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» LymeNet Flash » Questions and Discussion » Medical Questions » Igenex results question

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Author Topic: Igenex results question
resaz
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Member # 31131

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I am reading my Igenex results and am wondering if anyone can help clarify this for me.

I have IgM 31***, 39-IND, 41*
IgG 31**, 41*, and 58*

On the results page it states:
LIMITATION: Positive result for 31 and /or 34 may be present after Lyme vaccination in uninfected persons. Infection with HSV, EBV, HCV and or syphyillis may give false (*) results

I had the Lyme vaccine years ago when I was really hiking a lot. I also have HSV.
My Dr now thinks that I no longer have Lyme but have the Dr F "bug"--I did test positive for it.
Dr F thinks that the Lyme is gone and I am now just dealing with his bug.

My question is--have any of you had the vaccine and tested positive? I only had 16 days of antibiotics and ended up in the hospital from that so I know that he is hesitant to put me on the antibiotics again as he thinks that the Lyme is gone. He's given me 2 tests since the Igenex test and they were both negative.(labcorp)
I have been treating the "bug" with a vegan low fat diet and it helped tremendously. I still have episodes where I don't feel right but Dr F says that the symptoms can be casued by the bug as well.

Thoughts?

Posts: 44 | From Phoenix | Registered: Mar 2011  |  IP: Logged | Report this post to a Moderator
Lymetoo
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How do you explain bands 41, 39 and 58??

What is HSV?

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 95340 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
kj15
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I am at the understanding that the 39 band is specific for Lyme and does not cross-react like the 31 and 34 bands can. I think I saw a few on here who were treated on that band alone.

Did you request to have the 31 Epitope test done at IgeneX to confirm whether or not your 31 band was really due to Lyme (versus another bacteria or virus)? I had this performed and it helped me believe my diagnosis. It is supposed to have a really high specificity. It was a couple hundred extra bucks, but really helped me to believe it all. I also am + for HSV and EBV so I was reluctant to believe when I saw that limitation on the test as well.

--------------------
SICK AUG 2010 / DIAGNOSED AUG 2011
LYME IGENEX WB CDC POSITIVE IGM: 31++ 34IND 39+ 41+ 83-93+
CLINICAL DIAGNOSIS: Bartonella and Babesia
REMISSION MAY 2012-DEC 2014
SEVERE RELAPSE JAN 2015
STILL WORKING SLOWLY TOWARD REMISSION AGAIN IN 2019

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ChuckG
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39 is known to cross react.
Posts: 426 | From Berkeley, CA | Registered: Feb 2009  |  IP: Logged | Report this post to a Moderator
Lymetoo
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But i would imagine that's not as likely, Chuck.

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 95340 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
Fuel1212
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Member # 29312

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I have never heard of 39 cross reacting? Not to say that it can't.

9 cross-reactive for Borrellia
12 specific for Bb
18 unknown
20 cross-reactive for Borrellia
21 unknown
22 specific for Bb, probably really the 23/25 band
23-25 outer surface protein C (OspC), specific for Bb
28 unknown
30 unknown; probably an outer surface protein; common in European and
one California strain
31 outer surface protein A (OspA), specific for Bb
34 outer surface protein B (OspB); specific for Bb
35 specific for Bb
37 specific for Bb
38 cross-reactive for Bb
39 is a major protein of Bb flagellin; specific for Bb
41 flagellin protein of all spirochetes; this is usually the first to appear after a Bb infection and is specific for all Borrellia
45 cross-reactive for all Borellia (sometimes people with Lyme who have
this band positive also have the co-infection Ehrlichiosis)
50 cross-reactive for all Borrellia
55 cross-reactive for all Borrellia
57 cross-reactive for all Borrellia
58 unknown but may be a heat-shock Bb protein
60 cross reactive for all Borrellia
66 cross-reactive for all Borrelia, common in all bacteria
83 specific antigen for the Lyme bacterium, probably a cytoplasmic membrane
93 unknown, probably the same protein in band 83, just migrates differently in some patients

--------------------
IgM- 31,34,39,83-93 IND
IgM- 41+

IgG- 31,34,39,83-93 IND
IgG- 41++

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resaz
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I know that I cannot explain away the other ones I was positive on, I was just wondering about the 31 b/c of the specific statement about the vaccine.

I am going to try to get a second opinion about the idea of the Lyme being "gone" as Dr F says. I do believe that there is something to the FL1953 though. When I started the diet I had tremors, stomach pain and intense fatigue. I had a few days of feeling really icky and then I felt a LOT better and have felt much better for the past few months. I have "flares" around my cycle but Dr F says that this is the FL1953.
As I said, he says I no longer have Lyme so he will not put me on meds for Lyme since I tested negative 2ce both western blot and PCR.

I just did not know too if anyone had also had the vaccine and had a positive too.

Posts: 44 | From Phoenix | Registered: Mar 2011  |  IP: Logged | Report this post to a Moderator
   

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