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» LymeNet Flash » Questions and Discussion » Medical Questions » Any new treatment for Bartonella?

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Author Topic: Any new treatment for Bartonella?
nefferdun
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This is my third time treating it with Bactrim DS. Maybe something else would be more effective.

I used Levaquin but it gave me tendonitis. I could not tolerate Rifampin - don't remember why.

Any other treatment?

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4666 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
no_lyme_in_florida
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The most talked about new treatment for Lyme quite possibly might target Bartonella.

Towards the bottom...

https://www.lymedisease.org/disulfiram-kinderlehrer/

Posts: 180 | From ft. myers, florida | Registered: Apr 2004  |  IP: Logged | Report this post to a Moderator
unsure445
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If Difulsuram hits Bartonella I may have to give it a go and call TBI's done. Just a few minor symptoms that come and go but they are definitely Bartonella.

Does anyone know by what mechanism Difulsuram works against TBI's? Maybe it was in the article and missed it, skimmed it over....

Thanks!

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unsure445

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no_lyme_in_florida
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I think the article said that they are not sure how it works, but the drug had been used as an antimicrobial and antiparasitic back in the 40's I believe.
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MissVictoria
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I made a lot of progress on Byron White Protocol For Bartonella
Posts: 211 | From New Jersey | Registered: Jan 2015  |  IP: Logged | Report this post to a Moderator
MannaMe
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A-BART from Byron White was helpful for my son.
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nefferdun
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Thank you for the information. I will look up Difulsuram.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

Posts: 4666 | From western Montana | Registered: Apr 2009  |  IP: Logged | Report this post to a Moderator
nefferdun
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Disulfiram sounds very promising. I don't see the LLND for two months. I would like to try it right now!

The Bactrim and Malarone are making me sick - I was vomiting today after I mowed the yard. I am so exhausted I can't do anything.

The last time I was on the same drugs for 9 months and it still didn't cure me.

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old joke: idiopathic means the patient is pathological and the the doctor is an idiot

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LisaK
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good luck!

Keep us posted on how t goes
[Smile]

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"The difference between stupidity and genius is that genius has its limits."

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Charles12
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Dr Zhang released a study in April that looked at this.

quote:
While the currently used drugs for treating bartonellosis, including rifampin, erythromycin, azithromycin, doxycycline, and ciprofloxacin, had very low minimal inhibitory concentration (MIC) against growing B. henselae, they had relatively poor activity against stationary phase B. henselae, except aminoglycosides.
Bartonella has a persister form, like Lyme, that current drugs are largely ineffective against.

Fortunately, there are a lot of FDA approved drugs that do work. We just haven't used them for Bartonella yet.

quote:
The identified top drug candidates include pyrvinium pamoate, daptomycin, methylene blue, azole drugs (clotrimazole, miconazole, sulconazole, econazole, oxiconazole, butoconazole, bifonazole), aminoglycosides (gentamicin and streptomycin, amikacin, kanamycin), amifostine (Ethyol), antiviral Lopinavir/ritonavir, colistin, nitroxoline, nitrofurantoin, verteporfin, pentamidine, berberine, aprepitant, olsalazine, clinafloxacin, and clofoctol. Pyrvinium pamoate, daptomycin, methylene blue, clotrimazole, and gentamicin and streptomycin at their respective maximum drug concentration in serum (Cmax) had the capacity to completely eradicate stationary phase B. henselae after 3-day drug exposure in subculture studies.


[ 09-14-2019, 01:34 AM: Message edited by: Charles12 ]

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