Marnie
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posted
Thus, the activity of rhein, the principal antimicrobial from rhubarb, was potentiated 100- to 2,000-fold (depending on the bacterial species) by disabling the MDRs (multi drug resistant pumps).
To elucidate further the molecular determinants for RXR ***repression by its antagonist***, we also determine the crystal structure of RXRαLBD-SMRT complexed with the identified antagonist rhein.
According to figure 2 the herb chinese rhubarb (rheum officinalis) is what was tested in the journal article.
Tinctures from the root of this herb are frequently used as detox agents and are mildly laxative.
Off and on over the years on a fairly frequent basis I have given hubby either rhubarb tincture (1 dropper 2 times daily) or rhubarb/butternut capsules (1 or 2 daily) to prevent constipation.
I am highly doubtful that enough of the specific chemical mentioned is available in tinctures or powdered herb to act as an efflux pump inhibitor. And at higher doses the laxative effect would probably be a problem.
Bea Seibert
Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004
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posted
I never understand Marnie Posts: 109 | From PA | Registered: Feb 2012
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
" Thus, the activity of rhein, the principal antimicrobial from rhubarb, was potentiated 100- to 2,000-fold (depending on the bacterial species) by disabling the MDRs (multi drug resistant pumps).
Comparable potentiation of activity was observed with plumbagin, resveratrol, gossypol, coumestrol, and berberine.
Direct measurement of the uptake of berberine, a model plant antimicrobial, confirmed that
***disabling of the MDRs strongly increases the level of penetration of berberine into the cells of gram-negative bacteria.***
Rhubarb can be used as a strong laxative. Its roots have been used as a laxative for at least 5,000 years.
The roots and *stems* are rich in anthraquinones, such as emodin and *rhein*. These substances are cathartic and laxative, which explains the sporadic use of rhubarb as a dieting aid.
Rhubarb roots are used in traditional Chinese medicine; rhubarb also appears in medieval Arabic and European prescriptions.
***The rhizomes ('roots') contain stilbenoid compounds (including rhaponticin), which seem to lower blood glucose levels in diabetic mice.***
But berberine does the same!!!...so no need for the "roots"...but the stalk?
Rhein: Constituent that is enriched in rhubarb with anti-inflammatory, anti-osteoarthritic, and anti-cancer activity. It *reduces* IL-1β production and secretion, caspase-3 activity, inducible nitric oxide synthase activity, and phosphorylation of c-Jun and c-Jun NH2-terminal kinase (JNK).
Rhein and berberine have some effects in common (several), but also a few differences.
Now about the rhein in the *stalk*...
Note...berberine is also slightly laxative...with berberine sulfate moreso than berberine chloride...personal experience!
Not all bad.
Bea..."google": berberine heart
You will be surprised...I promise.
[ 07-05-2012, 12:12 AM: Message edited by: Marnie ]
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lymeinhell
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posted
Is a burbur tincture just as effective?
-------------------- Julie _ _ ___ _ _ lymeinhell
Blessed are those who expect nothing, for they shall not be disappointed. Posts: 2258 | From a better place than I was 11 yrs ago | Registered: Sep 2003
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Marnie
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Member # 773
"Another berberine containing plant, Huang Lian (Coptis chinensis) has been used as an antispirochetal, where it is thought to be most commonly used herbal antimicrobial agent in China (Zhang, 2007; Chen, 2004)."
lymeinhell
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posted
Thanks Marnie. That's the brand I'm using for detox. I'll give the berberine you recommended a shot instead. I'm more interested in the treatment of insulin resistance aspect of it.
-------------------- Julie _ _ ___ _ _ lymeinhell
Blessed are those who expect nothing, for they shall not be disappointed. Posts: 2258 | From a better place than I was 11 yrs ago | Registered: Sep 2003
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Marnie
Frequent Contributor (5K+ posts)
Member # 773
posted
Be SURE you run it by your doc first and it is synergetic with whatever else you are taking!
Yes, I know...rhubarb leaves are poisonous...very.
The stalk and roots apparently have good chemicals in them.
Posts: 9424 | From Sunshine State | Registered: Mar 2001
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