posted 30 May 2004 13:12
(1) The genetic analysis of Bb indicates it has a 60 kDa pyrophosphate dependent PFK (phosphofructokinase) enzyme.PMID: 12015149 (www.pubmed.com)
(2) The enzyme, PFK, is “rate limiting” for glycolysis (using glycogen, not oxygen, to supply energy). And we know Bb is anaerobic – does not need oxygen. It wants/needs sugar.
PMID: 10689623 (www.pubmed.com)
PMID: 1832860 (www.pubmed.com)
(3) PFK is INhibited by Mg-ATP (et al). (Most ATP is bound to Mg.). Insulin ACTIVATES it.
http://www.geocities.com/doctor_uae/carbohydrates.htm
http://www.mcw.edu/student/mcwsa/files/biochem22.doc
http://www.eimb.relarn.ru/eimb/3nature.htm
www.apjohncancerinstitute.org/newsletter-old2.htm
http://www.lowcarbluxury.com/newsletter/lclnewsvol03-no04-pg2.html
(4) Bb follows the cholesterol/ mevalonate / isoprenoid pathway. It has another enzyme: acetyl-CoA C-acetyltransferase. Cholesterol is needed to form the myelin sheath, the insulation around our nerves. In MS, this sheath is damaged.
(Rohmer 1999; Kim et al. 2000; Wilding et al. 2000a, b). or
http://proteinscience.org/cgi/content/full/13/3/687
http://www.sbc.su.se/~anna/PhylProM/families_with_members_in_profile/gi1652965.html
http://web.indstate.edu/thcme/mwking/cholesterol.html
http://adams.mgh.harvard.edu/Reeves/workingresearch2.htm
(5) Mg (and statin drugs) INactivate the enzyme 5-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) which then reduces mevalonate, the first step in the cholesterol pathway.
http://www.lef.org/whatshot/2004_11.htm
Neurol India 2003;51:211-214
The above suggests that intracellular Mg levels play a critical role in regaining control of the glycolysis and cholesterol pathways which are impacted by this pathogen.
(6) Cancer doctors at a Romanian hospital found a very “significant” drop in Mg levels early on in 2 lyme patients. By restoring their magnesium levels, they were cured of lyme disease. Please note: this was caught early.
http://coldcure.com/html/2003-mag-abstracts.pfd
(Takes 2 minutes to download. Scroll down to page 68.)
It is “noted” here:
PMID: 14979639.
And here:
http://www.ad-astra.ro/isi/topic_articles.php?topic_id=IA
Sometimes, but not always, the coldcure website is hard to get into. So, I will post the abstract in its entirety here:
Lyme disease and magnesium deficiency
V. CRISTEA - Department of Immunopathology, Medical Clinic III, "Iuliu Hatieganu"
University of Medicine and Pharmacy, MONICA CRIAN - Department of Immunology,
"Ion Chiricu" Oncological Institute, Cluj-Napoca, Romania
V. CRIAN - ITEM-Paneuro Group. vlaicu@.m@if..c;!ntci,rQ
During the period April 2001 - January 2003, we had under observation two cases, in
which the presence of both IgM and IgG antibodies to Borrelia burgdorferi was
serologically confirmed at high titers.
In both cases, clinical manifestations were
similar: shivering, fever, headache, articular and right hypochondrium pain, and
objectively - tachycardia and erythema migrans - these elements being important for
the formulation of Lyme disease suspicion.
Humoral tests showed: significantly
increased ESR, leukocytosis with PMN predominance, intensely positive PCR (for B.
Burgdorferi DNA)
and significant magnesium deficiency (1.20 mEq/L, 1.33 mEq/L,
respectively).
A large spectrum of antibiotics with both oral and parenteral
administration has been so far used in the treatment of Lyme borreliosis. Among the
most frequently used are tetracyclines, betalactamides and cephalosporins.
The decision to initiate antibiotic therapy can be difficu1t because in the majority of the
cases acute infection is self-limited.
Asymptomatic patients, in whom laboratory
examinations sustain the diagnosis of Lyme disease, should be treated in order to
prevent rnfection dissemination.
Since in the first case antibiotic therapy alone did not
lead to the expected results, magnesium derivatives were also associated.
In both
cases, following combined therapy, symptomatology significantly improved at 14
days, and laboratory examinations were restored to normal values after 6-8 weeks -
disappearance of IgM to B. Burgdorferi and significantly increased magnesemia
(1.74 mEq/L, 1.72 mEq/L, respectively)
We believe that in certain diseases, Mg
deficiency can cause a decrease in immune response. The appearance of
recurrences, which are frequently reported in the literature, in spite of adequate
antibiotic therapy, could represent an argument for this.
This is why the use of Mg
derivatrves in therapy can represent an immunostimulating factor. The peculiarities of
the cases are the following:
1. Patients had in addition to fever, articular pain and erythema migrans, Mg
deficiency
2. The supplementation of therapy with Mg derrvatives had an immediate beneficial
effect that was maintained in time.
As a conclusion at this stage, we consider that in the acute phase of Lyme borreliosis
there is a significant Mg consumption and the introduction in therapy of such
preparations is recommended and beneficial.
(7) When Mg levels drop, this impacts the number and “health” of our antibodies. Since the Western Blot test measures antibodies, this may be why the testing is inaccurate (assuming it only measures healthy antibodies). The antibody specific to Bb is damaged – the “fab” portion.
PMID: 1093189 (www.pubmed.com)
PMID: 9125579 (www.pubmed.com)
(8) It takes Mg and Ca (calcium) to make completely HEALTHY antibodies.
http://www.mdschoice.com/elements/elements/major_minerals/magnesium.htm
(9) When Mg levels drop, this has a huge impact on the number of free radicals, inflammation, thymus involution, eye damage, bone loss, mitochondrial damage and so on…
PMID: 10615213 (www.pubmed.com)
PMID: 9558736 (www.pubmed.com)
PMID: 11781153 (www.pubmed.com)
http://www.mdschoice.com/elements/elements/major_minerals/magnesium.htm
PMID: 10488476 (www.pubmed.com)
J Nutr. 2004 Jan;134(1): 79-85
(10) When Mg levels drop, calcium tries to go into the cells. This triggers angiotensin II and finally TNF alpha – a proinflammatory cytokine.
PMID: 8390527 (www.pubmed.com)
(11) TNF alpha has many jobs. In fact, it is protective and beneficial.
www.Hopkins-arthritis.som.jhmi.edu/edu/acr2003/ra-treatments.html
www.dscmt.univ.trieste.it/text/curriculum/containerbiblio.htm
PMID: 10092616 (www.pubmed.com)
www.hdlighthouse.org/see/immune/tnf.htm
www.lef.org/protocols/prtcl-128a.shtml
www.diabetesincontrol.com/issue166/item1.shtml
http://www.cell-research.com/991/991-syf1.html
PMID: 9195931 (www.pubmed.com)
PMID: 12522038 (www.pubmed.com)
PMID: 14704297 (www.pubmed.com)
www.saem.org/download/01kline.pdf
Gastroenterology 2004; 126: 840-848,917-919
www.joimr.org/phorum/read.php?f=2&I=38&t=38
PMID: 8537658 (www.pubmed.com)
PMID: 15958074 (www.pubmed.com)
(12) The antibiotics may modulate the immune system response.
Antimicrob Agents Chemother. 1997 January; 41 (1): 117–121
PMID: 8331300 (www.pubmed.com)
(13) H2O2, hydrogen peroxide, is a known microbicide – capable of killing many/most pathogens. We actually make H2O2 all the time inside our cells and one of our “beneficial bacteria” in our intestine also makes this, but H2O2 is quickly broken down by an enzyme called catalase because it is not healthy for our cells to remain acidic.
Bb is H2O2 “resistant”.
http://www.news-medical.net/?id=9820
http://www.medscape.com/viewarticle/418448 (you can join medscape then access)
PMID: 11687735 (www.pubmed.com)
(14) Bb does NOT contain the enzyme catalase.
http://www2.lymenet.org/domino/abstract.nsf/0/da835aef57144e6a0525657d0005cc3e?OpenDocument
(15) In 2001, an Italian by the name of Dr. Valletta, got a U.S. patent titled: Magnesium For Autoimmune. He cured RA, ulcerative colitis and invasive cancer in 6 months using Mg pyrophosphate and sublingual B6.
To read the patent, # 6,248,368 go to our government patent website and type in the number.
(16) We are using a Mg-peroxide solution as an antibacterial agent for clothing. This is also a U.S. patent (# 5,656,037).
To read about it, once again go to our government patent website and type in the number.
(17) Co-infections complicate the healing process, especially the co-infection with the protozoan, babesia. But in the 1970s, in Germany, vets cured neuro babesia in dogs using IV sodium bicarbonate. The dogs were acidotic and responded surprisingly well to an alkaline infusion.
http://www.sodbrennen-welt.de/science/1976/1976_4617.htm
(18) IVIG has been used to successfully treat a Bb-babesia infected patient, but the abstract was removed from pubmed. It was # 13680780. This is a very expensive treatment.
Once again, please note: to make HEALTHY antibodies (immunoglobulins), we must have enough Mg and Ca.
To read this article, one can go directly to the source:
Arch Phys Med Rehabil. 2003 Sep;84(9):E34-E35.
http://www.mdschoice.com/elements/elements/major_minerals/magnesium.htm
(19) Antibiotics deplete vital nutrients and destroy beneficial bacteria which in turn make many nutrients for us. Unfortunately, most doctors do not remind patients that it is vital to restore the beneficial bacteria (take probiotics) when taking antibiotics.
For a graph, go to this website and click on antibiotics:
http://www.thechiropracticvillage.com/id140.htm
http://www.phototour.minneapolis.mn.us/candida/
http://www.probiohealth.com/
Search: “metagenics probiotics”
Gut 2004;53:694-700,620-622.
(20) Mg is needed as a growth factor for the beneficial bacteria, lactobacilli.
http://www.emdchemicals.com/analytics/Micro_Manual/TEDISdata/prods/1_10660_0500.html
(21) We make hydrogen from acids which react with magnesium. CoQ10 carries hydrogen into the cells. CoQ10 levels are impacted due to the decline of many nutrients, especially B6 and magnesium.
http://www.coursework.info/i/67.html
http://www.msgtruth.org/why.htm
http://www.akins.com/hh/co_q10.htm
Astrophys. J. 589, L29; L89 (2003)
http://www.lef.org/magazine/mag2001/oct2001_report_coq10_01.html
http://www.globalnutrients.net/NutraceuticalsINDEX.htm
PMID: 11401418 (www.pubmed.com)
http://www.curezone.com/foods/coenzyme_q10.htm
http://www.newswithviews.com/Howenstine/james2.htm
www.lef.org/abstracts/codex/coq10_index.htm
http://www.americanlongevity.net/misc/CoQ10_000.php
(22) With a Mg deficiency, this puts persons at risk for cancer. Our NK (natural killer cells) need Mg and Ca to do their job. This is our first line of defense against cancer. The following is no longer able to be linked, but since it was “cut and paste” note from a college lecture, I will assume it is “common knowledge” for those studying biochemistry:
“Antibody Dependent Killer (K) and Natural Killer (NK) cells (ASCC) kill by extracellular cytotoxicity by binding to a target cell and secreting cytolysins which unidirectionally kill the target cell. Once the target is bound by an NKAR and no NKIR is activated, the cytotoxic reaction occurs. The interaction of cell adhesion molecules between NK and the target cell may tighten the attachment.
The first step is a MAGNESIUM DEPENDENT movement of the cytoplasmix organelles (Golgi and granules) of the NK cell to face the target cell. The secretion of the granule contents into the intercellular space is a CALCIUM DEPENDENT step that results in the preferential insertion of perforin pores into the target cell membrane.”
See also:
http://www.mnwelldir.org/docs/immune/immune1.htm
http://www.1stvitality.co.uk/az/magnesium/
www.expage.com/energizeyourlife13
(23) As stated above (4) Bb uses acetyl-CoA (part of the cholesterol pathway). This nutrient is also needed to make the neurotransmitter acetylcholine. When one neurotransmitter is effected, it impacts the others. The body’s BALANCE is off.
Serotonin (which ultimately converts to melatonin) and dopamine (cells damaged by free radicals) are impacted. This can lead to neuro symptoms (depression, sleep problems) and more than one neurological disease. We need nutrients to make the neurotransmitters and neurohormones.
http://web.indstate.edu/thcme/mwking/nerves.html
http://www.benbest.com/science/anatmind/anatmd10.html
http://www.chemicalbalance.com/part_one_manual.htm
(24) There are other treatments used by lyme patients that indeed appear to be able to destroy this pathogen. Rife therapy and the Na-Vitamin C protocol are in this category. Still, be aware, that once the pathogen is destroyed, toxins (acids) are released and we must counter this. It is, however, my personal belief that restoring magnesium levels is the safest way to go.
To a degree, we set ourselves up for this…the inability to fight the pathogens. How? Well, the truth is our diets are harming us. As a nation, we are indeed ALREADY too low in magnesium. In the “nutritional” field, this is a well known fact. We ARE what we eat. If we continue to eat unhealthy junk foods, we will get/stay sick.
There are multiple “toxins”/acids/negative charges that we are exposed to in our environment and we must have the nutrients to combat them – the minerals - in their proper balance.
http://www.asthmaworld.org/Th1Th2.htm
Functions of Mg:
1. Make ATP (energy) by each and every cell.
2. Make all proteins…immunoglobulins (antibodies – along with calcium), hormones and enzymes (these are proteins)
3. Control OVER 350 enzymes
4. Stimulates DNA REPAIR…yes…REPAIR!
And more: http://www.mdschoice.com/elements/elements/major_minerals/magnesium.htm
Wishing you all a safe journey back to health. It IS possible.
[This message has been edited by Marnie (edited 11 August 2005).]