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» LymeNet Flash » Questions and Discussion » Medical Questions » autoimmune responses associated with antibiotic-refractory LA.

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Author Topic: autoimmune responses associated with antibiotic-refractory LA.
Marnie
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Do you still have infectious Bb or are you now autoimmune due to one particular antigen (a protein in Bb)?

T-Helper 17 Cell Cytokine Responses in Lyme Disease Correlate With Borrelia burgdorferi Antibodies During Early Infection
and With*** Autoantibodies*** Late in the Illness in Patients With Antibiotic-Refractory Lyme Arthritis.

Patients with Lyme disease often develop pronounced TH17 immune responses that may help control early infection.

However, late in the disease, excessive TH17 responses may be disadvantageous by contributing to autoimmune responses associated with antibiotic-refractory LA.

https://www.ncbi.nlm.nih.gov/pubmed/28077518 2017

The bile acid tauroursodeoxycholic acid (TUDCA), an inhibitor of cell stress (Kees- tra-Gounder et al., 2016; Xie et al., 2002), inhibited Th17 cell differentiation and counteracted the effect of hypoglycemia, osmotic stress, and hypoxia.

Not permitted to link on this website. Cut and paste and google the. first sentence to find it.


Th17 Cell-Associated Response to Borrelia Burgdorferi Outer Surface Protein A

https://dc.uwm.edu/etd/700/

OspA is linked to Bb's p66she protein - a stress regulator protein.

I wish I knew the dosage and timing of TUDCA (a bile salt conjugated with taurine) and which supplement company makes the best one.

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duncan
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Sorry, Marnie, no longer any such thing as abx-refractory LA if the new Guidelines remain unchallenged and unchanged. At least, that's how I understood it.

Evidently they are trying to rebrand it as post-antibiotic LA.

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Marnie
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Autoimmune Arthritides, Rheumatoid Arthritis, Psoriatic Arthritis, or Peripheral Spondyloarthropathy, Following Lyme Disease

https://www.ncbi.nlm.nih.gov/pubmed/27636905 2017

Or
https://www.medpagetoday.com/resource-centers/ra-pso-psa-related-disorders/systemic-autoimmune-joint-disease-may-follow-lyme-disease/1296

My sis is one dx'd with "autoimmune" post lyme. Oddly, her blood type is A.

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Marnie
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Pub med march 2019:


Biologic Markers of Antibiotic-Refractory Lyme Arthritis in Human: A Systematic Review.


CONCLUSION:
The evidence base of biologic markers for A-RLA is limited. However, a range of promising biomarkers have been identified.

Cytokines and chemokines related to Th17 pathway

together with a number of miRNAs species (miR-146a, miR-155 and let-7a) may be promising candidates in the prediction of A-RLA.

A panel of multiple biomarkers may yield clinically relevant prediction of the possible resistance at the time of LA first diagnosis.

https://www.ncbi.nlm.nih.gov/pubmed/30506261 MARCH 2019

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