AliG
Frequent Contributor (1K+ posts)
Member # 9734
posted
Thanks TC-
I'll have to try reading this again later. I think I may be experiencing a disruption of THOUGHT control. Think it could be related?
-------------------- Note: I'm NOT a medical professional. The information I share is from my own personal research and experience. Please do not construe anything I share as medical advice, which should only be obtained from a licensed medical practitioner. Posts: 4881 | From Middlesex County, NJ | Registered: Jul 2006
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posted
Tincup thanks - I too need to read this later. Having trouble processing info.
When I was being treated for MS, i was on Copaxone. My interpretation of the way this med works - very simply - is that it protects the myelin. I think it did protect this from the lyme that I unknowingly had.
I wonder if it will ever be used for us neuro lyme patients.
-------------------- This is NOT medical advice - and should NOT be used to replace your MD's advice. Info is only the opinion of those who publish the site.
The shortest way to do many things is to do only one thing at a time.
cb Posts: 669 | From somewherebetweentherocks | Registered: Mar 2008
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Tincup
Honored Contributor (10K+ posts)
Member # 5829
posted
Some days.. many days actually... I can't read this stuff either.
Here is the 2nd grade explanation.. which I often need drawn out for me if I am to "get it".
Picture this....
On the table you have a marble. Next to it you place a "pat" of butter. Next to the butter is another marble.
Make a long line using marble, butter, marble, butter.
Now... pretend you are an ant.
Your goal is to run as fast as possible across the top of the marble/butter line.
Duu duu duu duu duu duu duu doooo...
The starting pistol goes off and you haul across... slipping and sliding on the marbles and butter... right to the end!
14.2 seconds... a world record!!!! Yea!!!!
The next day you decide to try it again to see if you can beat your own record.
You get ready, set, go!!!!
But...
The butter has since melted in the 90 degree Florida sun!
OH NO Mr. Bill!
You hit that first marble at a full charge.. but you spin around and topple off because the butter isn't there to help guide you and help you slide though the line this time.
You pick yourself up and keep going.. and again... you fall sideways off the marble.
It takes you 23.52 minutes to do what you did the day before in 14 seconds!!!! NOT GOOD!!!
The marbles are your nerves. The butter is your myelin sheath.
You are good to go with the correct line up of marble, butter, marble, butter.
BUT... when the butter was no longer there to make the run smooth.... you, the ant ... stumbled ... and it took a lot longer to get to the other side.
The ant represents the signals heading to various muscles, tissues, organs, etc... to tell them what to do.
With Lyme disease, your butter is compromised or even destroyed... also like in MS patients.
When that happens... your signals go slip sliding around and do not make it to where they are headed easily... or quickly.
posted
Geneal, thanks for this info. My oldest is now
18, however she did have speech delays and was
speech therapy for a few years.
I am pretty sure that she was born with lyme.
Not that this info is going to change anything
now, just another piece to the big picture that I
never thought of before.
-------------------- This is NOT medical advice - and should NOT be used to replace your MD's advice. Info is only the opinion of those who publish the site.
The shortest way to do many things is to do only one thing at a time.
cb Posts: 669 | From somewherebetweentherocks | Registered: Mar 2008
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
The myelin sheath is made from CHOLESTEROL.
Giving mice the hormone, Prolactin, spontaneously restored the myelin sheath (very recent research).
Prolactin levels often go UP in lyme...IMO...protective measure.
Bb's outer cell walls need the amino acids that make up cholesterol and it follows the "cholesterol pathway"...as does cholera.
It looks to be using OUR amino acids (certain ones) to build OspA, B, etc. - outer surface protein A, B, etc.
To eliminate a pathogen, we need to breakdown the cell walls OR inhibit their formation in the first place. That is how our own system AND antibiotics work. They impact the proteins in the outer cell walls. T cells lock onto these proteins and begin the destruction.
Osmotic pressure changes then kicks in to finish the job (once cell wall deficient).
Unfortunately, in hostile conditions, within 20 minutes Bb can "shape-change" and as we all know the cyst form is very difficult to penetrate.
Since we are all fighting multiple pathogens simultaneously ongoing...it is likely some infected with Bb could also be co-infected with whatever pathogen triggers MS symptoms.
Incidentally...70% of us carry H. Pylori (stomach ulcer) and it normally doesn't cause problems. That pathogen locks onto lactoferrin and fibrinogen.
H. Pylori is linked to asthma, glaucoma, uveitis, ocular rosacea, stomach cancer, etc.
UVB (blue wavelength) helps as does mastic gum...if H. Pylori is present.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
Does this lead to neuropathy which I experience?
Posts: 2905 | From New England | Registered: Sep 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
More likely too much glutamate.
"Glutamate is the ``primary excitatory neurotransmitter in the human nervous system'' (Reviewed in Zhou et al., 2005), participating in a multitude of brain functions.
Over stimulation and activation of glutamate receptors as well as ``disturbances in the cellular mechanisms that protect against the adverse consequences of physiological glutamate receptor activation'' (Kowzikowski et al., 2001) have been known to cause neuron damage and death which has been associated with multiple neurological diseases (Reviewed in Zhou et al., 2005).
Due to the pure range of glutamate function and presence, it has been difficult to create glutamatergic drugs that do not negatively affect other necessary functions and cause unwanted side effects (Nagel et al., 2006)"
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
I had been taking L-glutamine the other day in order to stimulate my immune system and to help repair a supposed leaky gut, as well as heal the sinuses.
I started to get headaches and my sensitiviites got worse.
I read somewhere that Glutamine converts in the Glutate in the body when the amounts are there.
So how do we take this then if its only going to convert to glutmate?
Posts: 2905 | From New England | Registered: Sep 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
N-Methyl-d-aspartate (NMDA) and l-glutamate activate membrane receptor that produce substantial
*permeation of Na+, K+ and Ca2+ through the neuronal membrane*.
Making Bb a happy camper.
See my post today on PDE and cGMP...plow your way thru it and try to understand.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
Oh my God Marnie. Why cant the piracetam work like it used to so I can understand your language.
Posts: 2905 | From New England | Registered: Sep 2004
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
-------------------- Bob Posts: 2150 | From Maryland | Registered: Dec 2007
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lymeHerx001
Frequent Contributor (1K+ posts)
Member # 6215
posted
If I have no white spots in my MRI yet my feet still burn does this mean that the nueropathy is not coming from destruction of the myelin?
Posts: 2905 | From New England | Registered: Sep 2004
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