I think the article said that they are not sure how it works, but the drug had been used as an antimicrobial and antiparasitic back in the 40's I believe.
Posts: 180 | From ft. myers, florida | Registered: Apr 2004
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Dr Zhang released a study in April that looked at this.
quote:While the currently used drugs for treating bartonellosis, including rifampin, erythromycin, azithromycin, doxycycline, and ciprofloxacin, had very low minimal inhibitory concentration (MIC) against growing B. henselae, they had relatively poor activity against stationary phase B. henselae, except aminoglycosides.
Bartonella has a persister form, like Lyme, that current drugs are largely ineffective against.
Fortunately, there are a lot of FDA approved drugs that do work. We just haven't used them for Bartonella yet.
quote:The identified top drug candidates include pyrvinium pamoate, daptomycin, methylene blue, azole drugs (clotrimazole, miconazole, sulconazole, econazole, oxiconazole, butoconazole, bifonazole), aminoglycosides (gentamicin and streptomycin, amikacin, kanamycin), amifostine (Ethyol), antiviral Lopinavir/ritonavir, colistin, nitroxoline, nitrofurantoin, verteporfin, pentamidine, berberine, aprepitant, olsalazine, clinafloxacin, and clofoctol. Pyrvinium pamoate, daptomycin, methylene blue, clotrimazole, and gentamicin and streptomycin at their respective maximum drug concentration in serum (Cmax) had the capacity to completely eradicate stationary phase B. henselae after 3-day drug exposure in subculture studies.
[ 09-14-2019, 01:34 AM: Message edited by: Charles12 ]
Posts: 100 | From Virginia | Registered: Mar 2010
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