LymeNet Flash: Is Milk Thistle contraindicated while taking Rifampin?

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»	LymeNet Flash » Questions and Discussion » Medical Questions » Is Milk Thistle contraindicated while taking Rifampin?

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Topic: Is Milk Thistle contraindicated while taking Rifampin?

bcb1200
Frequent Contributor (1K+ posts)
Member # 25745

posted

Hi folks:

I've read how Milk Thistle down-regulates the CYP3A4 liver pathway and how Rifampin up-regulates it..the net effect is a higher than anticipated build up of Rifampin in the body which can cause liver damage.

Check out this old thread http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/105004?

How many here have taken Milk Thistle with Rifampin?

I wonder if this was the reason my liver counts went sky high when I was on it.

--------------------
Bite date ?
2/10 symptoms began
5/10 dx'd, after 3 months numerous test and doctors

IgM Igenex +/CDC +
+ 23/25, 30, 31, 34, 41, 83/93

Currently on:

Currently at around 95% +/- most days.

Posts: 3139 | From Massachusetts | Registered: May 2010 | IP: Logged |

Jane2904
Frequent Contributor (1K+ posts)
Member # 15917

posted

Daughter took milk thistle while on Rifampin.

She had abnormal Liver values once early in treatment. We added in small amount of Milk Thistle and never had another problem.

Posts: 1357 | From Massachusetts | Registered: Jun 2008 | IP: Logged |

rockette
Junior Member
Member # 33599

posted

OMG I just read about this too. Not going to take MT while on the rifampin

Posts: 7 | From CT | Registered: Aug 2011 | IP: Logged |

scorpiogirl
Frequent Contributor (1K+ posts)
Member # 31907

posted

I am but I take mine at midnight or 1 am. So at least 5-6 hours away from Rifampin. My LLMD said to be sure to take everything at least 2 hours away from Rifampin. So far so good... my liver enzymes and Bilirubin has been fine. I have more lab work tomorrow so I guess we'll know more on Wednesday.

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Posts: 1391 | From Lyme Land | Registered: May 2011 | IP: Logged |

nonna05
Frequent Contributor (1K+ posts)
Member # 33557

posted

It changes what a lot of your meds do/////Check drug interaction chart...My doc said just swig 4-6 oz. of grapefruit juice ,a day while on it.. [Eek!]

Nonna

Posts: 2563 | From Denver,CO | Registered: Aug 2011 | IP: Logged |

joysie
LymeNet Contributor
Member # 11063

posted

i have been taking it all along.....Rifampin does change everything.

Posts: 520 | From Maryland | Registered: Jan 2007 | IP: Logged |

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