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» LymeNet Flash » Questions and Discussion » Medical Questions » Pregnenolone & DHEA after Adrenal Stress Test?

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Author Topic: Pregnenolone & DHEA after Adrenal Stress Test?
LymeNet Contributor
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Hi All,

I had an Adrenal Stress Index test done and I'm not sure how much stock to put into it due to can't it change all the time?

Depending on so many variables, couldn't I have one everyday and each day would be different?

The results that were not "normal" were:

TAP 10:00 - Midnight 5 elevated

ISN non-fasting under 3 depressed

P17-OH 17-OH Progesterone under 15 Depressed

MB2S Total Salivary SIgA 10 Depressed

My LLMD has given me DHEA 10mg to take one cap a day and Pregnenolone 30 mg to take one cap a day, which I didn't really worry too much about until I started reading a little bit about them.

Since they are both hormones and the thought of taking hormones have always made me a bit skittish, I'm wondering if anyone has taken them?

If so, have you had good results? Bad results? Anything I should be aware of or look out for?

They are to, hopefully, help combat a little bit of depression/emotional sensitivities and fatigue.

I also just got some bloodwork back showing my Glucose, Serum at 112, which compared to last test on 2/19 that was 87.

My LLMD had me go take another one and to do it while fasting, which I did the other day and am waiting for the results.

And, wouldn't the results of a depressed insulin contradict the high glucose? I don't know much about this stuff (as you can tell!; )) so I'll have to read more, but thought I'd get some quick answers here.

Posts: 217 | From Earth | Registered: Feb 2010  |  IP: Logged | Report this post to a Moderator
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Sick since January 1985. Misdiagnosed for 20 years. Tested CDC positive October 2005. Treating since April 2006.

Posts: 3228 | From Somewhere west of the Mississippi | Registered: Aug 2007  |  IP: Logged | Report this post to a Moderator
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I also have started taking DHEA for my adrenal and have wondered about it. I've been taking the DHEA with Pregnenolone for a week now.

I'm sleeping better and less night sweats with it. Also on Amour and Ioderal for my hypothyroid from my LLMD.

Anyone take this long term or have any side effects with lyme treatment?

Lyme, Babs, Fry Bug..... Whatever it is, may a treatment be discovered to make us all whole again!

Posts: 934 | From AZ-MT | Registered: Oct 2004  |  IP: Logged | Report this post to a Moderator
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my old doctor put me on pregnenolone cream a while back. i only lasted a week on it. it made me feel REALLY WEIRD and anxious.

i'm sure it works great for some people but do listen to your body. i did not have a good experience with that stuff!

Symptoms since age 4
IGM positive Western Blot (Bb)
PCR positive Spiro Stat (Anaplasma)
Suspect babs and bart

Posts: 226 | From Currently in Los Angeles, originally from Malvern, PA. | Registered: Feb 2010  |  IP: Logged | Report this post to a Moderator
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After my ASI test, I was put on DHEA at 15 mgs., but it made me shaky after awhile. I was put on it by a doctor, but noticed no benefit, so I stopped after about 3 months.

I have been on pregnenolone for several years. Without it, my Lyme rages are ten times more prevalent and severe.

I take a tiny dose though, only 15 mgs. 3 times a week. If I take more, I get migraines, just like before menopause, and the only good thing about menopause was having no more migraines.

When I took 30 mgs. a day, I became so much nicer again, felt like being social and had no rages. I sure wish I could take that much.

But, the migraines sent me to the ER, since I can't handle pain pills with my other drugs....they make me stop breathing. They had to give me a knock out drug to prevent a stroke!

I noticed a huge change in my personality at menopause, and I think pregnenolone helps me because I need the "nice" hormone "estrogen" to keep from over-reacting to stressers and flying off the handle. I had no temper before menopause.

I was tested before starting Pregnenolone and my estrogen was 19. After 2 months on 30 mgs. daily, it was 110, which is a premenopausal number, and it brought back my migraines. I would advise taking it up slowly, since we are so sensitive to drugs,etc.

I also was put on SAMe to fix my low SIga, but it did nothing after two months and was quite costly, so I stopped it.

I have found the one thing that improves my ASI scores is several months in a row with no major stress in my life, but that hardly ever happens. It happened once though, and my morning cortisol went up to 18.8, proving what a strong effect stress has on lowering it, since I dropped to 8 after something bad happened.

Good luck with it. I hope you are monitoring the strength of your pupil dilation in the dark, and the difference between your supine and standing blood pressure to keep track of what kind of results you are getting.


Posts: 1266 | From Clearwater, Florida, USA | Registered: May 2004  |  IP: Logged | Report this post to a Moderator
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Thanks for the comments.

Klutzo - I too was taking Sam-e for a few months. It seemed to be helping a little bit at first, then the longer I took it, the more it seemed to do nothing, so I stopped as well.

My LLMD also put me on NeuroReplete and I'm hoping that will help.

Posts: 217 | From Earth | Registered: Feb 2010  |  IP: Logged | Report this post to a Moderator

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