Keebler
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- If at all possible, before even starting treatment for lyme or other TBD (tick-borne infections) . . .
PROBIOTICS are essential to help protect the gut flora, and also help prevent a systemic candida (yeast) infection that can result from antibiotics.
Keep apart from Rx by a couple hours, both directions of the clock.
This thread is not about probiotics but I wanted to be sure everyone knows this since I also intend this to be
good detail for the liver & kidney support that should be in place a couple hours before even that first antibiotic (for chronic cases). For an acute or new case of lyme, get the antibiotic first, and couple hours later, then start the liver support.
Lyme Disease Liver Dysfunction - More Common than Many Doctors Think.
by L Matthews -June 28, 2012
= = = = = = = = = = = = = = = = = = = = = =
In general (not lyme specific):
Tilltoson says (somewhere in his book) that if a person does not eat enough vegetables & fruits, it is impossible to be able to enable natural detoxification processes. The antioxidants + fiber are key.
However, for those on antibiotics (abx), a resulting candida (systemic yeast) infection requires avoid sugar, even in most fruits.
Dark Berries and Tart Apples may be okay for some folks, in small amounts AFTER a good meal, so that the natural sugars are not overwhelming and "feed" the yeast in the gut. For some, though, all fruits need to be avoided.
Antioxidants and good carbohydrates need to be mostly from vegetables, at every meal, even breakfast. The FIBER is as important as the nutrients.
Beyond that:
From ``The One Earth Herbal Sourcebook'' (Tillotson, et.al.)
[ 08-01-2014, 07:20 PM: Message edited by: Keebler ]
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Keebler
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- Certain INFECTIONS CAN DAMAGE THE LIVER. So, it's imperative that we have experts to guide us in how to effectively and assertively treat infections - as well as how to take care of ourselves (and our livers) during treatment.
See the Self-Care & Important "Rules" in Burrascano's set here:
& WHY you need an ILADS-educated, Lyme Literate Doctor (whether LLMD or LL ND, or both)
------------------------------------------
When considering herbal / nutritional / adjunct methods:
if at all possible - because each person & each case is different - it's best to consult with an ILADS-educated LL (lyme literate) doctor who has completed four years of post-graduate medical education in the field of herbal and nutritional medicine -
- and someone who is current with ILADS' research & presentations, past and present.
Many LL NDs incorporate antibiotics (depending upon the licensing laws in their state). Some LLMDs and LL NDs have good working relationships.
When possible, it's great to have both a LLMD and LL ND and even better when they have a long-standing professional relationship.
Integrative / Holistic M.D., etc. (Be aware that those in this category can have various levels of formal herbal &/or nutritional education, perhaps even just a short course. Do ask first.)
Links to many articles and books by holistic-minded LL doctors of various degrees who all have this basic approach in common:
Understanding of the importance of addressing the infection(s) fully head-on with specific measures from all corners of medicine;
knowing which supplements have direct impact, which are only support and which are both.
You can compare and contrast many approaches.
BASIC HERBAL EDUCATIONAL & SAFETY links, etc. -
[ 07-31-2012, 07:19 PM: Message edited by: Keebler ]
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Keebler
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Search LymeNet Archives for "Herx" or "Herxheimer"
There are many threads in both the Medical and General Forums.
Editing to add on June 17, 2016:
Thanks to TF just posted this in another thread today:
From Burrascano:
"Another very important factor is response to treatment- presence or absence of Jarisch Herxheimer-like reactions, the classic four-week cycle of waxing and waning of symptoms, and improvement with therapy." (page 7)
"Several days after the onset of appropriate antibiotic therapy, symptoms often flare due to lysis of the spirochetes with release of increased amount of antigenic material and possibly bacterial toxins.
This is referred to as a Jarisch Herxheimer-like reaction. Because it takes 48 to 72 hours of therapy to initiate bacterial killing, the Herxheimer reaction is therefore delayed.
This is unlike syphilis, in which these reactions can occur within hours.
It has been observed that symptoms will flare in cycles every four weeks. It is thought that this reflects the organism’s cell cycle, with the growth phase occurring once per month (intermittent growth is common in Borrelia species).
As antibiotics will only kill bacteria during their growth phase, therapy is designed to bracket at least one whole generation cycle. This is why the minimum treatment duration should be at least four weeks.
If the antibiotics are working, over time these flares will lessen in severity and duration. The very occurrence of ongoing monthly cycles indicates that living organisms are still present and that antibiotics should be continued.
With treatment, these monthly symptom flares are exaggerated and presumably represent recurrent Herxheimer-like reactions as Bb enters its vulnerable growth phase and then are lysed.
For unknown reasons, the worst occurs at the fourth week of treatment. Observation suggest that the more severe this reaction, the higher the germ load, and the more ill the patient.
In those with long-standing highly symptomatic disease who are on I.V. therapy, the week-four flare can be very severe, similar to a serum sickness reaction, and be associated with transient leucopenia and/or elevations in liver enzymes.
If this happens, decrease the dose temporarily, or interrupt treatment for several days, then resume with a lower dose. If you are able to continue or resume therapy, then patients continue to improve.
Those whose treatment is stopped and not restarted at this point usually will need retreatment in the future due to ongoing or recurrent symptoms because the infection was not eradicated.
Patients on I.V. therapy who have a strong reaction at the fourth week will need to continue parenteral antibiotics for several months, for when this monthly reaction finally lessens in severity, then oral or IM medications can be substituted.
Indeed, it is just this observation that guides the clinician in determining the endpoint of I.V. treatment." (p.17)
[End of TF's post] -
[ 06-21-2016, 06:12 AM: Message edited by: Keebler ]
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Keebler
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- Why should we avoid acetaminophen?
Because it can impair glutathione production and, therefore, curtail the ability of the liver to help remove metabolic waste and toxins, further stressing it.
Effective treatment relies on a good strong liver.
There have been several reports about it in the news over the years relating to liver damage, sometimes from even normal doses in otherwise healthy individuals.
. . . Even a single dose of acetaminophen can reduce the body's levels of glutathione, a peptide that helps repair oxidative damage that can drive inflammation in the airways, researchers have found. . . .
Tiny overdoses of Tylenol can add up to deadly damage
11-22-11
==============================
Make no mistake from the article title below, many (of not most) with lyme fall somewhere on the autism spectrum due to the way lyme affects sensory function, etc. This article is about lyme treatment and support but the title was arranged for a conference in Autism.
Exclusive: Dr. Lee Hieb explains why she's sworn off Tylenol
- by Lee Kieb, MD
Dr. Lee Hieb is an orthopaedic surgeon specializing in spinal surgery. She is past president of the Association of American Physicians and Surgeons, a free market medical organization.
Excerpts:
. . . Nearly ten years ago, an article was published in the journal Neurology looking at the risk of Alzheimer's in people taking anti-inflammatories. . . .
. . . It was found in the Neurology study that if you take an anti-inflammatory medication for two years, you decrease your risk of Alzheimer's by about 50 percent as compared to those people who took nothing.
This makes sense with what we know about Alzheimer's being partly an inflammation of the brain.
In the main section of the paper, the data also showed that people who took Tylenol for two years almost doubled their risk of developing Alzheimer's.
Interestingly, this finding - buried as it was deep in the body of the study - was not reported in the news release, nor mentioned in the abstract summary of the article (increased Christmas bonuses to the Tylenol PR people!), so most physicians have not heard of this troubling information.
The mechanism for this brain injury is not yet proven, but is thought to involve Tylenol's interaction with the NMDA receptor in brain cells.
The NMDA receptor regulates calcium channels that lead to excitation of nerve cells, and this so called ``excitotoxicity'' is probably one of the final common pathways for the development of Alzheimer's.
Lending further credence to this concern, recently there have been reports of acute memory loss in patients with only ten days exposure to Tylenol.
When this Tylenol induced memory loss happened recently to a neurologist, the doctor then began noticing the problem in his patients and now is bringing this to the attention of the medical establishment.
Fortunately, these acute memory losses have been reversible once the Tylenol has been removed.
Tylenol in the presence of alcohol poses a double whammy to the liver which may prove fatal. Alcohol consumption decreases glutathione in the liver - a potent detoxifying agent for Tylenol.
Combining alcohol with Tylenol can prove fatal even though the amount of Tylenol ingested is within the recommended dose limits.
This is magnified if the patient has been fasting, which further depletes glutathione. . . -
[ 02-12-2013, 02:10 PM: Message edited by: Keebler ]
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Keebler
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- Why does Ibuprofen pose a risk to the liver?
Because it can stress the kidneys and that adds to the work the liver has to take over, if at all possible.
Ibuprofen constricts blood flow. This can pose problems not just for kidneys but for the whole body.
National Kidney & Urulogic Diseases Information Clearinghouse (NKUDIC)
Analgesic Nephropathy (Painkillers and the Kidneys)
Excerpts:
. . . Analgesic use has been associated with two different forms of kidney damage: acute renal failure and a type of chronic kidney disease called analgesic nephropathy. . . .
. . . Some patient case reports have attributed incidents of sudden-onset acute kidney failure to the use of over-the-counter painkillers, including aspirin, ibuprofen, and naproxen sodium. . . .
. . . A second form of kidney damage, called analgesic nephropathy, can result from taking painkillers every day for several years. . . . .
. . . Ibuprofen may also increase the risk of chronic kidney damage, . . .
The popular pain reliever ibuprofen can cause kidney failure in people with mild kidney disease, according to a new study.
A three-year study on the drug was reported today in the journal Annals of Internal Medicine. . . .
. . . gave participants above-normal doses of 800 milligrams of ibuprofen three times a day - the equivalent of 12 ibuprofen tablets - for up to 11 days.
After eight days, three women developed kidney failure, which reversed when ibuprofen was discontinued. The remaining nine women, who received ibuprofen for 11 days, showed changes in kidney function but did not develop kidney failure.
After recovering, the three women were given 400 milligrams of ibuprofen three times a day, equivalent to normal doses of the drug.
Two of the three again developed kidney failure but recovered when the ibuprofen was stopped.
Ibuprofen relieves pain by interfering with the body's production of prostaglandin, a substance involved in inflammation. But at the same time, the drug constricts blood flow.
Normally, the change poses little risk if used for a short period.
But for those whose blood flow to the kidneys is already reduced by kidney, heart or liver damage, flu, or aging, ibuprofen could lead to acute kidney failure. . . .
Sadly, many sleep and pain meds can stress and even damage the liver. Always find out how any medicine you take will affect the liver & kidneys. Some choices:
[ 08-14-2012, 03:29 PM: Message edited by: Keebler ]
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Keebler
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- SYSTEMIC ENZYMES deserves some good space here.
This area is not my strong suit. Hopefully, CarolinPa or others who know more about this area will post. I think this is addressed above in the "Pain relief" thread.
[ 10-09-2012, 01:56 PM: Message edited by: Keebler ]
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- PARASITES & HEAVY METALS also deserve honored consideration in any liver care program.
I'm out of steam but will be back with a link to a parasite thread. glm111 (Gael) and GiGi have many posts about that topic
All I can do is mention heavy metals. That topic is just too complex for me to manage a basic link.
But do not ignore as many with lyme also deal with elevated levels of heavy metals and that can damage the liver, and other organs and functions, too.
GiGi and Marnie have good post in this area. -
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Keebler
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- PORPHYRIA, a metabolic dysfunction of the liver, involves the liver and the blood - and can affect the entire body and brain function. More about that here:
[ 01-20-2013, 06:35 PM: Message edited by: Keebler ]
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Keebler
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- LEMON WATER & SAVING YOUR TEETH: SWISH WATER
Lemon water is a popular "beverage" that some use to help the liver. Just a reminder so that teeth enamel can be spared.
Some think using a straw can help protect the teeth but - not really - as even the slightest bit of lemon water in the mouth can coat the teeth and gums. It's nearly impossible to get that lemon water from the straw straight down into the throat without any getting into the mouth.
And, besides, I want to ENJOY my lemonade. Fresh, organic lemon squeezed with a drop of stevia makes a wonderful beverage - hot or cold.
But, don't dump the lemon water as it has some great properties if one's stomach can handle the acid -
- just soon after enjoying, ALWAYS swish very thoroughly with clear water (maybe add touch of sea salt) afterward and then wait at least 30 minutes if it happens to be time to brush.
Really? Never Brush Your Teeth Immediately After a Meal Really?
By ANAHAD O'CONNOR - The New York Times - | May 21, 2012
THE FACTS
Is there ever a bad time to brush your teeth?
Most of us believe that proper dental care means flossing and brushing often -- at a minimum, twice daily, as the American Dental Association recommends. Those who are particularly diligent may brush more often, after meals, snacks or sugary drinks.
But research shows that brushing too soon after meals and drinks, especially those that are acidic, can do more harm than good.
Acid reflux poses a similar problem: While it might seem like a good idea to brush after a reflux episode, doing so can damage your teeth. Acid attacks the teeth, eroding enamel and the layer below it, called dentin.
Brushing can accelerate this process, said Dr. Howard R. Gamble, president of the Academy of General Dentistry. ``With brushing, you could actually push the acid deeper into the enamel and the dentin,'' he said.
In one study, a group of volunteers were followed for three weeks as researchers examined the impact of brushing on their teeth after they drank diet soda.
The scientists found an increase in dentin loss when brushing in the 20 minutes after drinking soda. But there was considerably less wear when brushing took place 30 or 60 minutes afterward.
``It is concluded that for protection of dentin surfaces,'' the authors wrote, ``at least 30 minutes should elapse before tooth brushing after an erosive attack.''
In the meantime, to get rid of acid, Dr. Gamble suggested rinsing the mouth out with water or using an acid-neutralizing mixture: one part baking soda, eight parts water.
THE BOTTOM LINE
Never brush immediately after an acidic meal or drink. Always wait at least 30 minutes. -
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Dietary Control. Controlling one’s weight by regulating fat intake and overall nutrition is very important. Limiting daily calories and avoiding foods high in saturated fat. Regular exercise is also important.
Anti-oxidant and Multiple Vitamins Supplement
Anti-hyperlipidemia Treatment: Many western anti-hyperlipidemia drugs are hard on the liver, so using alternative Chinese herbal remedies can be suitable for NASH.
By maintaining a healthy diet, the blood lipid level can be reduced along with fat deposits in the liver.
Facilitating bile secretion helps eliminate bile acid and reduce fat deposits in the liver.
Anti-fibrosis Treatment
Controlling liver inflammation and Facilitate Restoration of Liver Functions
Help heal liver inflammation and increase the liver's ability to metabolize fat and reduce accumulation -
[ 12-14-2016, 02:52 PM: Message edited by: Keebler ]
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- Even with the best support methods, antibiotics may be neither tolerable nor effective for everyone, all the time. Another avenue to consider:
posted
There's also liver tests that can show whether we have genetic difficulties detoxing - the detoxigenomic liver bloodtest via Genova Diagnostic Lab in NC is one of them, and Amy Lasko tests are others.
The info can help us and our LLMDs manage our detoxing protocol.
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- Lyme can cause liver fibrosis, so this is relevant. Most of the herbs here are those that only a ND would know, though:
COUNTERING THE SIDE EFFECTS OF MODERN MEDICAL THERAPIES WITH CHINESE HERBS
-by Subhuti Dharmananda, Ph.D -
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- A LL ND whom I had consulted told me Herxing can be very dangerous for the body and counterproductive. Best to stay just under the radar when possible to be kinder to the liver and kidneys.
Good support & habits can usually help the body be better able to tolerate treatment, gradually working up to therapeutic levels & tolerance but it's best not to push if herxing becomes too much.
Ellen101 just posted this at another thread:
While looking for info on herxing on bicillin I stumbled across this info and really thought it was informative.
At one point it explains how herxing may actually not be such a good thing.
" Pain management Md's have told me pain actually can weaken the immune system (see post regarding getting pain levels under control)
Herxing creates toxins, toxins create inflammation, inflammation can create autoimmune diseases and pain causing the immune system function to decrease even more"
I actually had a conversation with my LLNP about cyst busters, as to when to use them etc.
She said she does not use cyst busters - UNTIL - she feels symptoms are under control as to hit the body with too much at once will just be detrimental to the immune system.
(Ellen101) -
[ 10-01-2012, 03:59 PM: Message edited by: Keebler ]
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- Thanks to "girl" for posting this at another thread:
. . . Nettle leaf extracts reduce inflammation, in part, by suppressing the release of inflammatory cytokines.
They do this by blocking a chemical inducer known as NF-KappaB, which alters gene expresion. This may be one explanation for the beneficial efffects this herb has exhibited in rheumatoid arthritis (Riehemann et al., 1999). . . .
. . . its ability to slow down the inflammatory cytokine response caused by endotoxins. . . .
The Nature of Nettles - by Mary Jane Butters -
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- This just came up at another thread. Someone with pain in the liver area. For some reason, a good belly massage came to mind.
- Certain YOGA movements, gentle PILATES, Qi Gong or Tai Chi can help move some of the kinks, too.
Gentle belly massage (no deep poking or prodding unless first instructed where to push and where NOT to push).
WARMTH - A warm compress (with or without castor oil pack). Best to avoid electric heating pads and go for a hot water bottle, hot towel or a microwaved "corn" bag.
DEEP LAUGHTER THERAPY
SING or play a WIND INSTRUMENT
STROLL - slow meditative walk, settling on a certain rhythm and deep yet comfortable breathing cycles
See if you can find a professional in your area trained in VISCERAL MANIPULATION with
UPLEDGER INSTITUTE
or FELDENKRAIS (they can also help you assess Some good quality HOT teas - the real deal, GREEN TEA &/or TULSI TEA might be a very nice helper. Be sure the tea is from a reputable source (and that all their sources are top quality and fair trade).
A CUP OF TEA
Some good quality HOT teas - the real deal, GREEN TEA &/or TULSI TEA might be a very nice helper. Be sure the tea is from a reputable source (and that all their sources are top quality and fair trade).
Tea Kettles, TeaPots, and mugs should be certified LEAD-FREE and CADMIUM FREE. Chantal.com is just one place that carries such items. Emerson Creek Pottery & FiestaWare, too (both are made in USA). -
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- Toxicities - or even just "stimulating additives" in our food additives further stress adrenal function, the liver, kidneys, heart, brain and the entire body.
. . . XANAX . . . depletes the body of essential vitamins, minerals, melatonin and glutathione (the body's master antioxidant). . . .
. . . Benzodiazepines deplete approximately 50% of the glutathione from the white blood cells within five hours, and these cells defend our body from infection and foreign material.
This may explain why prolonged use of benzodiazepines can severely compromise our health. Dr. Jimmy Gutman describes Glutathione as ``Food for the Immune System.''
Replenishing the body of critical Glutathione levels not only helps to improve immune function, but also allows the body to detoxify naturally. . .
. . . Xanax can cause severe drowsiness and difficulty breathing, which may be life- threatening. . . .
. . . Xanax can be dangerous for people with lung problems or breathing problems. Be sure to discuss any breathing or lung problems with your healthcare provider before taking Xanax. . . . -
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Keebler
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- IV GLUTATHIONE has been known to pull some out of severe herxheimer reactions. Many LLMDs are familiar with this. Likely more accessible through a LL ND.
IV MAGNESIUM, with Taurine and other nutrients can also be helpful to turn a corner.
[ 06-16-2013, 04:19 PM: Message edited by: Keebler ]
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- This is in the "How the Liver Works" articles, etc. but some may not actually read all the articles above.
A part of liver support that is not talked about much: poo.
Be sure to eat LOTS of good veggies and that your colon moves once or more times a day. Getting good food into us, & moving through, is a huge help to the liver.
We take the nutrients into our cells for better organ functioning - and the spent food moves the toxic waste out for us.
Not enough emphasis is put on how much food we can move through - and out of our GI tract. So often, it's not enough. Nine servings of veggies a day is a good goal. -
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- INFRARED, or LOW HEAT SAUNA - don't think that has been mentioned here.
WARM (never hot) baths, too. -
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- Julie (lymeinhell) just posted this at another thread. It looks like an excellent, well balanced liver / kidney support.
[Although generally be careful about any "detox" product as some can be too harsh. This one looks like they've taken the right approach, though and it's food for the body so it can do its job better.]
In 1993, at the age of 22, Jenna Henderson was struck with the rare kidney disease, focal segmental glomerulosclerosis (FSGS). . . .
. . . But she graduated president of her class in medical school and wrote a doctoral thesis about the safety of herbal medicine with transplanted organs. . . .
Mentions that "23andMe tests for mutations of the CYP450 enzymes." (end quote)
[my voice here] and that is much easier than the typical porphyria tests described in posts above. While all dysfunctions of the CYP450 liver pathway may not be a "true" porphyria, it certainly can be and it's not always such a black & white "condition" as some might like to think.
The liver is oh, so very important, and this author has given us a real gift with this article.
And, oh, about that ever so important glutathione the author discusses, remember that there are many OTC products and even some drugs that block glutathione not just in our liver but in the individual cells throughout the entire body.
And that is never a good thing. We can try to raise glutathione levels till the cows come home but if we are taking something that blocks that - the cows will come home before we can get glutathione where it should be. -
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There are many discussion threads for 23andMe here at LymeNet. While they no longer interpret raw health data, there are others that can help in that regard.
Search in the LymeNet Archives for threads relating:
23andMe
MTHFR
Methylation -
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- In addition to some links posted early about enzymes, here's another good article.
Because inflammation is such a major contributor to pain and to gallbladder & liver & kidney dysfunction . . . WOBENZYME or other ENZYME formulas may be very helpful, too.
Many LLMDs and LL NDs such enzyme support. Why, you ask? Excellent, thorough information all the way to the end:
Understanding Proteolytic Enzymes -
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- lpkayak just posted this very important question about c. diff -- which can be a nasty low gut infection. Antibiotics without specific probiotic support &/or with PPI classification of Rx can set someone up for this. Steps to take:
C difficile - how to prevent? -
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- The liver risk of acetaminophen is discussed in an early post above, as it the kidney risk of ibuprofen.
HEART & STROKE Risk is now in today's news regarding some non-aspirin NSAIDS. The link was far too wide, so you can search here - or find the detail elsewhere with a few key search terms.
While the article "includes" a few by name, probably best to check official sites / lists if you have any question about something you are taking.
Both OTC & Prescription categories included in this report / new warning.
- By Sabrina Tavernise- The New York Times - July 9, 2015
Excerpts:
WASHINGTON — The Food and Drug Administration is strengthening warnings on painkillers like ibuprofen to say that they cause an increased risk of heart attack and stroke.
The over-the-counter forms include Advil, Motrin IB and Aleve.
The distinction was subtle: The labels already say such drugs “may cause” increased risk of heart attack and stroke.
But the agency said that new data from a recent analysis provided stronger evidence of the increased risk of heart failure from such drugs, called nonaspirin nonsteroidal anti-inflammatory drugs (Nsaids), which are taken by millions of Americans. . . .
. . . In the coming months, the agency said it would ask manufacturers to change the labels to say that the drugs “cause an increased risk” of serious heart failure.
It also will ask them to add that the risk may occur early in treatment and may increase the longer the patient uses the medicine.
. . . The agency first warned of the risk of heart attack and stroke in the prescription medicines in 2005. . . . -
[ 07-09-2015, 11:28 PM: Message edited by: Keebler ]
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With so many healthy diet theories flying around these days, it can be hard to know what is actually good for our bodies.
Here's a completely different view of food, one that's been established for thousands of years.
By Hang-Shuen Lee - for Deutsche Welle News - 24.08.2015
[Concept article that explains the reasoning behind culinary practices exceedingly well; stunning photos. There is absolutely no way this will not entice and encourage us to all create delicious foods for our body & spirit. Ahhhh.] -
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- I really thought I had posted this already here but my eyes cannot find it now. And too tired to explain the connections but there are many. Basically, lyme - and treatment - can mess with vestibular function. Detail to consider so treatment can work the best:
Topic: TINNITUS: Ringing Between The Ears; Vestibular, Balance, Hearing with compiled links - including HYPERACUSIS -
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After getting assessed for h. pylori as a possible cause, & considering diet . . .
Some safer choices to help calm heartburn: Ginger; Slippery Elm Bark; Marshmallow root; Licorice (DGL). All can be searched in this book / site, too. For a good start:
GINGER - Chapter from The One Earth Herbal Sourcebook -
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- TIMING, SPACING are discussed throughout this thread regarding the right balance with support methods and not having a drug either get cleared too quickly from the body or build up. Beyond that, to the basic interaction search.
I really thought this had been included here but now my eyes cannot find it. So, here you go, a great article / chart to keep on hand, print out and put with your books:
- From one of the most well respected herbal researchers in the world at ITM:
Institute for Traditional Medicine, Portland, Oregon
This article will also help guide methods for cross searching drugs that are new to the market. -
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Keebler
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Guidelines for THE SAFE USE OF HERBS -
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Keebler
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posted
- Many Rx can be hard on the liver / kidneys, etc. Still, some can have all kinds of reactions when mixed with other Rx.
[Earlier in this thread are some links about herb / Rx interactions and timing detail to be aware of as well.] Just saw this and thought it would be helpful to this thread:
TED*MED Nov. 2015: What Really Happens When You Mix Medications?
Russ Altman - 14:45 Video . . . and transcript
If you take two different medications for two different reasons, here's a sobering thought:
your doctor may not fully understand what happens when they're combined, because drug interactions are incredibly hard to study.
In this fascinating and accessible talk, Russ Altman shows how doctors are studying unexpected drug interactions using a surprising resource: search engine queries. -
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Keebler
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Commonly used heartburn drugs may lead to kidney damage: study
By Ashley Welch CBS News April 14, 2016
Long-term use of a common type of medication used to treat heartburn, acid reflux, and ulcers may lead to an increased risk of kidney disease and kidney failure, new research shows.
The study, published in the Journal of the American Society of Nephrology, adds to prior research that suggests proton-pump inhibitors (PPIs), a group of drugs which reduces gastric acid production, can lead to serious kidney damage. . . . -
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Keebler
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. . . acid blockers don’t merely shut off acid pumps in the stomach? Recent research warns that they also shut off production of acid inside the mitochondria every cell in our bodies! . . .
. . . The health of our mitochondria determine our overall health. Yet here we are blithely interfering with their cellular energy production and detoxification processes.
Sometimes our cells need more acid and sometimes the opposite. But you can be sure that no drug company knows (or cares) precisely what your mitochondria need to keep your cells happy and flourishing.
Each cell may have hundreds or even thousands of mitochondria. . . .
. . . Kidney disease is only one among many known health problems caused by acid blockers, including higher risks for
[Full article at link above.] -
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Keebler
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posted
- MITOCHONDRIA considerations.
This could go in various places but decided to park it here as our mitochondria are vital to take in nutrients and then being able to move metabolic waste out of our cells.
If we take certain Rx that block or mess with mitochondria, that can also block attempts to help the kidneys or liver in their jobs of waste removal.
I'm looking at this article in a different way than authors likely intend. I'm looking at it so as to know how Rx can mess with us. Many Rx interfere with mitochondria and, even if it's intent is supposed to be "good" the effect can be bad for us in various ways.
Mostly to get an idea of how some Rx affect mitochondria. Also keep in mind that lyme, TBD and other chronic stealth infections can do their own tricks with mitochondria and we have to be proactive.
By Adam Szewczyk and Lech Wojtczak [Warsaw, Poland]
Abstract
Mitochondria play a central role in energy metabolism within the cell. Mitochondrial dysfunctions lead to various neurodegenerative disorders and to the so-called “mitochondrial diseases”.
A vast amount of evidence points to the implication of mitochondria in such complex processes as apoptosis and cardioprotection.
The purpose of this review is to present a recent state of our knowledge and understanding of the action of various therapeutically applied substances on mitochondria.
These include antitumor, immunosuppressant, and antiviral drugs, potassium channel openers, sulfonylureas, and anesthetics. Some of these substances are specifically designed to affect mitochondrial functions.
In other cases, drugs with primary targets in other cellular locations may modify mitochondrial functions as side effects.
In any case, identification of mitochondria as primary or secondary targets of a drug may help us to better understand the drug's mechanism of action and open new perspectives for its application.
As far as possible, the molecular mechanisms of the interference of particular drugs in the mitochondrial metabolism will be described. In some cases, metabolic routes in which the drugs interfere will also be briefly outlined.
[Very helpful outline - this is truly amazing to see & full article at link above]
Septic Shock - Links; Discussion regarding the extreme & emergency Cytokine Storm issues not related to lyme yet important to know as basic detail for life. -
[ 09-24-2016, 04:04 PM: Message edited by: Keebler ]
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ACS Nano. 2015 Aug 25;9(8):7775-82. doi: 10.1021/acsnano.5b01696. Epub 2015 Jun 25.
Nanoparticle-Stabilized Capsules for the Treatment of Bacterial Biofilms.
Excerpt:
. . . The peppermint oil and cinnamaldehyde combination that comprises the core of the capsules act as potent antimicrobial agents. . . . -
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Keebler
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posted
- BINDERS
Thanks to TF for pointing this out in another thread. An excellent post here:
Daily exposure to ultra-low levels of glyphosate for two years led to non-alcoholic fatty liver disease (NAFLD) in rats
The study involved glyphosate exposures of 4 nanograms per kilogram of body weight per day, which is 75,000 and 437,500 times below EU and U.S. permitted levels, respectively
Past research has suggested the liver disease non-alcoholic steatohepatosis (NASH) may be primarily due to glyphosate disrupting gut metabolism of fructose
Excerpts:
If you started your day with a bowl of oatmeal, Cheerios or even organic cage-free eggs, there's a good chance you consumed a small amount of glyphosate residue along with it.
Likewise, if you've recently snacked on popular brands of crackers, tortilla chips and pita chips, or consumed beer or wine.1
As the results of increasing numbers of independent tests come in, it's becoming increasingly clear that glyphosate, the active ingredient in Monsanto's Roundup herbicide, is showing up virtually everywhere — in our food, water and even in baby food and women's breastmilk.
It's not altogether surprising — glyphosate is the most heavily-used agricultural chemical in history — but it is incredibly concerning. The health risks of glyphosate, though downplayed by the chemical's makers, are accumulating daily.
Roundup Causes Liver Disease at 'Ultra-Low' Doses . . .
[Full article at link above]
[-] Sources and References
Scientific Reports January 9, 2017 Scientific Reports December 19, 2016 PLOS One December 30, 2016
Sustainable Pulse January 9, 2016 GM Watch January 9, 2017 The New York Times January 9, 2017
The Huffington Post January 6, 2017 1 EcoWatch November 14, 2016 2, 5 Scientific Reports January 9, 2017
3, 4 Sustainable Pulse January 9, 2016 6 American Cancer Society, Liver Cancer
7 Journal of Applied Toxicology November 19, 2011 DOI 10.1002/jat.2712 (PDF)
8, 9, 10 Scientific Reports December 19, 2016 11, 12 The New York Times January 9, 2017 13 PLOS One December 30, 2016
14 EcoWatch 15 The Huffington Post January 6, 2017 -
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Liver support properties of Triphala unlike many others. More gentle yet also can effectively permeate various levels of body tissues. You'll have to read through all the articles entirely to get the full picture and still, this is just the tip of literature on it. Time well spent. -
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The underrated, unloved liver performs more than 300 vital functions. No wonder the ancients believed it to be the home of the human soul.
By Natalie Angier - The New York Times - June 12, 2017 -
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Keebler
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posted
- Lots about liver support is about reducing inflammation with antioxidants. As minerals are also mentioned in the notes below, note that something often suggested to help the liver is Chlorella &/or Spirulina. Both contain wonderful nutrients.
TF's recent post in another thread shines a light on some key factors. The thread in which she supplied this reply was asking:
"How to get rid of Brain Fog?"
TF: According to Dr. H., #1 lyme doc in the U.S., the key to getting rid of brain fog is to get rid of inflammation. Lyme causes lots of inflammation, including in the brain. This results in low blood flow to the brain. Hence, the brain fog.
See these notes I took from a recent talk of Dr. H:
1:18 You must check the red blood cells for low minerals (magnesium, copper, zinc) or the inflammation will continue. [My note: in other words, a regular blood test will not discover these. You need the red blood cell test instead.]
1:19:30 He gave 2 grams of glutathione daily to get rid of brain fog in a computer programmer and after that, the patient could work again. So, just detoxing him enabled him to get back to work.
1:22 Low Vitamin D is associated with MS (the patient will have the wrong ratio of 125 to 25 Vitamin D) This indicates inflammation.
1:24:21 The more viruses (CMV, HSV-1) and bacteria (including Bb, c. pneumonia, H. pylori) in your brain, the greater your chances of getting Alzheimer’s. If you can shut down the inflammatory process, the symptoms will get better.
1:26 To lower inflammation: Use plaquenil, IVIG, antioxidants, CoQ10, glutathione precursors, B vitamins, ALA, omega 3s, glutathione. He uses green tea extract, curcumin, resveratrol and broccoli seed extract. The broccoli seed extract also hits cancer genes. He likes it. Cancer runs in his family, so he takes it.
1:26:40 LDN 1:27 Eat an anti-inflammatory diet (use either Paleo or Mediterranean), replace your minerals, treat all infections, detox, avoid foods you are allergic to, and get your sleep as additional ways to lower inflammation.
Here is the post so you can see the video for yourself:
Believe me, getting the inflammation down is key in lyme and lyme treatment. It takes a real expert to help the patient get it down as much as possible.
If the patient cannot detoxify well (1/4 can't), then lots of detox is necessary. Glutathione (over the counter, but prescription is better) is one of many things to help the person detoxify.
Do as many of the anti-inflammatory things as you can.
The numbers in my notes tell you the minute and second at which the subject is addressed on the video.
[End post by TF] -
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contains the amino acid N-acetyl-L-cysteine, a key component of glutathione—a tripeptide that plays a significant role in detoxification and antioxidant support.
Liver Protect also contains a combination of alpha-lipoic acid, silymarin from milk thistle, and selenium for support of antioxidant activity, regeneration of other antioxidants, and promotion of healthy immune function.* -
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