Gluten sensitivity is a systemic autoimmune disease with diverse manifestations.
This disorder is characterised by abnormal immunological responsiveness to ingested gluten in genetically susceptible individuals.
Coeliac disease, or gluten-sensitive enteropathy, is only one aspect of a range of possible manifestations of gluten sensitivity.
Although neurological manifestations in patients with established coeliac disease have been reported since 1966, it was not until 30 years later that, in some individuals, gluten sensitivity was shown to manifest solely with neurological dysfunction.
Furthermore, the concept of extraintestinal presentations without enteropathy has only recently become accepted.
In this Personal View, we review the range of neurological manifestations of gluten sensitivity and discuss recent advances in the diagnosis and understanding of the pathophysiological mechanisms underlying neurological dysfunction related to gluten sensitivity.
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Another pub med article on gluten causing neuro symptoms, even dementia.
------------------------ Non-celiac gluten sensitivity triggers gut dysbiosis, neuroinflammation, gut-brain axis dysfunction, and vulnerability for dementia.
Daulatzai MA1. Author information Abstract
The non-celiac gluten sensitivity (NCGS) is a chronic functional gastrointestinal disorder which is very common world wide.
The human gut harbors microbiota which has a wide variety of microbial organisms; they are mainly symbiotic and important for well being.
However, "dysbiosis" - i.e. an alteration in normal commensal gut microbiome with an increase in pathogenic microbes, impacts homeostasis/health.
Dysbiosis in NCGS causes gut inflammation, diarrhea, constipation, visceral hypersensitivity, abdominal pain, dysfunctional metabolic state, and peripheral immune and neuro-immune communication.
Thus, immune-mediated gut and extra-gut dysfunctions, due to gluten sensitivity with comorbid diarrhea, may last for decades.
A significant proportion of NCGS patients may chronically consume alcohol, non-steroidal anti-inflammatory drugs, and fatty diet, as well as suffer from various comorbid disorders.
The above pathophysiological substrate and dysbiosis are underpinned by dysfunctional bidirectional "Gut-Brain Axis" pathway.
Pathogenic gut microbiota is known to upregulate gut- and systemic inflammation (due to lipopolysaccharide from pathogenic bacteria and synthesis of pro-inflammatory cytokines);
they enhance energy harvest, cause obesity, insulin resistance, and dysfunctional vago-vagal gut-brain axis.
Conceivably, the above cascade of pathology may promote various pathophysiological mechanisms, neuroinflammation, and cognitive dysfunction.
Hence, dysbiosis, gut inflammation, and chronic dyshomeostasis are of great clinical relevance.
It is argued here that we need to be aware of NCGS and its chronic pathophysiological impact.
Therapeutic measures including probiotics, vagus nerve stimulation, antioxidants, alpha 7 nicotinic receptor agonists, and corticotropin-releasing factor receptor 1 antagonist may ameliorate neuroinflammation and oxidative stress in NCGS;
they may therefore, prevent cognitive dysfunction and vulnerability to Alzheimer's disease.
Is gluten damaging your blood-brain-barrier, helping pathogens to get inside?
----------------------------- Gluten sensitivity research identifies a connection between gluten induced leaky gut, and leaky brain.
The ramifications of these findings are important to understand the broad scope of the impact gluten has in many diseases.
We were able to identify an intestinal Zot analogue, which we named zonulin.
It is conceivable that the zonulins participate in the physiological regulation of intercellular tj not only in the small intestine,
but also throughout a wide range of extraintestinal epithelia as well as the ubiquitous vascular endothelium, including the blood-brain barrier.
Disregulation of this hypothetical zonulin model may contribute to disease states that involve disordered intercellular communication, including developmental and intestinal disorders, tissue inflammation, malignant transformation, and metastasis.
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Gluten Damage is Under Recognized By Doctors
Most people (doctors included) connect gluten with intestinal symptoms and therefore, fail to understand the far reaching effects that gluten can have on different individuals.
The discovery of the protein zonulin has identified yet another way that gluten can create problems for those ingesting it.
It is thought that zonulin disrupts the epithelial barriers (such as found in the gut, brain, kidney, blood vessels, etc).
The disruption of the blood brain barrier could lead to a battery of different neurological and mental symptoms as this barrier is designed to keep toxic compounds out of the brain’s blood supply.
We have already linked gluten induced damage to a multitude of neurological problems including:
Schizophrenia Bipolar disease Seizure disorders Facial Palsies (i.e Bell’s) Neuropathy Nerve pain syndromes Depression ADD/ADHD Autism and other developmental disease
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Beverly
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It caused neuro symptoms for me; I could not run a register if I ate it. I wanted to work so bad and be able to function I had to stop eating it.
-------------------- God Bless You! Everything..is just my opinion. Posts: 6638 | From Michigan | Registered: Jun 2001
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I didn't know that my daughter and I had immune problems with gluten.
Only when we both fully stopped gluten, we realized we don't catch colds any more.
They stopped being a hassle from the week we stopped gluten, back in June last year.
Before, every single month, we would catch something and feel miserable for a couple of days or a whole week, sometimes.
Our energy increased considerably too.
The fact that it also stopped her muscle pains after sport, shows that gluten was causing her inflammation!!
Exactly like stated in the articles above: gluten increasing nerve inflammation and inflammation in general, helping microbes crossing all sorts of barriers.
------------------------------------------ Why people do not stop gluten?
Because of habit, addiction to gluten products.
It is a hard thing to do, at first, I agree.
But billions of people consume no gluten their whole lives (or next to nothing) specially in Asia. The staple grain is rice, gluten free.
You can have almost anything done with rice: milk, pasta, cookies, sweets.
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