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» LymeNet Flash » Questions and Discussion » Medical Questions » Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline

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Author Topic: Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline
Dave6002
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Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptomsthe Beyond Ageing Project: a randomized controlled trial

Background: Evidence remains unclear as to whether folic acid (FA) and vitamin B-12 supplementation is effective in reducing depressive symptoms.

Objectives: The objective was to determine whether oral FA + vitamin B-12 supplementation prevented cognitive decline in a cohort of community-dwelling older adults with elevated psychological distress.

Design: A randomized controlled trial (RCT) with a completely crossed 2 2 2 factorial design comprising daily oral 400 μg FA + 100 μg vitamin B-12 supplementation (compared with placebo), physical activity promotion, and depression literacy with comparator control interventions for reducing depressive symptoms was conducted in 900 adults aged 6074 y with elevated psychological distress (Kessler Distress 10Scale; scores >15).

The 2-y intervention was delivered in 10 modules via mail with concurrent telephone tracking calls.

Main outcome measures examined change in cognitive functioning at 12 and 24 mo by using the Telephone Interview for Cognitive StatusModified (TICS-M) and the Brief Test of Adult Cognition by Telephone (processing speed); the Informant Questionnaire on Cognitive Decline in the Elderly was administered at 24 mo.

Results: FA + vitamin B-12 improved the TICS-M total (P = 0.032; effect size d = 0.17), TICS-M immediate (P = 0.046; d = 0.15), and TICS-M delayed recall (P = 0.013; effect size d = 0.18) scores at 24 mo in comparison with placebo.

No significant changes were evident in orientation, attention, semantic memory, processing speed, or informant reports.

Conclusion: Long-term supplementation of daily oral 400 μg FA + 100 μg vitamin B-12 promotes improvement in cognitive functioning after 24 mo, particularly in immediate and delayed memory performance.

This trial was registered at clinicaltrials.gov as NCT00214682.

Posts: 1078 | From Fairland | Registered: Apr 2006  |  IP: Logged | Report this post to a Moderator
seibertneurolyme
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And we have to wonder what the results would have been at higher doses of supplements.

Hubby takes 5000 mcg of sublingual B12 once daily -- in the past took 3 times that until B12 levels got into optimum range.

He also takes 4800 mg of folinic acid (activated folic acid) to correct his genetic methylation problem.

Bea Seibert

Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004  |  IP: Logged | Report this post to a Moderator
   

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