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» LymeNet Flash » Questions and Discussion » Medical Questions » "Big news" from our UNH Lyme research group

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Author Topic: "Big news" from our UNH Lyme research group
Al
LymeNet Contributor
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I am sending this information about two "big news" from our UNH Lyme
Disease Research Group.

1. The first one is that our "big paper" got published this week and it
had already received a lot of very positive feedbacks. The main
message from the paper is that antibiotics do not kill all forms of
Borrelia, the Lyme Disease bacteria. The previous studies only looked
at one form and when we looked at all 3 different forms of this
bacterium we have found that main antibiotics used in Lyme disease
are capable eliminating all the forms.
Here is the paper http://www.dovepress.com/articles.php?article_id=7341

2. The second big announcement is that we have our UNH conference on
May 21st 2011. It will be a half day program dedicated to present the
latest findings of our research group. We have 2 guests: two very
famous Lyme Disease Physicians: Drs. Charles R Jones and Joseph
Burrascano

The program free to the public and of course we would like to see
you!!! bests Eva

Here is the program announcement:

SAVE THE DATE
"Breakthroughs in Lyme Disease Research"
Join us to hear our news --- the latest findings of the
Lyme Disease Research Group at the University of New Haven

Saturday May 21, 1PM ~ 8PM
University of New Haven ~ Dodds Theatre
300 Boston Post Road, West Haven, CT 06516
~ Free and Open to the Public ~

Speakers to include:
Dr Charles Ray Jones- Keynote speaker
Dr Joseph Burrascano - "Recent Research Breakthroughs in Lyme Disease"
Dr Eva Sapi - "Evaluation of in vitro antibiotic susceptibility of
different morphological forms of Borrelia burgdorferi"
Graduate Thesis Research Projects:
David Luecke - "Unraveling Unique Features of Borrelia burgdorferi Biofilm"
Amy Rattelle - "Evaluation of Matrix Requirement for Borrelia
burgdorferi Biofilm Form"
Yram Foli - "Antimicrobial Effects of Medicinal Aromatic Oils on the
Different Morphological Forms of Borrelia burgdorferi"
Namrata Pabbati MS - "Novel filarial Nematode Infection in Ixodes
Scapularis ticks Collected in Southern Connecticut"

A panel discussion and networking reception will follow the presentations.


Further information: http://www.newhaven.edu/lyme

Posts: 789 | From CT, | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
Lymeorsomething
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Thanks Al. I hope I can make it to that conference.

It looks like something as simple as Amoxy and Flagyl may be a viable combo. The trick would then be to hit the biofilms too. Combining certain abx with natural protocols, like Cowden, grapefruit seed extract, etc. may be the best bet...

--------------------
"Whatever can go wrong will go wrong."

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ladyjenie
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Gee, this sounds interesting. Would love to hear this knowledge firsthand, also to learn about Medicinal Aromatic Oils.

Anything that could help treat Lyme and possibly help the Morgellon's that is relentless in making my life a lot like *ell.

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gambler
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awesome
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Al
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up
Posts: 789 | From CT, | Registered: Jun 2006  |  IP: Logged | Report this post to a Moderator
METALLlC BLUE
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I have posted the study in the thread "Persistent Infection Inspite of seemingly "adequate" antibiotics.

It is number 119, and can be found also at the very bottom of the thread presently.

--------------------
I am not a physician, so do your own research to confirm any ideas given and then speak with a health care provider you trust.

E-mail: [email protected]

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METALLlC BLUE
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For those interested in reading it directly here: my paper "The Case For Chronic Infection" chronicles these reports, and you'll find the study at the very bottom.

https://acrobat.com/app.html#d=sbb-EmpQrQTgrPoezLGreg

--------------------
I am not a physician, so do your own research to confirm any ideas given and then speak with a health care provider you trust.

E-mail: [email protected]

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Al
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Eva Sapi1
University of New Haven, New Haven, CT, USA; International Lyme and Associated Diseases Society, Bethesda, MD, USA

Background: Lyme disease is a tick-borne illness caused by the spirochete Borrelia burgdorferi. Although antibiotic therapy is usually effective early in the disease, relapse may occur when administration of antibiotics is discontinued. Studies have suggested that resistance and recurrence of Lyme disease might be due to formation of different morphological forms of B. burgdorferi, namely round bodies (cysts) and biofilm-like colonies. Better understanding of the effect of antibiotics on all morphological forms of B. burgdorferi is therefore crucial to provide effective therapy for Lyme disease.
Methods: Three morphological forms of B. burgdorferi (spirochetes, round bodies, and biofilm-like colonies) were generated using novel culture methods. Minimum inhibitory concentration and minimum bactericidal concentration of five antimicrobial agents (doxycycline, amoxicillin, tigecycline, metronidazole, and tinidazole) against spirochetal forms of B. burgdorferi were evaluated using the standard published microdilution technique. The susceptibility of spirochetal and round body forms to the antibiotics was then tested using fluorescent microscopy (BacLight viability staining) and dark field microscopy (direct cell counting), and these results were compared with the microdilution technique. Qualitative and quantitative effects of the antibiotics against biofilm-like colonies were assessed using fluorescent microscopy and dark field microscopy, respectively.
Results: Doxycycline reduced spirochetal structures ~90% but increased the number of round body forms about twofold. Amoxicillin reduced spirochetal forms by ~85%90% and round body forms by ~68%, while treatment with metronidazole led to reduction of spirochetal structures by ~90% and round body forms by ~80%. Tigecycline and tinidazole treatment reduced both spirochetal and round body forms by ~80%90%. When quantitative effects on biofilm-like colonies were evaluated, the five antibiotics reduced formation of these colonies by only 30%55%. In terms of qualitative effects, only tinidazole reduced viable organisms by ~90%. Following treatment with the other antibiotics, viable organisms were detected in 70%85% of the biofilm-like colonies.
Conclusion: Antibiotics have varying effects on the different morphological forms of B. burgdorferi. Persistence of viable organisms in round body forms and biofilm-like colonies may explain treatment failure and persistent symptoms following antibiotic therapy of Lyme disease.

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Tracy9
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It looks to me like Tigecycline and Tindamax are the best combination?

--------------------
NO PM; CONTACT: [email protected]

13 years Lyme & Co.; Small Fiber Neuropathy; Myasthenia Gravis, Adrenal Insufficiency. On chemo for 2 1/2 years as experimental treatment for MG.

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cht girl
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This makes perfect sense to me. I was on Doryx only for 5 months, had great symptom reduction. Then, was on nothing for several months, and my symptoms returned with a vengeance. Next, I tried Ceftin alone (no improvement), Zithromax (no improvement) and then started Flagyl, instant reduction in symptoms to nearly gone. So, the doryx allowed the spirochetes to turn to cyst form, and I was not on a cyst buster. Then, the flagyl killed the spirochete and cyst forms. Now, I need to learn more about how to kill the biofilm forms. Interesting!
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RDaywillcome
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beths
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I think it's either Tigecycline or Tindamax -I don't think they mean togethr, but I could be wrong.
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lpkayak
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"when we looked at all 3 different forms of this
bacterium we have found that main antibiotics used in Lyme disease
are capable eliminating all the forms"

ok-i read the study and the summary and i still don't see what combo gets 100% of Bb

i know i'm cognitively messed up...but this is really impt

could a doc or scientist or someone from UNH please make a simple statement:

to get rid of lyme disease take the following abx at what dose for how long?

--------------------
Lyme? Its complicated. Educate yourself.

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jjguitarranch
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Yeah, been thinking about that for a week:)

"to get rid of lyme disease take the following abx at what dose for how long?"

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t9im
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Hi Lpkayak:

I went to the conference at UNH with Dr. S and her presentation with the comparisons of drugs with spirochete and cyst load.

Tindamax and Doxy was the best combination. Tindamax was the best stand alone.

Unfortunatley for the time lenght used there was not 100% eliminaton of the spirochete or cyst. This is all in the test tube, in vitro, not in a host body, in vivo.

--------------------
Tim

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James1979
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Is there a video anywhere of the conference?
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