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Posted by Ann-Ohio (Member # 44364) on :
 
A Review of Antibiotic-Tolerant Persisters and Their Relevance to Post-Treatment Lyme Disease Symptoms
Baker PJ.
The American Journal of Medicine, online first 2020 Jan 9.

https://doi.org/10.1016/j.amjmed.2019.12.007


Abstract

Several well-controlled clinical trials have shown that prolonged antibiotic therapy has no benefit in relieving post-treatment Lyme disease symptoms.

However, some insist that such symptoms are due to a persistent Borrelia burgdorferi infection requiring prolonged antibiotic therapy to resolve.

This unproven view is bolstered by the results of in vitro where small numbers of viable B. burgdorferi can be detected after treatment with antibiotic.

The results described in the present work suggest that the presence of persisters can best be explained by classic biochemical kinetics

and that there are alternative explanations for this phenomenon that appears to have no clinical significance.
 
Posted by Ann-Ohio (Member # 44364) on :
 
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