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» LymeNet Flash » Questions and Discussion » Medical Questions » Article: Salt key in new drug for Malaria from "Brisbane Times"

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Author Topic: Article: Salt key in new drug for Malaria from "Brisbane Times"
lymetwister
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http://www.brisbanetimes.com.au/national/salt-key-in-new-drug-for-malaria-20130214-2efr8.html

I'm sure all the Salt/C folks will like this article. Was sent to me, so I thought I would share.

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Catgirl
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Fascinating Lymetwister! Maybe this helped to knock my babs down (salt/c).

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poppy
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Well, if a parasite has a salt pump, just adding salt will not work. It will just be removed. The drug they mention stops the salt pump itself.

This sounds similar to the efflux pumps of borrelia which kick out some antibiotics.

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micul
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Don't expect anything soon; they've been working on this approach for about 7 yrs. This article is dated 2006. I saved this link to my files about 5 yrs ago, and have been waiting for something, but still nothing.


ScienceAlert - Australia & New Zealand ScienceAlert - Satellite Image

Malaria's taste for salt E-mail to a Friend
Thursday, 28 September 2006
Australian National University

"New research on how the malaria parasite survives inside the cells of humans could potentially lead to better treatments for the worldwide disease.

Published in Nature today, a team based at The Australian National University revealed why the malaria parasite - Plasmodium falciparum - increases the sodium, or salt, content inside its hosts red blood cells.

Once theyve infiltrated their human host, malaria parasites hide inside the red blood cells to avoid being detected by the immune system, explained Dr Kevin Saliba, a Medical School lecturer based in the School of Biochemistry and Molecular Biology (BaMBi) at ANU.

Scientists have known for some time that once inside the red blood cell, the parasite alters the balance of ions in their host cell, increasing the amount of sodium. Until now it has not been clear whether this is something that is actually important for the parasite. What weve shown is that the increased sodium plays a crucial role in the mechanism by which the parasite takes up a key nutrient, Dr Saliba said.

Dr Rowena Martin, another member of the BaMBi team, described how they have discovered a protein that enables the parasite to exploit the increased sodium levels inside the red blood cell, using the sodium to fuel the uptake of phosphate, a substance required by the parasite for a whole range of biochemical processes.

The parasite needs phosphate to survive. The protein we have described binds to sodium and phosphate in the host blood cell and transports them, together, into the parasite Dr Martin said.

This research has revealed yet again just how cunning this parasite is. It manipulates the salt content of its host blood cell and then uses what is essentially a salt-powered vacuum cleaner to steal a key nutrient from its host, BaMBi head Professor Kiaran Kirk said. If we could block this system we could starve the parasite to death, and this could well be the basis for a new antimalarial therapy, Professor Kirk said.

Professor Kirk and Associate Professor Stefan Broer were senior authors on the Nature paper, which also included input from scientists at the University of Melbourne. The research team received funding from the Australian Research Council and the National Medical Health Research Council."
Editor's Note: Original news release can be found here.

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droid1226
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Lymetwist, didn't you try salt C for a while? How'd you fare on it?

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emla999/Lyme
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quote:
the malaria parasite - Plasmodium falciparum - increases the sodium, or salt, content inside its hosts red blood cells.

So, the malaria parasite actually causes an increase of sodium to occur in your red blood cells. And the parasite uses sodium to "steal" other nutrients such as phosphate from our body.


So, in away, the malaria parasite is using sodium for it's survival. That is interesting!!


I wonder if other parsites besides malaria can use sodium for their survival or use sodium to steal nutrients from our body?


.

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glm1111
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Great find lymetwister!

QUOTE
"The parasite fills up with salt and dies" Sound similar to what the salt does to other parasites/worms.

With worms, the salt puts them into osmotic shock and dehydrates the worms. This explains why I don't have any more babs symptoms since I have been doing salt/c beginning in 2006.


The people that are most succesful with the salt/c protocol are those that stay on it. I also have read that some of the antiparasitic herbs such as cloves kills babesia. Thanks for posting G.

Gael

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annxyzz
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So does the salt feed ( fertilize) and enable the parasite , or KILL it ?

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annxyzz

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emla999/Lyme
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Actually, the malaria parasite uses sodium to it's advantage via it's sodium/salt pump. So taking salt alone will do nothing.


Please read Micul's post above.


Also Lyme Twisters, article stated that a new antimalarial drug, fortuitously, targeted these salt pumps. And as soon as they added the drug , the parasite fills up with salt and dies. Thus, the drug inhibited the parasite from using sodium to it's advantage the way that it normal uses sodium to it's advantage.


Again, the malaria parasite uses sodium for it's survival via it's built in sodium pump.


But that drug prevented the malaria parasite from using sodium the way that it normally does by inhibiting the malaria parasites sodium pump.


The malaria parasite normally uses sodium to hurt it's host but this drug prevents this from occuring by damaging the malaria parasite's sodium pump which prevents the malaria parasite from ridding it's self of sodium.


.


.

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glm1111
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Yeah annx,

I thought that was confusing as well. From what I am gathering (anyone correct me if this is wrong) they need the salt to survive, but if they have an "overdose" it fills up the whole organism because they can't handle that much and they die.

Gael

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annxyzz
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Maybe there will be hope for all of us in time .

Gael, do you really think cloves can target babesia ? I know you think they prevent egg multiplication .

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annxyzz

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emla999/Lyme
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Yes, it appears as though the malaria parasite needs sodium to survive.


And normally, the malaria parasite will "pump" out sodium via it's built in sodium pump into it's hosts RBC. So, sodium by itself will not harm the malaria parasite because it can normally just pump the sodium out into your RBC.


And if anything, the malaria parasite would normally love sodium because it can use sodium against it's host.


But this new drug prevents the malaria parasite from using sodium the way that it normally does.


Now, maybe Vitamin C has a similar effect as that new drug does on parasites built in sodium pump. That's just a thought but I don't know whether it does or not.


.

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glm1111
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annx,

I am JUST finding this info about cloves killing malaria. When I googled "does eugenol kill malaria" the Humaworm sight came up and said that cloves are tremendously effective in killing malaria, TB, cholera, scabies and other parasites. As many times that I have viewed the Humaworm sight, I didn't read this part.

I have been mixing lots of extra cloves in with my herbs. So, maybe that's why the combo of the salt/c and antiparasitic herbs have been so effective for me.

Gael

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PARASITES/WORMS ARE NOW
RECOGNIZED AS THE NUMBER 1 CO-INFECTION IN LYME DISEASE BY ILADS*

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lymetwister
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Simple answer is to put Salt on a worm next time it rains or a slug, what have you and see what happens to it.

No difference inside the body.

Yes, I did this protocol for a while, but stupid me didn't stick with it b/c I Herx'd like the Devil on it just like everything else. It's so simple and effective for those that stick it out.

I'm trying some things that go after Babesia right now like the Coartem and I have some Ivermectin that should be here in the next week. I'll hit myself up with those two for a bit and see what happens. The Coartem Herx'd me to Hell and back, well, I'm still on my way back as I just finished round 2, 24 hours ago.

Salt/c is in my Arsenol and I will hit the Bast***s from every angle from here on out. No more long breaks. Western medicine is where I came from so even though I put together those great Salt/c Videos early on, I did the PICC line for about 1 1/2 years only to get 10 x worse.

Gael has got me refocused. I do still think the Immunocal is very important for Detox and I'm still doing that as well. I will just plan on Herxing for the next year.

God knows I've seen every episode of Cops, Dateline, Snapped, 60 Minutes, Pawnstars (All seasons), Supernatural (All Seasonsons), etc. :-)

Best to everyone ...... Gary

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emla999/Lyme
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quote:
Simple answer is to put Salt on a worm next time it rains or a slug, what have you and see what happens to it.


No difference inside the body.




What happens to a worm when you pour salt onto it does not represent what happens to a parasite or worm that inside of your body when you eat salt.


When you pour salt on to a worm it creates a hypertonic environment around that worm causing water to flow out of it (dehydration). And thus the worm dies of dehydration due to the hypertonicity.


But most of your bodily fluids are isotonic , not hypertonic (urine can be hypertonic though). For example your blood, tears and lymph fluid are isotonic. And your body always tries to keep those bodily fluids isotonic. And your blood must be kept isotonic.


If your blood was hypertonic then you would feel very bad or worse you may die.


Now, if you eat or drink something that is hypertonic your body will try to take steps to prevent the rest of your bodily fluids from also becoming hypertonic.


So, your body may cause you to pee out the excess salt or you will usually become thirsty and by ingesting more water you will prevent most of your bodily fluids from becoming hypertonic. When you add the right amount of water to a hypertonic solution you will thus create an isotonic solution.


So, when you eat salt, your body will usually take steps to prevent your body from becoming hypertonic. And therefore, what happens to a worm when you pour salt onto it does not represent what happens to a parasite or worm that inside of your body when you eat salt.


.

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glm1111
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emla,

What happens to a parasite inside of your body appears to be exactly what lymetwister describes in reference to the worm drying out.

If you look at the www.lymephotos.com site you can actually see the salt cyrstals surrounding the parasites on some of the pictures and the description of it.

I can also attest to this personaly because when some of the parasites emerged through my skin, you can actually "see" the salt crystals on the scab.

Gael

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PARASITES/WORMS ARE NOW
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emla999/Lyme
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That article that Micul posted stated that the malaria parasite increases sodium, or salt, content inside of its hosts red blood cells. And that increased sodium plays a crucial role in the mechanism by which the malaria parasite takes up a key nutrient.... phosphate.


So, the malaria parasite uses sodium to survive. And thus eating just salt by itself should have no effect upon the malaria parasite.


You can read that article by clicking on the link down bellow.


Malaria's taste for salt


http://www.sciencealert.com.au/news/20062809-6417.html


Also, if eating salt killed worms and parasites that easily then why do livestock farmers routinely "deworm" their livestock using anti-parasite drugs.


I have spent much of my life around livestock. And salt lick blocks are commonly and routinely provided to livestock. But eating alot of salt does not seem to prevent livestock from getting worms or cure a parasite/worm infection in livestock.


http://tinyurl.com/armntmm


http://tinyurl.com/becagsx


http://www.tractorsupply.com/livestock-salt/american-stockman-white-salt-brick-50-lb--2516502


Maybe the combination of salt and Vitamin C would. But in my experience pure salt does not.


And pouring salt directly onto a worm or a slug kills worms by dehydration via hypertonicity aka high osmolarity of the cells.


Hypertonic = high osmolarity


And hypertonicity (high osmolarity) cannot occur inside of all human bodily fluids without a person having severe side effects.


Sea water is hypertonic, if you drink nothing but seawater you will not live long because humans cannot live when all of their bodily fluids are hypertonic.


So, it is not practical and probably not safe for you to ingest enough salt to cause your bodily fluids to become hypertonic and therefore have a high enough osmolarity to kill parasite in all bodily fluids.


And since salt kills worms by causing dehydration via hypertonicity/high osmolarity you probably could not ingest enough salt to kill worms because you would probably develop severe side effects or death from having hypertonic blood.


And usually if your body detects that all of your bodily fluids are becoming hypertonic then you will start to crave water. Drink water can help top prevent hypertonicity of bodily fluids.


At all times, the body tries to keep the osmolarity of the most important bodily fluids such as blood from becoming hypertonic. Blood must be isotonic.


But if you were to ingest enough salt to cause your blood to become hypertonic then you could probably kill alot of worms inside your body but unfortunately you would probably also kill yourself in the process or at thje very least you would become very ill.


Now, with that being said, the combination of salt and Vitamin C may very well kill parasites inside of the body. But if that combination does kill parasites inside of the body then it's probably not due to the same reason as worms dying from salt being poured onto them.


.

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glm1111
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emla,

The salt licks cows used to be given were pure sodium chloride. More recently, the salt licks they are given have been mineralized with minerals, vitamins and medicine, diluting the original sodium chloride strength.

The vitamins can actually feed the parasites. The malaria parasite may use salt to survive, however if it ingests too much it will kill it. Humans eat food to survive, but if we eat too much we can become sick!

Without getting into more theory about becoming hypertonic which is not what is being referred to with salt/c,

Ingesting enough salt safely, and drinking water to balance the fluids, the parasites are definitely becoming dehydrated.

I can only say, that "seeing" the salt around the parasites and "seeing" them scabing and drying out is proof enough for me. "Seeing is believing"

P. S. Vitamin C does not produce salt cyrstals.

Gael

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PARASITES/WORMS ARE NOW
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emla999/Lyme
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Here are a couple of examples of the salt blocks that we have gotten.


http://www.southernstates.com/catalog/p-948-champions-choice-white-salt-block-50lb.aspx


http://www.tractorsupply.com/livestock-salt/american-stockman-white-salt-brick-50-lb--2516502


The label on the last salt block that I looked at said 99.88% salt/sodium chloride. So, the salt blocks that we have used are nearly 100% sodium chloride. And alot of livestock farmer around here use those same blocks. But the majority of them still have to use anti-parasite meds to deworm their livestock.


My grandparents and great grandparents used those exact same salt blocks. And the livestock still often had to be given anti-parasite meds of some sort.


And NO, salt by itself does not kill the malaria parasite in the human body. In the human body, sodium by itself cannot kill the malaria parasite because the malaria parasite has a sodium pump that pumps salt into RBC's. Sodium helps the malaria parasite to get something that it needs to survive.... phosphate.



What killed the malaria in that article was the anti-malarial drug.


That new drug inhibited the malaria parasite's sodium pump and thus the malaria parasite could not pump the sodium into the the blood cells of it's host to get the phosphate that it needs to survive.


If it wasn't for that anti-malarial drug's inhibition of the malaria parasite's sodium pump then the malaria parasite would not have been killed by the sodium.


.

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Catgirl
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I doubt cows or people who are not on the salt/c protocol have nearly as much salt as a person on this protocol. The malaria parasite may not be able to handle the load of salt that a person on this type of protocol ingests regardless of the body's ability to deal with some salt.

I would think the salt/c protocol and also babs meds and herbs could only help. Especially after all Gael said above. The salt may stress the malaria parasite enough so that it cannot adequately pump fast enough while trying to protect itself from the meds and herbs at the same time.

Gael has had success on this protocol. She even said she saw salt crystals around some exiting parasites. That's good enough for me.

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annxyzz
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Gael, I ordered cloves today . I am taking herbs for babs and lyme and will see if cloves make any difference . I am not strong enough to throw salt in yet - if I did I would sleep forever !

I hope the cloves do something - worth a try . I definitely believe this turned you around . Unfortunately it seems everything we try works for some and not for others . I am also trying a tincture of black walnut and wormwood . I have not tied this in years .

Who knows , maybe the cloves are making the salt work?! I know clove OIL kills scabies on the skin , maybe clove powder kills the parasite, not just the egg . Would that not be amazing ?

Sometimes I feel that the answer will be something very simple that was in our face obvious .
May God help us all !

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Catgirl
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Annxyzz, Gael reminded me about cloves a few months ago. I just sprinkle some in some water and down it. It really does help. :)

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annxyzz
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Thank you catgirl !

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lymetwister
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It's a Temporary state of Hypertonisity. Yes, the body gets back to Homeostasis, but if you google the term Hypernatremia, this is where one sits for a bit on Salt/c protocol. I think this is what the Article was trying to say, only they want to take Salt and put it in a pill and sell it, thus the verbage is confusing, but the effect is the same.

No different than when I Herxed from Popcorn after my daughter killed me with Salt. It ate the entire bag that way in about 30 min. I Herxed like crazy from probably what equated to about 3-4gm of Table Salt, which is not the way to do Salt/c, but it was my way that night :-( .

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cozynana
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This is so interesting. I have BB and love salt. I eat only I eat only Salt brand of salt.

Is there any difference? I just had lab work done and most times I have it done my BUN is up a bit

and they tell me it is probably because I am a little dehydrated. I drink a huge amount of water.

I have always wondered if the parasites were using and absorbing my water, leaving me short.

I am on Art at the present and think I will start on salt/c next.

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emla999/Lyme - thank you for all your wonderful information!
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