iNOS = Inducible nitric oxide synthase -> NO, nitric oxide.
Such appears to be the reaction to berberine i.e., activates Nrf2, inhibits iNOS (and MUCH more) which looks to be beneficial to fight some pathogens (and cancers), but NOT ALL.
We know that Bb has to express OspC when it goes from the tick's gut to us...when it senses "food", but also "danger".
"the downregulation of OspA requires RpoS production"
(Stress response)
elevated rpoS transcription directly correlated to
HSP60 plays an important role in the transport and maintenance of mitochondrial proteins as well as the transmission and
replication of mitochondrial DNA.
However, some new research has indicated that HSP60 possibly plays a role in a “danger signal cascade” immune response.
There is also mounting evidence that it plays a role in autoimmune disease.
HSP60 has been shown to be *released from* specific cells like peripheral blood mononuclear cells (PBMCs) when there are lipopolysaccharides (LPS) or GroEL present.
Wiki.
If it is needed for mitochondrial DNA replication, another process has to kick in to make more mitochondria (biogenesis).
In steps the dangerous IL-15:
We have shown here that ***CD8(+) memory T cells***,
SRC is the extra capacity available in cells to produce energy in response to increased stress or work and as such is associated with cellular survival.
We found that interleukin-15 (IL-15), a cytokine critical for CD8(+) memory T cells, regulated SRC and oxidative metabolism
by ***promoting mitochondrial biogenesis***
and expression of carnitine palmitoyl transferase (CPT1a), a metabolic enzyme that controls the rate-limiting step to mitochondrial fatty acid oxidation (FAO).
DPS proteins are part of a complex bacterial defense system that protects DNA against oxidative damage and are distributed widely in the bacterial kingdom.
Borrelia Dps forms a dodecameric complex capable of
Bb, it appears, sequesters iron and has a transferrin gene...iron out, so to speak - into biofilm which is where the Fe is oxidized instead of Bb's proteins.
LuxS mediates *iron-dependent* biofilm formation for “quorum sensing”
Ancora Imparo. I hope this helps those interested in understanding Bb and our response.
COX2, PGE2, miRNA-146a,suppressor macrophages, et al = even longer explanation that the above!
[ 08-16-2014, 03:11 PM: Message edited by: Marnie ]
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Razzle
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posted
So would a Hep B vaccine (does such a thing exist?) also help prevent Lyme transmission from a tick to a human?
-------------------- -Razzle Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs. Posts: 4166 | From WA | Registered: Feb 2011
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Marnie
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posted
Might.
Not yet.
One has to "grasp" the dangers of vaccines though in certain persons...genetics IS involved.
If someone is "skewed" towards a Th2 type immune response - genetically - and is given a vaccine destined to require a TH1 antibody response maybe problematic.
Besides the implications of pregnant mom...folic acid...
Here comes watching HER vitamin D level (read just the last sentence or all):
posted
Actually, I am highly skeptical of the studies by Denialists like Sigal et al where they try to imply that positive results on antibody tests showing binding to flagellar antigens (band 41 and derivatives) in patients with neuroborreliosis is due to cross-reaction with human HSP60, provoking auto-immunity.
The monoclonal antibody H9724, used by the Bowen lab to detect antigen in Lyme patients, and by Dr MacDonald in his early work with autopsy Alzheimer brain tissue, detected Borrelia infection in living and deceased patients.
The Denialists imply that these results are invalid and that it's just cross-reaction with human HSP60.
They lobbied to get Bowen lab shut down, but many patients positive on their blood test later had confirmation via other testing.
As for Dr MacDonald's results detecting borrelia in Alzhimer autopsy brain tissue with H9724, he later confirmed this using culture, PCR, and most recently - state-of-the-art Molecular Beacon DNA probes.
Bottom line - infection, not autoimmunity.
Elena
quote:Originally posted by Marnie: ...However, some new research has indicated that HSP60 possibly plays a role in a “danger signal cascade” immune response.
There is also mounting evidence that it plays a role in autoimmune disease.
-------------------- Justice will be ours. Posts: 786 | From UK | Registered: Oct 2007
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surprise
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posted
*whew* no wish to participate in your 'new theory' here Marnie, but I can't help but comment:
The Hep B vaccination (a sexually transmitted disease!) that was given to my day old daughter, who weighed 6 pounds,
was given without my knowledge in the hospital where she was born within 24 hours of her birth.
And in the year 2005, that Hep B vaccine included mercury, along with a host of insidious toxins.
It certainly did NOT prevent her congenital Lyme disease from multiplying and descending upon her body.
Ridiculous.
-------------------- Lyme positive PCR blood, and positive Bartonella henselae Igenex, 2011. low positive Fry biofilm test, 2012. Update 7/16- After extensive treatments, doing okay! Posts: 2518 | From USA | Registered: Nov 2011
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beaches
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posted
Totally agree surprise. And ditto to the Hep B vaccine not preventing my kids from becoming horribly ill with Lyme Disease.
And since when can anyone administer a shot to an infant without parental consent? Outrageous!
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surprise
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posted
Thanks Beaches for the support.
The consent for them to administer vaccines and whatnot was probably in legalese wording in the myriad of papers signed before hospital administration (and it was a planned C-section)
At any rate, I was trusting and uneducated about these sort of health issues (my much older son gratefully healthy and uncomplicated.)
It's Moms in the trenches like us who are making our real and painful experiences heard, despite media dogma to the contrary, that are making new mothers stop, pause, inform themselves, select, delay or say no, and protect their children.
-------------------- Lyme positive PCR blood, and positive Bartonella henselae Igenex, 2011. low positive Fry biofilm test, 2012. Update 7/16- After extensive treatments, doing okay! Posts: 2518 | From USA | Registered: Nov 2011
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beaches
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posted
I certainly hope the new moms are listening.
My oldest is at an age where I will have to start talking to her about all of this a some point soon. I know she will be receptive because she was so very, very sick.
It is really outrageous that in the many pages you had to sign for the c-section, there was likely hidden a page for Hep B vaccine.
That is deceptive IMO. When you are having a c-section, any and all consents should pertain to that, period.
Consents to vaccinate the baby should not be produced until after the child is born.
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posted
I've had the Hep B series of shots. Had them before I knew I had lyme and company.
Years after that series of Hep B shots, I then found out I had lyme. Which I have had for years before the Hep B shots.
When one works in healthcare, we were recommended in having the series. I never had any reactions to them, nor did they keep me from having lyme or anything with each related to each other in my opinion.
-------------------- Lyme, Babs, Fry Bug..... Whatever it is, may a treatment be discovered to make us all whole again! Posts: 941 | From AZ-MT | Registered: Oct 2004
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beaches
Frequent Contributor (1K+ posts)
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posted
hadlyme, I know those working in the healthcare field are mandated to have certain shots.
That's different from having a newborn vaccinated for Hep B shortly after leaving the womb, without an immune system.
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