1.) Supporting thyroid function (sugar, protein, saturated fats):
"The low carbon dioxide production of hypothyroidism (e.g., Lee and Levine, 1999), and the respiratory alkalosis of estrogen excess, are often overlooked." - Ray Peat
“The basal metabolic rate (B.M.R.) is the oxygen consumption (or CO2 production, or heat production) under fasting conditions (to eliminate specific dynamic action of food), absolute rest (to eliminate increased caloric requirements for muscular work) and at normal room temperature (to eliminate variations in caloric requirements for the maintenance of normal body temperature).” - Hans Selye (The Textbook of Endocrinology 1947)
2.) Consuming a high ratio of dietary calcium (and calcium cofactors) to phosphate (milk, cheese, eggshell calcium):
"An adequate supply of calcium, and sometimes supplementation of salt and baking soda, can increase the tissue content of CO2." - Ray Peat
"PTH (like estrogen and serotonin) inhibits cellular respiration and activates glycolysis, lowering the ATP level and shifting the cells metabolism toward the production of lactic acid rather than carbon dioxide. PTH also causes bicarbonate to be lost in the urine." - Ray Peat
"With aging, cells have less ability to produce energy, and are often more easily stimulated. The accumulation of polyunsaturated fats is one of the factors that reduce the ability of the mitochondria to produce energy (Zhang, et al., 2006, 2009; Yazbeck, et al., 1989). Increased estrogen exposure, decrease thyroid hormone, an increased ratio of iron to copper, and lack of light, are other factors that impair cytochrome oxidase enzyme." - Ray Peat
4.) Consuming various other nutrients—especially magnesium and vitamin B1 (coffee, seafood, egg yolks, liver):
"The features of the stress metabolism include increases of stress hormones, lactate, ammonia, free fatty acids, and fat synthesis, and a decrease in carbon dioxide. Factors that lower the stress hormones, increase carbon dioxide, and help to lower the circulating free fatty acids, lactate, and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), sugar (to reduce cortisol, adrenaline, and free fatty acids), salt (to lower adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976)." - Ray Peat
5.) Minimizing Unsaturated fat intake (to support the stability of cardiolipin and the function of cytochrome c oxidase).
6.) Minimize the release of serotonin, estrogen, and the absorption of endotoxin (reasons listed above).