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» LymeNet Flash » Questions and Discussion » Medical Questions » High Serotonin Levels - Caused by Lyme?

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Author Topic: High Serotonin Levels - Caused by Lyme?
365SunnyDays
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We hear so much about low serotonin and folks taking SSRI anti-depressants. I was recently tested and, to my surprise, I had super high levels of serotonin in my blood. My thyroid doctor suggests that this could be the cause of some of my symptoms (such as concentration issues).

Does anyone know if Lyme can cause Serotonin levels to go way up?

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We really know so little about the body and the microbiome.

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Razzle
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I don't know if Lyme can do this or not, but it wouldn't surprise me. My Brother has high serotonin and he does not have Lyme, so could be something else. I suspect genetic variants affecting brain chemistry may play more of a role than anything else...and Lyme can "switch on" or activate genetic variants.

For example, I've got a variant that increases brain levels of dopamine...I personally think this is one big factor in my chronic severe insomnia issues...I get too wound up in my brain and can't unwind and relax for sleep.

Have you asked your LLMD about this?

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-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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lymetwister
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You are OVERMETHYLATED ! This is a KPU Problem !
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Shahbah
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wow finally someone who gets interested in the subject, I posted about that last weekened and everyone seemed to think i was out of my mind....
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Shahbah
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here:
http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/105567?#000000

High serotonin is pretty much the only theory that answers a lot of questions... I just wonder one thing though: would high serotonin be harmful or is it like the immune system of the brain and GI tract?...

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Shahbah
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lymetwister, interesting document, i can see though at the bottom that there is not time for expected improvement...:-) Does that mean this is incurable?
Though I raead that serotonin levels and production decrease with age...

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chiquita incognita
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Sunny Days, are you taking any nutrient supplements? Especially, are you taking any 5htp, L theanine, tryptophan? These raise serotonin.

Are you combining any amino acids with SSRI's? This will predispose you toward excess serotonin.

The neurotransmitters in the brain are actually secreted by the gut, believe it or not. Dr Mark Hyman writes about this, I saw this in an article on the Huffington Post.

Not sure what would cause hyper-secretion from the gut, but that's something to ask your doc about.

Take care of it, excess serotonin in very advanced stages only, can be something you don't want to have. Lots of agitation et al.

Ask your doc what to do. And in the book Digestive Wellness by Elizabeth Lipski, CCN MS or in her booklet Leaky Gut Syndrome, perhaps you can find some answers.

Best, CI

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Razzle
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lymetwister,

What does it mean if one has symptoms of both over & undermethylation (based on the chart you posted)?

Just curious...

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-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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lymetwister
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I think their is a happy medium. i.e. Symptoms on both sides probably means your ok, however what are your symptoms now, I would ask. Optimally, you want to be in the middle ground, Niether Over or Under . Shabah, they just didn't reprint it, but it's still 2 mos. Minimun and more like 6-12 mos. to get it right. I can tell you from a Dr. I know personally who works just with this stuff. He says Methyl B12 and Folic acid is the main cure. I'm talking Large Doses.. Ask Kday on here.. He knows all about it after I told him about this. He will tell you how it helped him.

So where are you ? I love to Gamble, which would put me on the Undermethylation, however right now, the way I feel, I don't love to Gamble. I would think most of us are on the Overmethylated side if you really look at what is going on NOW.

I think the problem is your not Utilizing the Serotonin b/c of the blocked Pathways. Methylation is very very big and it falls under KPU. KPU is the Mothership to get everything working.

Take Thyroid as another example. T4 or Thyroxine is made from Cholesterol. Cholesterol comes from food. If you have high Cholesterol and shouldn't, you Probably have a T4 to T3 Conversion problem, thus Hypothyroid symptoms. I don't care if your labs say your TSH is fine, TSH is just one number and means squat about the Thyroid for ALL LYMIES. Not open another topic, but just trying to give another example you can relate to.

These are like Carts on Train, but the Train isn't moving.

Hope that helps..

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Shahbah
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Hi lymetwsiter, thank you for your help!!!
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Razzle
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Lymetwister,

Just PM'd you...

Thanks,

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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Shahbah
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Oh and one last question, isn't folic acid supposed to raise serotonin production?
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Shahbah
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http://foodforbreastcancer.com/news/serotonin-in-breast-cancer-cells-contributes-to-malignant-growth

High serotonin contributes to cancer... No wonder why lyme patients are more prone to developing cancer (as well as CFS patients...). I really think we should all pay attention to this problem...

Also, don't forget that 95% of serotonin is produced in the gut so the reason to this dysfunction must be in the gut rather than in the brain...

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