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» LymeNet Flash » Questions and Discussion » Medical Questions » Fluoroquinolone cautions - Links set - UPDATES

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Author Topic: Fluoroquinolone cautions - Links set - UPDATES
Keebler
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FLUOROQUINOLONE Antibiotics

INFORMATIONAL LINKS . . . IMPORTANT NOTES & CONSIDERATIONS


http://en.wikipedia.org/wiki/Category:Fluoroquinolone_antibiotics

Category: Fluoroquinolone antibiotics - list of over 40 different pharmaceuticals.

also consider all the OTHER NAMES a drug goes by, and also the generics.

Some fly under two or three different names or "nick names" depending upon the pharmaceutical company.

-------------------------

http://www.nbcnews.com/health/health-news/fda-antibiotic-linked-nerve-damage-n316566

Video 2:30 - NBC News & WCNC - March 3, 2015

Levaquin linked to nerve damage, tendon rupture & deaths.

A North Carolina woman who suffered a series of extreme side effects from using Levaquin, joins the effort to pull the medication.

The FDA says more than 1,200 people have died, and almost 100,00 have suffered side effects from the drug.


For more recent news UPDATES, SCROLL DOWN to most recent post.
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[ 12-20-2018, 06:25 PM: Message edited by: Keebler ]

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Keebler
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Fluoroquinolone Antibiotics

Building upon this as a information THREAD to post when this topic comes up, so there is a collection of articles if anyone wants to learn more.

http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/131164?#000000

Topic: warning: Levaquin / Fluoroquinolones

smokingsky posted this most recent thread on 16 Feb. 2015. Good detail & links here, with personal experiences.


http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/131059?#000000

Topic: levaquin warnings

Ellen 101 posted more detail on 02 Feb. 2015 - with additional personal accounts. As Judie points out:

"The tendonitis problems sometimes don't even show up for a year. The body just starts breaking down one piece at a time."


http://flash.lymenet.org/scripts/ultimatebb.cgi/ubb/search/search_forum/1

LymeNet archives - search in Medical forum, subject line: 440 matches found
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Keebler
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http://articles.mercola.com/sites/articles/archive/2012/10/20/fluoroquinolones-side-effects.aspx

Fluoroquinolones: The Deadliest Antibiotics on the Market?

- by Joseph Mercola, DC - October 20, 2012

Includes:

. . . a 2001 study by Dr. Jay Cohen, the following reaction rates were documented . . . . [a very clear chart / graph here]
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Lymetoo
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The Flox Report (page 203 is about healing the tendon)
http://www.myquinstory.info/wp-content/uploads/2010/01/FLOX_REPORT_REV_11.pdf

TENDINOSIS
HAVE YOU BEEN FLOXED?
http://www.doctorschierling.com/blog/category/tendinosis

http://runnersconnect.net/running-injury-prevention/achilles-tendonitis-and-insertional-achilles-tendinopathy-in-runners/

K Laser
http://www.k-laserusa.com/

Pain X 2000 light bed
http://www.diomedics.com/

--------------------
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Opinions, not medical advice!

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WPinVA
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I personally hope they don't pull it from the market. We don't have enough antibiotics as it is that are effective, and for some, this may be the only class that will work against certain infections. It has been that way for me with my persistent sinus infections.

I do think that this class is overused. I think it should be used as a last resort. I think all patients should be told of all side effects and doctors should monitor them much more closely and pull it at the first sign of an issue.

I'm glad this issue is getting more attention. I just hope there's not an overreaction because this drug has worked for me when others did not and I personally would be a little despondent if it is pulled because I don't know how I would get rid of my next sinus infection.

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tonesg
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One of, among the many problems with fluoroquinolones, is that whether or not a person has a potentially devastating negative reaction is
determined by one's cumulative exposure. A person might be one pill away from being floxed, there is no way to know. Also, many times reactions are delayed, sometimes for months or years, so one may have gone beyond the threshold, and not know until it is too late.

The notion that being monitored by an MD while on the drug will somehow protect one from an adverse reaction or might mitigate a reaction, does not appear to be borne out by many people's experiences, including my own. There is nothing an MD can do, that will stop a reaction once it has started. In many cases, one dose of a fluoroquinolone has been enough to cause a severe reaction.

MD's have proven that they by and large are incapable of properly handling fluoroquinolones, and have failed to provide even a modicum of the caution and care one would expect when dealing with such a dangerous drug.

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Judie
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"One of, among the many problems with fluoroquinolones, is that whether or not a person has a potentially devastating negative reaction is
determined by one's cumulative exposure."

Yes, and as you said, some people have a devastating reaction when they've just taken 1 or 2 pills.

It doesn't help that LLMDs mistake the reaction for a herx even when you are being monitored.

My pain management clinic had no idea about fluoroquinolones and pain is their specialty. The doctors don't know anything that deal with this everyday, including the LLMDs.

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Keebler
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LymeToo just posted [in another thread] this article from this week's news:

http://wric.com/2015/04/21/8news-investigates-could-this-antibiotic-permanently-damage-your-health/

Cipro: Could this antibiotic permanently damage your health?

From WRIC News 8, the ABC affiliate in Richmond, VA - April 23, 2015 (updated)
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CherylSue
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I was given IV Levaquin fifteen years ago when I was hospitalized for a 103 fever I had for over a week. I was feeling badly to begin with, but after the IV my skin just burned and burned and my head was fried. I could barely see, move, or hear. Sounds bothered me. I was literally a zombie and didn't care if I lived or died.

It took me a year to "recover" from all types of neurological symptoms. I think initially I had lyme and babesia, but the Levaquin made it unbearable. Everytime I get a high fever I relapsed. Levaquin exacerbated Lyme and coinfections. Note I wasn't diagnosed with Lyme yet, and was not on any other abx.

I still have problems with fatigue today, although my Lyme symptoms have subsided.

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Keebler
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http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=130342;p=0

Judie posted on 25 October, 2014

Topic: 2013 FDA Warning about Fluoroquinolone antibiotics causing PERMANENT damage

Many excellent articles here
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Keebler
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http://floxiehope.com

FLOXIE HOPE

This site is to give HOPE to those who are suffering from Fluoroquinolone Toxicity Syndrome as a result of being poisoned by fluoroquinolone antibiotics – Cipro, Levaquin, Avelox, Floxin, etc.

It contains stories of healing.


http://www.survivingcipro.com/useful-information/glutathione-and-fluoroquinolone-toxicity-syndrome/

SURVIVING CIPRO - one woman's personal blog turned information sharing and discussion board.

A Guide to Fluoroquinolone Toxicity Syndrome and Finding a Cure

Treating Cipro, Levaquin and Avelox (moxifloxacin) Toxicity with Alternative Medicine
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[ 06-28-2016, 03:29 PM: Message edited by: Keebler ]

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Lymieloo
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Sadly, this stuff is being overused in so many cases, where it isn't even needed. It happened to me last year when I had pneumonia.

Of course by the time my illness got bad enough to see a doc, it was a weekend, so I went to the local prompt care clinic. The doc had my lungs x-rayed, since he couldn't hear pneumonia in them, saw that I indeed had it, and prescribed Levaquin.

I had bad reaction to it, so he changed it to something else, (funny, it seems like it was Doxy, but they wouldn't give that for pneumonia, would they?), which did nothing. Finally he gave me amoxy. and it worked fine. So there is no way that nasty stuff should have been used as the first line of defense!

It was after that I read the article on Dr. Mercola's site that is referenced above. Good grief!

--------------------
Bless the Lord, oh my soul. -- Psalm 103

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Keebler
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Judie just posted an important note in a different thread:

" . . . I got refloxed by a quinolone, you don't need the fluoride to be floxed. . . ." (end quote)
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Keebler
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Consider other ways to approach treatment. There are various options.

Explore D-Mannose as a support measure

&

http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=117755;p=0

RIFE Machine - Reference LINKS
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[ 06-28-2016, 02:58 PM: Message edited by: Keebler ]

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Keebler
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. . . aortic dissection . . . aneurysm . . . .

https://www.drugwatch.com/cipro-levaquin-avelox/

DRUG WATCH

Fluoroquinolones – Cipro, Levaquin & Avelox (over 40 in total)

Fluoroquinolones are the most used type of antibiotics in the United States. Over 26 million people received prescriptions each year.

But recent studies link these drugs to aortic dissection and aneurysm. Both conditions weaken the walls of the aorta, the largest blood vessel in the body, and may lead to a rupture or leak which can be life-threatening. . . . [More detail at link]

https://www.drugwatch.com/about/

DRUG WATCH - About this group
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[ 06-28-2016, 04:05 PM: Message edited by: Keebler ]

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Keebler
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A poster (if I recall correctly) once made a note that they were "floxed" by a Quinolone, too. Just reading the Contraindications, it seems that this could be Contraindicated in anyone with neurolyme, due to the CNS inflammation, alone.

[As with first learning about many topics, I find Wiki is a nice place to begin and I am thankful for their good work here. Of course, as with all encyclopedias of our youth, we then move on to other sources for further study.]

As best I can determine in basic phrasing (if I interpret this correctly) is that the difference in a Quinolone and a Fluoroquinolone is the generation - and the alteration described here along time:

https://en.wikipedia.org/wiki/Quinolone

Quinolone

Excerpts:

Pharmacology

The basic pharmacophore, or active structure, of the fluoroquinolone class is based upon the quinoline ring system.[51]

The addition of the fluorine atom at C6 distinguishes the successive-generation fluoroquinolones from the first-generation of quinolones.

The addition of the C6 fluorine atom has since been demonstrated not to be required for the antibacterial activity of this class (circa 1997).[52]

. . . Contraindications

Quinolones are contraindicated if a patient has epilepsy, QT prolongation, pre-existing CNS lesions, or CNS inflammation, or the patient has suffered a stroke.[17] . . . children . . . . etc.

First-generation [quinolones]

cinoxacin (Cinobac)

nalidixic acid (NegGram, Wintomylon)[77]

oxolinic acid (Uroxin)

piromidic acid (Panacid)

pipemidic acid (Dolcol)

rosoxacin (Eradacil)

[may be a partial list?]


[Second, third, fourth & "in development" fluoroquinolone lists here, too, but not the full lists as in the fluoroquinolone page.]
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Lymetoo
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I thought quinolone was short for fluoroquinolone. Guess not.

--------------------
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Keebler
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Drugs are always getting tweaked and - like kids going from elementary to middle school - when they do many often like to alter their names (or they have their names changed FOR them).
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Keebler
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In regard to the drug classification discussed above:

[Wiki] . . . The addition of the FLUORINE atom at C6 distinguishes the successive-generation fluoroquinolones from the first-generation of quinolones. . . .

https://en.wikipedia.org/wiki/Fluorine

Fluorine . . . Not to be confused with fluorene, fluorane, or fluoride. . . .


So, of interest to some, perhaps:

A post by LymeToo a couple weeks ago, led to all this:

http://www.slweb.org/ftrc.html

FLUORIDE Toxicity Research Collaborative -- Second Look’s increasing focus on the toxicity of

fluorides and fluorine

compounds and related health effects is largely the result of fluoride's ongoing “invisibility”. . . .


http://www.slweb.org/ftrcfluorinatedpharm.html

Index of Fluorinated Pharmaceuticals
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Keebler
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http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=1;t=134396;p=0

Chloroquine?

SickSam just posted this in the discussion at thread above.


"Judie, thanks for being persistent in saying that it is a quinolone. You caused me to dig deeper.

If you scroll down on the following link, there is a chart of these drugs that suggests that quinolines are, in fact, a subclass of quinolones" (end SickSam note)

http://www.biograph.be/concept/graph/C0033126/C0034428

Relations between Primaquine and Quinolones
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Keebler
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Bringing to the top, this vital point. Even if you are not taking this, please read & study so the detail will be with you.

Share with others, too.

Keep in mind that over FORTY different names / drugs are in this category.
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Keebler
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https://www.medscape.com/viewarticle/899142

FDA: Stronger Fluoroquinolone Warnings for Mental Health, Hypoglycemia

July 10, 2018

The US Food and Drug Administration (FDA) today ordered label changes for fluoroquinolones to strengthen warnings about the antibiotics' risks for mental health side effects and serious blood sugar disturbances, according to a press release. . . .

[Full detail at the link above]
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Keebler
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https://www.cnn.com/2018/12/20/health/antibiotics-aortic-aneurysm-cipro-levaquin-bn/index.html

[Fluoroquinolone category antibiotics]

Certain antibiotics may cause aortic aneurysm, FDA warns

By Jen Christensen, CNN - December 20, 2018

Excerpt:

The US Food and Drug Administration warned on Thursday that the benefits of fluoroquinolone antibiotics do not outweigh the risks -

- which include aortic aneurysm -- for certain patients, according to the latest research. The research is based on reports of patient problems and on studies published between 2015 and 2018.

Fluoroquinolone antibiotics are often used to treat serious respiratory infections, pneumonia, urinary tract infection, and even plague and exposure to anthrax.

They include drugs sold under the names

ciprofloxacin (Cipro),

gemifloxacin (Factive),

levofloxacin (Levaquin),

moxifloxacin (Avelox),

norfloxacin (Noroxin) and

ofloxacin (Floxin).

Patients take them orally or through injection.

The drugs may cause aortic aneurysm, a bulge in an artery that can grow and burst, causing dangerous or fatal bleeding.

Patients most at risk for an aortic aneurysm after taking these antibiotics are the elderly, those with high blood pressure,

people who have a history of blockages of the aorta or other blood vessels, and those who have genetic conditions like Marfan syndrome or Ehlers-Danlos syndrome. . . .

[Article continues at link above. Other sources should also be explored for more detail.]


http://en.wikipedia.org/wiki/Category:Fluoroquinolone_antibiotics

Category: Fluoroquinolone antibiotics - list of over 40 different pharmaceuticals.

also consider all the OTHER NAMES a drug goes by, and also the generics.

Some fly under two or three different names or "nick names" depending upon the pharmaceutical company.


And, keep in mind:

Judie posted a while back an important note in a different thread:

" . . . I got refloxed by a quinolone, you don't need the fluoride to be floxed. . . ." (end quote)
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[ 12-20-2018, 06:27 PM: Message edited by: Keebler ]

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