LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Chronic Lyme Disease: A Review

 - UBBFriend: Email this page to someone!    
Author Topic: Chronic Lyme Disease: A Review
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
I wish I had full access to this article:

http://www.sciencedirect.com/science?_ob=ArticleURL
&_udi=B75J9-4SD259B-G&_user=10&_coverDate=06%2F30%2F2008&_
rdoc=14&_fmt=high&_orig=browse&_srch=doc-info
(%23toc%2313145%232008%23999779997%23687987%23FLA%23display%23Volume)
&_cdi=13145&_sort=d&_docanchor=&_ct=16&_acct=C000050221&_version=1&
_urlVersion=0&_userid=10&md5=17edc88db651581634f1e115c5d6fb75

(couldn't post actual link because of "parenthesis in html tag", the previous in continuity is the full link address [Frown] )

Chronic Lyme Disease: A Review


Adriana Marques MD,
Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 10/11N234 10 Center Drive, Bethesda, MD 20892, USA

Available online 29 April 2008.


Studies have shown that most patients diagnosed with chronic Lyme disease either have no objective evidence of previous or current infection with Borrelia burgdorferi or are patients who should be classified as having post-Lyme disease syndrome, which is defined as continuing or relapsing nonspecific symptoms (such as fatigue, musculoskeletal pain, and cognitive complaints) in a patient previously treated for Lyme disease.

Despite extensive study, there is currently no clear evidence that post-Lyme disease syndrome is caused by persistent infection with B burgdorferi.

Four randomized placebo-controlled studies have shown that antibiotic therapy offers no sustained benefit to patients who have post-Lyme disease syndrome. ( WHAT?!!!! That's not what I've heard. I'd like to see the sources backing this statement)

These studies also showed a substantial placebo effect and a significant risk of treatment-related adverse events.

Further research to elucidate the mechanisms underlying persistent symptoms after Lyme disease and controlled trials of new approaches to the treatment and management of these patients are needed.


Article Outline

Chronic Lyme disease
Post-Lyme disease syndrome

The possible causes of post-Lyme disease symptoms
Studies of antibiotic treatment in post-Lyme disease syndrome

Summary
References

Table 1.

Experience of referral centers with patients suspected of Lyme disease

Table 2.

Symptoms after antibiotic therapy in patients with erythema migrans

Table 3.

Placebo-controlled, double-blinded randomized treatment studies in post-Lyme disease syndrome


Abbreviations: IV, intravenous; SF-36, Medical Outcomes Study 36-item Short-Form General Health Survey.


Infectious Disease Clinics of North America
Volume 22, Issue 2, June 2008, Pages 341-360
Tick-borne Diseases, Part I: Lyme Disease


Check out the other articles in this issue:

Infectious Disease Clinics of North America
Volume 22, Issue 2, Pages 195-380 (June 2008)
Tick-borne Diseases, Part I: Lyme Disease
Edited by Jonathan A. Edlow, MD
[Mad]


[Mad] [Eek!] [Mad]

[ 02. May 2008, 03:20 PM: Message edited by: AliG ]

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
BorreliaBrain
LymeNet Contributor
Member # 7603

Icon 1 posted      Profile for BorreliaBrain     Send New Private Message       Edit/Delete Post   Reply With Quote 
Oh this is just utter crap - this, people, is exactly how they are going to win - by defining us out of existence.

Please, I really wish every one of us would write to the editor of this journal and author of this piece.

And don't tell them a bunch of emotional stuff, just tell them that there is plenty of sound scientific evidence of persistant infection and that pieces like this will only contribute to patient suffering.

We have to take a stand against this publishing mania or we are in trouble. Write the journal, complain, scientists are just people, and they can be talked to. Sheeeeeesh [bonk]

Posts: 194 | Registered: Jul 2005  |  IP: Logged | Report this post to a Moderator
Lymen
Member
Member # 6882

Icon 1 posted      Profile for Lymen     Send New Private Message       Edit/Delete Post   Reply With Quote 
Why would anybody want to read this?

This is IDSA hogwash.

Posts: 98 | From BC | Registered: Feb 2005  |  IP: Logged | Report this post to a Moderator
lymie_in_md
Frequent Contributor (1K+ posts)
Member # 14197

Icon 1 posted      Profile for lymie_in_md     Send New Private Message       Edit/Delete Post   Reply With Quote 
Can we go even more on the offensive, such as write an article and get it published. I agree it should highlight the science, such as a recent study found mice retained lyme despite the IDSA prescribe abx. We could add Atty. Gen. Blumenthals discourse on the IDSA and their conflict of interest. It seems like we have weapons, how do we get it to the media?

--------------------
Bob

Posts: 2148 | From Maryland | Registered: Dec 2007  |  IP: Logged | Report this post to a Moderator
Greatcod
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
Well its all very tricky business. Technically, they guy is right. The few published double blinded studies, especially Klempner's, show no improvement after relatively short term (1-2 month)treatement.
I don't believe there are any published double blinded studies showing improvemet or remission with 6 or more months treatment. The evidence for effective long term treatment is largely anecdotal--ILADS doctors have positve results in tns of thousands of cases, but they were not studies--again ancedotal.
I have been trying to come up with the significant anecdotal evidence of success numbers, but no one, not ILADS or the LDA, has bothered to accumulate it. It is there, it is overwhelming, but the numbers have not been put together. So they beat us to death with Klempner. It is rather pathetic actually that the anecdotal numbers have not been accumulated. Only DR. D published a study, not double blinded, where he claimed 80% cured or signicantly improved.
So the "science" is on there side, the experiental evidence on ours.
As far as the comntinuing infection in animals, the IDSA argues that the volumne of the remaing spirochetes is too small to cause damage. I don't know how anyone measures that.

IP: Logged | Report this post to a Moderator
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
4 studies? I thought they only had 2 on relatively short-term IV Ceftriaxone (was it 12 weeks?).
I must have missed a couple of recent ones, I guess. [bonk]

Maybe it's just my present state of brain fog. [dizzy]

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
adamm
Unregistered


Icon 13 posted            Edit/Delete Post   Reply With Quote 
Or maybe it's their present state of lying through their teeth.
IP: Logged | Report this post to a Moderator
shazdancer
Frequent Contributor (1K+ posts)
Member # 1436

Icon 1 posted      Profile for shazdancer     Send New Private Message       Edit/Delete Post   Reply With Quote 
Klempner's study, 2001 -- selected patients who had already failed 30 days of IV ceftriaxone and gave them 30 days of IV ceftriaxone plus 60 days of oral doxycycline. They failed again.

Krupp's study, 2003 -- (abstract only) selected patients who still had severe fatigue and cognitive problems and gave them 28 days of IV ceftriaxone. Fatigue improved, cognitive problems did not in the long term, therefore he felt that IV was too dangerous for the results obtained.

Fallon's study, 2007 -- (abstract only) selected patients with severe fatigue, pain, and cognitive symptoms, and former treatment failure (30 days of IV), gave them 100 days of IV. Short-term improvement in cognition was observed after treatment, but it was not sustained over the long term. Pain and physical function did remain improved over the long term.

Posts: 1558 | From the Berkshires | Registered: Jul 2001  |  IP: Logged | Report this post to a Moderator
lou
Frequent Contributor (5K+ posts)
Member # 81

Icon 1 posted      Profile for lou     Send New Private Message       Edit/Delete Post   Reply With Quote 
NIH has consistently failed to do honest science in lyme disease. This latest article is just one in a long string of lies and malfeasance. I hope that the whole Bethesda campus is not doing business this way. Just think, there are 18,000 NIHers there. Our govt is costing a lot for public health. Are we getting our money's worth?

I personally blame Tony Fauci who is rolling in money because of AIDS (which they haven't cured or found a vaccine for) and biowarfare (to defend us against terrorists, when the only bio incident was probably caused by a govt scientist smuggling out some anthrax and mailing it.)

Posts: 8430 | From Not available | Registered: Oct 2000  |  IP: Logged | Report this post to a Moderator
Greatcod
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
Here's one more that IDSA cites. I think the only people who even read the Lyme literature are a few researchers and lots of Lymies.



34. Kaplan RF, Trevino RP, Johnson GP, et al. Cognitive function in post-treatment Lyme disease: do additional antibiotics help? Neurology 2003;60:1916-1922. [Free Full Text]

IP: Logged | Report this post to a Moderator
BorreliaBrain
LymeNet Contributor
Member # 7603

Icon 1 posted      Profile for BorreliaBrain     Send New Private Message       Edit/Delete Post   Reply With Quote 
Yes, we can write an article, or many articles, but no mainstream journal will touch them while this 'no chronic Lyme' nonsense is still in vogue. We've got to reach these journal editors and ask them to re-review or referee their articles.

For instance, they love to say that "no placebo controlled study found benefit to long term abx" - but that's simply not true. Of the four studies, three of them show improvement in pain and fatigue. HOW is that 'no benefit'?

We HAVE to fight back against publishing bogus science. We need to rebutt and refute these articles - and I am not above threatening legal action against these journals for publishing pure b.s., either. Sorry, but scientific malfeasance makes me maaaaaaadddddddddddddd. [Mad]

Posts: 194 | Registered: Jul 2005  |  IP: Logged | Report this post to a Moderator
InADaze
LymeNet Contributor
Member # 7711

Icon 1 posted      Profile for InADaze     Send New Private Message       Edit/Delete Post   Reply With Quote 
These type of studies make me cry. And make me mad, since I'm too Lyme fogged to read & understand them to tear them apart.

But, as someone who's had Lyme for years (even despite treatment) it makes me crazy to see "science" disproving my reality. Are there any studies out there or in the works that will show our side?

Posts: 168 | From Delaware | Registered: Aug 2005  |  IP: Logged | Report this post to a Moderator
bettyg
Unregistered


Icon 13 posted            Edit/Delete Post   Reply With Quote 
ali, thx for finding this and posting for us all.

surely several of our members have access to the full article as you requested...please post it IF you do; we thank you! [group hug] [kiss]

IP: Logged | Report this post to a Moderator
lou
Frequent Contributor (5K+ posts)
Member # 81

Icon 1 posted      Profile for lou     Send New Private Message       Edit/Delete Post   Reply With Quote 
What those studies proved was that lyme is chronic and the optimum treatment not yet known, however patients who are on longterm treatment to improve quality of life do improve for the most part. And some reach remission. No study yet that builds on clinical experience.

Basically we are being punished twice. First they fail to diagnose it early, then they refuse treatment that will help most chronic cases. This is a medical disaster and a failure. And there must be a lot of ignorant/arrogant/greedy people in medicine for a thing like this to go on for so long. And it aint the only one....look at autism, etc.

Posts: 8430 | From Not available | Registered: Oct 2000  |  IP: Logged | Report this post to a Moderator
cjnelson
LymeNet Contributor
Member # 12928

Icon 1 posted      Profile for cjnelson     Send New Private Message       Edit/Delete Post   Reply With Quote 
why cant we appeal to ILADS and go through them to the LLMD's and generate the numbers? They are the direct link!

Guys - this CAN be done - simply need to REDIRECT efforts - instead of griping about it all - send requests to ILADS and directly to your own LLMD. FLOOD THEM ALL AND DONT STOP!

Each LLMD has administrative employees. It CAN be done! And it can be done timely if began today!!!!

--------------------
Seeking renewed health & vitality.
---------------------------------
Do not take anything I say as medical advice - I am NOT a dr!

Posts: 830 | From TN | Registered: Aug 2007  |  IP: Logged | Report this post to a Moderator
8man12
LymeNet Contributor
Member # 7664

Icon 1 posted      Profile for 8man12     Send New Private Message       Edit/Delete Post   Reply With Quote 
Wonder if the worm,thought he only had PLS,If he would take a steriod shot.

What is there stance on this?
I know many who had plenty of treatment according to there guidlines,got a steriod shot,and got seriously worse,1 even died a few months later.

How do they explain this?
And twitches which are something that is irritating the nervous system.

Been doing great...HOMEmade colloidal silver.
Watch the coloidal silver videos on youtube.
You can even learn to make it there.
ONLY take homemade silver.
Arteminisinin...and Adriographis

Posts: 510 | From NEVERLAND.USA | Registered: Jul 2005  |  IP: Logged | Report this post to a Moderator
AliG
Frequent Contributor (1K+ posts)
Member # 9734

Icon 1 posted      Profile for AliG     Send New Private Message       Edit/Delete Post   Reply With Quote 
cj-
I do believe that Dr.B HAS implemented a data collection system with the ILADS LLMDs. I believe he is compiling Sx/Tx response data. [Big Grin]

I'm not sure when he started compiling it though. It would be wonderful if he could publish something about the compilation WHILE this review process is going on. Perhaps even better, present the info at the IDSA internet live broadcast hearings!!!!!

Now THAT would be something worth watching!!!!!! [Wink]

--------------------
Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner.

Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006  |  IP: Logged | Report this post to a Moderator
Greatcod
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
I couldn't agree more..I feel it would make a major difference in how the Lyme treatment dispute is resolved.
IP: Logged | Report this post to a Moderator
jamescase20
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
Lou you sure are right. I think really what this is showing is that our govt is sold to the highest bidder. Note, Aids also suffered things strongly related to lyme, and aids and lyme both came about around the same time period. I think we have been sold.
IP: Logged | Report this post to a Moderator
shazdancer
Frequent Contributor (1K+ posts)
Member # 1436

Icon 1 posted      Profile for shazdancer     Send New Private Message       Edit/Delete Post   Reply With Quote 
Greatcod, thanks for the 4th study.

Ali, I believe Dr. B just got started last fall, because he was recruiting docs at the last ILADS conference.

Posts: 1558 | From the Berkshires | Registered: Jul 2001  |  IP: Logged | Report this post to a Moderator
pingpong
LymeNet Contributor
Member # 13706

Icon 1 posted      Profile for pingpong     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi Ali,

thanks for link on the 'worm' anguis in herba-snake in the grass...will read another day, but for now, for 'dirt ,on the worm, see kathleen dicksons website http://www.actionlyme.org, and her yahoo group, ''scilyme2; it'll take some time, but stuff of real import, taht prosecutors can use.

be well,

C.

--------------------
pingpong

Posts: 361 | From At the Pingpong Tournament | Registered: Oct 2007  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to the Terms and Conditions.

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.