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» LymeNet Flash » Questions and Discussion » Medical Questions » Why more women develop autoimmunity

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Author Topic: Why more women develop autoimmunity
Marnie
Frequent Contributor (5K+ posts)
Member # 773

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Autoimmunity risk - women:

Thus, women may be at an increased risk of M2-mediated autoimmunity due to

estrogen's ability to increase Th2 responses.

https://www.ncbi.nlm.nih.gov/pubmed/19819674

We also demonstrate that ***MSC (stem cells) IDO activity*** is implicated in the

differentiation of monocytes into interleukin (IL)-10-secreting

M2 immunosuppressive macrophages

(CD14+/CD206+).

Those monocyte-derived M2 are in turn implicated in the suppression of T cell proliferation in an IL-10-independent manner, thus amplifying the

immunosuppressive effect generated by MSC.

http://www.sciencedirect.com/science/article/pii/S1525001616304646

MSC = mesenchymal stromal cells

L-tryptophan is required for T-cell activation and

inhibition of IDO

correlated to rejection of the fetus

by the mother (Gordon et al., 2003).

http://cdn.intechopen.com/pdfs-wm/34561.pdf

IDO is an enzyme that makes tryptophan convert to KYN acid and ultimately to niacin as opposed to tryptophan -> serotonin and melatonin.

It *maybe* that Bb and C. Pneumoniae infect the MSC = our stem cells - which have a progesterone receptor on them.

There are ways to lower progesterone via Rx and even some natural nutrients and "medicinal herb oils"...

Here's one - an RX:

RU486 (mifepristone) = progesterone inhibitor

(Progesterone inhibitors = loss of a fetus.)

In the case of C. Pneumoniae (a common lyme co-infection):

These results indicate that RU486 may directly bind to the bacteria within cells and cause the destruction of C. pneumoniae."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2415806/

ONCE the infection is destroyed, there is a way to reverse the damage - safely and naturally.

You can get well.

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