LymeNet Flash: Interleukin-10 Mediated Autoregulation of Murine B-1 B-Cells and Its Role in Borrelia

LymeNet on Facebook

LymeNet on Twitter

Follow @LymeDiseaseNet

The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive

The Lyme Disease Network is a non-profit organization funded by individual donations.

»	LymeNet Flash » Questions and Discussion » Medical Questions » Interleukin-10 Mediated Autoregulation of Murine B-1 B-Cells and Its Role in Borrelia

UBBFriend: Email this page to someone!

Author

Topic: Interleukin-10 Mediated Autoregulation of Murine B-1 B-Cells and Its Role in Borrelia

Pinelady
Frequent Contributor (5K+ posts)
Member # 18524

posted

http://www.ncbi.nlm.nih.gov/pubmed/20625435
2010 Jul 6
Interleukin-10 Mediated Autoregulation of Murine B-1
B-Cells and Its Role in Borrelia hermsii Infection
B cells are typically characterized as positive regulators of the immune
response, primarily by producing antibodies. However, recent studies
...indicate that various subsets of B cells can perform regulatory
functions mainly through IL-10 secretion.

Here we discovered that
peritoneal B-1 (B-1P) cells produce high levels of IL-10 upon
stimulation with several Toll-like receptor (TLR) ligands.

High levels
of IL-10 suppressed B-1P cell proliferation and differentiation response
to all TLR ligands studied in an autocrine manner in vitro and in vivo.

IL-10 that accumulated in cultures inhibited B-1P cells at second and
subsequent cell divisions mainly at the G1/S interphase.

IL-10 inhibits
TLR induced B-1P cell activation by blocking the classical NF-kappaB
pathway.

Co-stimulation with CD40 or BAFF abrogated the IL-10 inhibitory
effect on B-1P cells during TLR stimulation.

Finally, B-1P cells
adoptively transferred from the peritoneal cavity of IL-10(-/-) mice
showed better clearance of Borrelia hermsii than wild-type B-1P cells.

This study described a novel autoregulatory property of B-1P cells
mediated by B-1P cell derived IL-10, which may affect the function of
B-1P cells in infection and autoimmunity.
-----------------------------------------
More stealth descriptions, but awfully glad to see them working on it. Go Big Blue!

--------------------
Suspected Lyme 07 Test neg One band migrating in IgG region
unable to identify.Igenex Jan.09IFA titer 1:40 IND
IgM neg pos
31 +++ 34 IND 39 IND 41 IND 83-93 +
DX:Neuroborreliosis

Posts: 5850 | From Kentucky | Registered: Dec 2008 | IP: Logged |

Printer-friendly view of this topic

The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA
http://www.lymenet.org/