LymeNet Flash: I didn't know...did you?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » I didn't know...did you?

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Topic: I didn't know...did you?

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

B. burgdorferi attach to HeLa cells and

acquire cholesterol from the epithelial cell membranes.

http://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003109 2013

(HeLa cells are immortal cancer cells which are already DNA damaged and infected due to a virus - HPV - touching the cell's DNA.)

"This is in contrast to the binding to HeLa cells, where B. burgdorferi bound very well, but

***only 10 to 15% of spirochetes that bound to HeLa cells were able to achieve an intracellular location.***

This represented 2 to 5% of the total number of spirochetes added to the cultures.

This suggests that B. burgdorferi may bind to distinct receptors on different cell types, only some of which are involved in internalization, or that HeLa cells do not have the cytoskeletal structures required for the spirochete to invade.

Other invasive bacteria can invade HeLa cells, indicating that this cell type can serve as a host for intracellular localization by some bacteria.”

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC257809/

ONLY 10-15% achieve intracellular location.

IMO...10-15% too many.

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

GretaM
Frequent Contributor (1K+ posts)
Member # 40917

posted

Yikes!

Posts: 4358 | From British Columbia, Canada | Registered: Jun 2013 | IP: Logged |

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

Bb looks to attach to several cell types and *exchanges* amino acids and glucose for both to survive.

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

GretaM
Frequent Contributor (1K+ posts)
Member # 40917

posted

I was going to say, "Hmmm I remember reading this somewhere before."

And then saw my name there and realized it was me.
[bonk]

Posts: 4358 | From British Columbia, Canada | Registered: Jun 2013 | IP: Logged |

poppy
Frequent Contributor (1K+ posts)
Member # 5355

posted

At least you remembered it. Coming across a post of mine from several months back, I don't remember it. Memory like a sieve now.

Posts: 2888 | From USA | Registered: Mar 2004 | IP: Logged |

Marnie
Frequent Contributor (5K+ posts)
Member # 773

posted

B6 - active form is PLP, B3 (use niacinamide before bedtime, it is "no flush" - may have interesting dreams) and folic acid (B9)and *B12* might help. Zinc and choline play a part too...in the "methylation" cycle to drive down homocysteine.

Sublingual B complex exists, but IMO, PLP for B6 is the preferred form of that.

Re: niacin (no flush niacinamide):

http://www.sciencedaily.com/releases/2013/09/130930101836.htm

I'd like to trick my body into thinking it is exercising...

;-)

Posts: 9424 | From Sunshine State | Registered: Mar 2001 | IP: Logged |

girl
LymeNet Contributor
Member # 18022

posted

Isn't it important to use folate instead of folic acid for methylation purposes? Check this out.

http://www.tbyil.com/B6_Methionine_Folate_Lung_Cancer.htm

Posts: 631 | From the south | Registered: Nov 2008 | IP: Logged |

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