Department of Pharmacology, Cell Death Disease Research Center, College of Medicine, The Catholic University of Korea, Seoul 137-701, Korea. Abstract
Aspirin (acetylsalicylic acid) is one of the most widely used therapeutic agents based on its pharmacological actions,
including anti-inflammatory, analgesic, anti-pyretic, and anti-thrombotic effects.
In this study, we investigated the effects of aspirin on seizure susceptibility and hippocampal neuropathology following pilocarpine-induced status epilepticus (SE).
SE was induced by pilocarpine hydrochloride (280 mg/kg, i.p.) administration in C57BL/6 mice (aged 8 weeks).
Aspirin was administered daily (15 mg/kg or 150 mg/kg, i.p.) for 10 days starting 3 days before SE, continuing until 6 days after SE. After pilocarpine injection, SE onset time and mortality were recorded.
Neuronal cell death was examined using cresyl violet and Fluoro-Jade staining, and glial responses were observed 7 days post SE using immunohistochemistry.
In the aspirin-treated group, the onset time of SE was significantly shortened
and mortality was markedly increased
compared to the control group.
However, in this study, aspirin treatment did not affect SE-induced neuronal cell death or astroglial and microglial responses in the hippocampus.
In conclusion, these results suggest that the safety of aspirin should be reevaluated in some patients, especially with neurological disorders such as temporal lobe epilepsy. ---------------- I use Enteric coated aspirin for many reasons.
-------------------- Suspected Lyme 07 Test neg One band migrating in IgG region unable to identify.Igenex Jan.09IFA titer 1:40 IND IgM neg pos 31 +++ 34 IND 39 IND 41 IND 83-93 + DX:Neuroborreliosis Posts: 5850 | From Kentucky | Registered: Dec 2008
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Keebler
Honored Contributor (25K+ posts)
Member # 12673
posted
- Thanks for that. Glad they are looking at aspirin again. As you point out, ENTERIC COATING is important.
Just for those new to this term: The enteric coating keeps the contents from irritating the stomach as the pill is "digested" lower down the GI tract where there is less chance of irritation.
Still, even with an enteric coating, not everyone can do aspirin. For those who can, enteric coated aspirin is FAR safer than other OTC pain relievers. [Acetaminophen can hurt the liver & lungs and decrease glutathione in our bodies. Ibuprofen can stress the kidneys.]
Enteric coating can be good for other Rx or even supplements, too. I did great with enteric coated pepperment tablets. Pepperment oil can be too strong and burn, but the enteric coating made all the difference for me and this reduced pain tremendously, all throughout my body.
Aspirin can be good to reduce inflammation but it can also eat a hole in one's stomach. A friend who took one baby aspirin a day nearly died when his stomach broke open from the erosion the aspirin did.
I'm not sure about the various kinds of enteric coatings used, but for those who must be gluten free, be sure whatever you take is certified to be gluten free, too. Some of the coatings can contain gluten (as can fillers and some capsules).
There are many other good anti-inflammatories that do not. However, I think (can't recall exactly, though) that white willow bark (from which aspirin comes) may be kinder to the stomach, especially if part of an overall formula. -
Posts: 48021 | From Tree House | Registered: Jul 2007
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