LymeNet Flash: anyone have Mannose Binding Lectin deficiency?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » anyone have Mannose Binding Lectin deficiency?

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Topic: anyone have Mannose Binding Lectin deficiency?

merrygirl
Frequent Contributor (1K+ posts)
Member # 12041

posted

Hello, haven't been here in awhile.

my doctor has found that I have severe immune deficiency.

first low Igg

now basically non existing Mannose Binding Lectin level.

deficient is less than 100.

severe is less than 50.

mine came back at <0.5

could explain a lot!

I guess the mbl issue is genetic.

haven't been told a treatment plan yet, but sounding like IVIG.

Posts: 3905 | From USA | Registered: May 2007 | IP: Logged |

desertwind
Frequent Contributor (1K+ posts)
Member # 25256

posted

Can you explain what that is? Thanks,DW

Posts: 1671 | From Tick Infested New Jersey | Registered: Apr 2010 | IP: Logged |

seibertneurolyme
Frequent Contributor (5K+ posts)
Member # 6416

posted

Merrygirl,

Had never heard of your problem before. A quick google search found some interesting results.

See the links below.

Mannose binding binding lectin is basicially needed for certain immune system functions.

Be sure and read the Wikipedia list of infections you might be more susceptible to.

And the really interesting article says that ticks secrete an inhibitor to mannose binding lectin which is one of the ways they are able to transmit lyme disease. Apparently mannose binding lectin is needed by the human immune system to fight lyme disease.

http://ghr.nlm.nih.gov/condition/mannose-binding-lectin-deficiency

http://en.wikipedia.org/wiki/Mannan-binding_lectin

http://tinyurl.com/nwkp6n3

Bea Seibert

Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004 | IP: Logged |

merrygirl
Frequent Contributor (1K+ posts)
Member # 12041

posted

MBL is part of the first line defense immune system. It is supposedly rare. On its own it isnt always an issue, but add the low Igg and its a big problem..

Bea, I am not surprised and I appreciate the information. I suspect that a lot of us with chronic lyme have this.

if you did 23andme, you can look to see if you have varients is present.

in the raw data section, you can type in MBL2 and compare the 20 or so snps.

this is also an issue with PANDAS patients.

Posts: 3905 | From USA | Registered: May 2007 | IP: Logged |

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