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» LymeNet Flash » Questions and Discussion » Medical Questions » Can you become resistant to Doxy after repeated use?

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Author Topic: Can you become resistant to Doxy after repeated use?
lymebytes
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Doxy has worked well for my son when he relapsed.

Currently he is on Mino - but showing ototoxic side effects.

Can Doxy work as well after using before...or do you become resistant to it?

I have heard Doxy and Mino are identical - only difference Doxy is safer.

Mino has worked well in the last month but it is time to go off w/signs of ear problems.

My son doubts Doxy can keep working ...I want your opinions...I say it can..what are your experiences.

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www.truthaboutlymedisease.com

Posts: 2003 | From endemic area | Registered: May 2007  |  IP: Logged | Report this post to a Moderator
chamade
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As far as I know borrelia doesn't become resistant to any abx, so it should work.
I recently switched from doxy to mino after 1 year on doxy. I have herxed like crazy and am doing better now. Mino is twice as lipo soluble as doxy and it penetrates the CNS much better.

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Why me? Well, why not me???

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psano2
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In general, resistance is a matter of a genetic selection process. i.e., the bugs that are susceptible to an antibiotic are killed off and those that have a gene that confers them resistance to the drug survive and multiply.

So in this way, resistant strains can be selected out, possibly creating so called "superbugs", making an infection harder to treat. This is the basis for mainstream medicine's (such as IDSA) argument against long term antibiotic therapy.

This is the basis of the fear of getting a MRSA, or methicillin resistant Staphylococcus aureus.
Methicillin is one of the last lines of antibiotics that will kill Staph, so if that doesn't work, then the patient is basically screwed, at least in the view of most in modern medicine.

Personally, I believe that there may be herbs that will work against MRSA, but we all know that mainstream medicine has still not opened up to herbal therapy.

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Geneal
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I think doxy is a second generation and mino a third. Of course I could be wrong. [dizzy]

I couldn't do mino. It is supposed to cross the brain blood barrier better than doxy.

I have done well on doxy, but not during the summer. Yikes! [Eek!]

In the last 20 months I have been on doxy off and on depending on current treatment

And time of year at least 5 times. I herx every time.

Hugs,

Geneal

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ByronSBell 2007
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The borrelia itself will not become resistant to the doxy.

BUT!

The borrelia forms a coat to protect itself, so heparin and fibrogen reducing meds need to be used so the antibiotics can reach the bacteria.

Borrelia also changes forms and those other forms need to be treated with different antibiotics.

Your son could also have co-infections that could be making him relapse, just to slip you a hint... Out of 28 current patients at the lyme clinic I am at, all 28 patients have atleast 1 co-infection alot of them several, like myself.

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lymebytes
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Thanks for replies!

Yes he is co-infected. Relapse has occurred everytime he returns to the gym! He gets exposed to something, starts off as flu or cold and bam...lyme comes rushing back.

He has done some heavy hitters this time including Flagyl..mino I read does penetrate better...BUT they say Doxy does at twice the dose. So in other words, Mino 200 mg is equiv to 400mg of Doxy is the way I understand it.

Interesting article: http://www.journals.uchicago.edu/doi/full/10.1086/313604?cookieSet=1 (if it doesn't appear click on pdf or I believe full text -at the top)

Thanks for your great advice and experiences..much appreciated!

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www.truthaboutlymedisease.com

Posts: 2003 | From endemic area | Registered: May 2007  |  IP: Logged | Report this post to a Moderator
   

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