars.usda.gov/research/publications/publication/?seqNo115=202529

Insufficient PLD?

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Keebler
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Marnie, my brain just can't "go there" right now. I will still look at this but my brain dictates when I can read what.
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Keebler
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Finally, I think I read as much as I could from key parts but even when I'm in my best zone, it's a bit tricky.

I can't really verbalized my thoughts on the all of this.

Yet, the last link you posted though, what they are doing really causes me concern. It sounds dangerous to me, honestly, the industrialized manipulation of petroleum and seed oil (soybean) . . .

and as I've been studying elsewhere just how damaging even the seed oil on the supermarket shelves are for humans - this just seems alarming to me.

from the last link you posted:

https://www.ars.usda.gov/research/publications/publication/?seqNo115=202529

Excerpt:

Interpretive Summary:

Biodiesel is manufactured from fats and oils. A coproduct of biodiesel production is glycerol.

The recent expansion of biodiesel production facilities has led to a world-wide increase in glycerol, and means to use this glycerol for new products are now being sought.

We investigated the use of an enzyme called phospholipase D to produce a lubricant from glycerol and lecithin, a waste product of soybean oil production.

The lubricant has medical uses and may have industrial uses, too. Various commercial types of phospholipase D were tested, as well as different reaction conditions to find the best ways to synthesize the lubricant.

Using a new method to follow the production of lubricant, it was found that very high levels of the lubricant could be obtained by using one commercial preparation of phospholipase D.

This research will help to promote new uses both for glycerol and lecithin, and thus increasing the economic viability of producing materials from natural fats and oils.

(end excerpt).

"from natural fats and oils" ??? not the way they're doing it. I find this idea and industrialized process alarming in the context of how first, these are not at all "natural" by the time they've gone through all these industry processes.

I think they could be detrimental to the body. I'm looking at it from the history of the oil from cottonseed that was industrial waste and they thought - oh, hey, we'll call it canola oil and tell people to eat it and make a fortune.

Soybean oil is not at all a good idea, either.

That - and other "vegetable" oils that have been through chemical extraction and heat processes - well it's been very damaging to people. Next posts explain.

But, first, I don't think it's even a good idea to be using biodesiel from corn, etc. That changes into a toxic mix to make & burn fuel and that kind of air pollution from vehicle exhaust is causing a lot of disease.

Both fossil fuels and industrialized seed oil (including corn, soybean, etc.) can cause all kinds of trouble in certain forms whether just for vehicular fuel - or for cooking oil in the case of the latter.
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[ 07-30-2019, 03:47 PM: Message edited by: Keebler ]

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Keebler
Honored Contributor (25K+ posts)
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https://www.youtube.com/watch?v=v5_RO6Fgurw&t=3s

Nina Teicholz - Vegetable Oils: The Untold Story

34:55 video at YouTube . . . posted by Virta Health - Oct 31, 2018

Filmed at the Emerging Science of Carbohydrate Restriction and Nutritional Ketosis, Scientific Sessions at The Ohio State University


https://www.youtube.com/watch?v=KY8pq8GwLVo

Sinning with Seed Oils - are Vegetable Oils Healthy? Tucker Goodrich

Ivor Cummins podcast #10

2:13:55 video at YouTube

https://thefatemperor.com/wp-content/uploads/2019/03/Sinning-with-Seed-Oils-are-Vegetable-Oils-Healthy-Tucker-Goodrich-Podcast-10.pdf

Interview TRANSCRIPT for above video - 43-page pdf


https://www.youtube.com/watch?v=wPlHuXYI8v0

The Most Dangerous Cooking Oils in the World

10:11 video by Dr. Ken Berry - Feb 6, 2018


video notes: For the last few decades we've been duped into believing we can cook our food in chemically processed seed oils and continue to have good health.

Only now are we starting to understand that our health has suffered from this deception, whether the deception was intentional or not.

The cell-membrane of every single cell in your body is made of fat/cholesterol, so obviously you want to be putting the best fat possible into your body.

Putting an easily oxidized, inferior oil in your body leads directly to cell membranes that are much more susceptible to oxidative damage.

In this video I tell you the very worst and the very best cooking oils, so you can build your cell membranes of the best fat possible. It is vital to your good health and longevity...


https://www.youtube.com/watch?v=6ePOa7JPKBE

Why eating saturated fat won't kill you, but vegetable oil might.

Dr. Paul Mason - 28:34 video - Apr 25, 2019


https://www.youtube.com/watch?v=5VEjArG5RG8

Vegetable Oil - The Silent Killer w/ Dr. Cate Shanahan

1:04:47 video - Jan. 3, 2017

video note:

What is so destructive to the human body that Dave would rather smoke a cigarette than eat?

Vegetable oil. This kitchen staple found in almost every single home in the United States is slowly destroying the bodies of the American people on the cellular level.

On this episode, Dave welcomes Los Angeles Lakers nutritionist

Dr. Cate Shanahan onto the podcast to talk about the benefits of healthy animal-based fats and the destructive effects unleashed on the human body from their toxic cousins, vegetable oils.

Effects such as cellular degradation and mutation, destruction of the elasticity of skin, brain trauma, and even cellulite.
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[ 07-30-2019, 03:59 PM: Message edited by: Keebler ]

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