posted
Need help with explanation of CD-57 test. We didn't have it done through LabCorp though (long story). It's called a leukemia/lymphoma phenotype test.
Interpretation: No increase in blasts; polytypic B-cells. T-cell panel: Flow cytometric immunophenotyping was performed with antibodies directed against the following antigens; CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD16, CD45, gamma/delta T-cell receptor heterodimer, and kappa and lamda immunoglobulin light chains.
Panel Interpretation: There is a mixture of CD4 and CD8 positive T-cells with unremarkable expression of T-cell-associated antigens CD2, CD3, CD5, and CD7. CD3-negative, CD16-positive natural killer (NK)-cells are not increased; they show unremarkable expression of CD2 and CD7. Immunophenotyping was performed on the peripheral blood specimen with antibodies directed against the following: CD3, CD16, CD56, CD57, CD94, CD161, and the killing inhibitory receptors (KIR antigens) CD158a, and CD158b, and CD158e. The CD16 positive and CD3 negative NK-cells expressed CD56 (dim), CD57, CD94 (dim), and CD161 (dim). These cells showed polytypic expression of the KIR antigens CD158a and CD158b. This pattern of KIR expression is most consistent with expansion of a subset of reactive NK-cells. Posts: 252 | From Iowa | Registered: Mar 2006
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bettyg
Unregistered
posted
quote:Originally posted by mikej2323:
Need help with explanation of CD-57 test. We didn't have it done through LabCorp though (long story).
It's called a leukemia/lymphoma phenotype test. Interpretation:
No increase in blasts; polytypic B-cells. T-cell panel: Flow cytometric immunophenotyping was performed with antibodies directed against the following antigens;
CD2, CD3, CD4, CD5, CD7, CD8, CD10, CD16, CD45, gamma/delta T-cell receptor heterodimer, and kappa and lamda immunoglobulin light chains.
Panel Interpretation:
There is a mixture of CD4 and CD8 positive T-cells with unremarkable expression of T-cell-associated antigens
CD2, CD3, CD5, and CD7. CD3-negative, CD16-positive natural killer (NK)-cells are not increased; they show unremarkable expression of CD2 and CD7.
Immunophenotyping was performed on the peripheral blood specimen with antibodies directed against the following:
CD3, CD16, CD56, CD57, CD94, CD161, and the killing inhibitory receptors (KIR antigens) CD158a, and CD158b, and CD158e.
The CD16 positive and CD3 negative NK-cells expressed CD56 (dim), CD57, CD94 (dim), and CD161 (dim).
These cells showed polytypic expression of the KIR antigens CD158a and CD158b. This pattern of KIR expression is most consistent with expansion of a subset of reactive NK-cells.
Mike, I'm confused too big time! I posted recently in my 4-20-06 new LLMD summary and lab sresults. I typed up everything sent to me, but nothing rings a bell like above. Sorry.
What did the MDs say who took this?
Also, try NIH's www.medlineplus.org and type in the name of the test, plus leukemia name, etc! good luck!
Up for nurses & others in medical field.
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david1097
Frequent Contributor (1K+ posts)
Member # 3662
posted
A bit technical but I will give it a try...
First, CD57 studies as they relate to lyme are given as CELL COUNTS per volume of blood. The test that you had does not do this (or at least is not reported this way), instead it measures for abnormal presence of a wide range of NK cell types. They may have a count number somewhere but it is not on the report. I suppose that one can assume (or maybe not) that if one of the cell types tested for was not present or had an abnormally high/low number, they would have reported it. Abnormally low CD57 counts has been associated with Lyme infection.
The test results appear to be normal, with the only thing being commented on is the cd158a & b being present, which could be indicative of some sort of abnormality but lilely is not. The KIR cells can be abnormally high in a number of things ranging from endometriosis to lukemia to other cancers, however these diseases are THOUGHT to also show other patterns with the other cells that they measaured. The best I can figure, the test did not show a pattern and as a result the test, despite the 158a and b is basically normal.
DO NOT TRUST ME ON THIS AS I KNOW VERY LITTLE ABOUT IT. ASK YOU DR. HOPEFULLY HE WILL KNOW OR CAN FIND OUT.
As a quick background KIR cells are cells that LIMIT the response of the immuue system cells, basically KIR is used to "turn down" the immune system response to certain things. It is though to be used by various infections and tumours so as to allow the infection/tumor to growth unchecked.
Hope that is of some use.
Posts: 1184 | From north america | Registered: Feb 2003
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