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» LymeNet Flash » Questions and Discussion » Medical Questions » Antibiotics make my thyroid hormones worse

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Author Topic: Antibiotics make my thyroid hormones worse
Indica440
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As the title says, im feeling that im hypothyroid because of the antibiotics. Im currently taking ERFA thyroid. Doxy and Diflucan is the combo my doc put me on... Ever since i started Doxy/Diflu i felt more cold, now its very clear that i get hypothyroid from it because i take even more ERFA and i still feel very cold in the evening.

Did someone else experience this? I know Dr.Herthoge claims that antibiotics are not good iff you supplement hormones because they seem to "block" them... i dont know if this is true, all i know is i feel hypo.

Posts: 141 | From cali | Registered: Nov 2012  |  IP: Logged | Report this post to a Moderator
faithful777
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Yup!! I found it harder to regulate my thyroid on the abx. I had to raise my thyroid meds and also add cytomel several times a day.

Never heard that abx blocks hormones though. I find you have to compensate sometimes with raising the dose but once off abx, you may be able to reduce your dose.

--------------------
Faithful

Just sharing my experience, I am not a doctor.

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Indica440
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how much cytomel did you add?
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Lymetoo
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Some abx block estrogen. Remember?? They warn about taking abx when on birth control.

(I think it was doxy, but not sure.)

--------------------
--Lymetutu--
Opinions, not medical advice!

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Indica440
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im a guy [Big Grin]
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BuffyFan
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I was off antibiotics for six months and still couldn't get my thyroid levels to optimal level.
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Lymetoo
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quote:
Originally posted by Indica440:
im a guy [Big Grin]

-
[Big Grin] I was referring to what faithful said. ("Never heard that abx blocks hormones though.")

--------------------
--Lymetutu--
Opinions, not medical advice!

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Indica440
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they seem to interact with the hormones somehow. maybe it has to do with inflammation i dont know. its really weird. buffy what do you mean? have you tryed T3 ?
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emla999/Lyme
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Yes, certain antibiotics are known to alter thyroid hormone production. Some antibiotics can potentially lower thyroid hormone production. While other antibiotics can potentially increase thyroid hormone production.


Do antibiotics make thyroid symptoms worse?

http://tinyurl.com/bp8t78n


The antibiotic Rifampin may induce hypothyroidism


http://www.ncbi.nlm.nih.gov/pubmed/16957414


Sulfa based antibiotics can affect thyroid function[/b]


http://tinyurl.com/azxklyd


Giving Flagyl to a hypothyroidism patient is contradictory because Flagyl can lower thyroid hormones.


http://tinyurl.com/a2f9t6c


Flagyl (metronidazole) inhibits thyroid function

http://www.sciencedirect.com/science/article/pii/S0026049565800282


"These findings in rats are consistent with the claim that metronidazole inhibits TSH secretion and thyroid function in man"


Lariam (mefloquine) may a play a role in the development of hypothyroidism


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC101408/


The antibiotic Ciprofloxacin has been shown to significantly increase the production of T3 and T4 thyroid hormones...... at least in rats it has. And Ciprofloxacin's ability to increase the production of thyroid hormones was increased by taking certain vitamins concurrently with Ciprofloxacin.


http://tinyurl.com/cd4ed69


But on the other hand the antibiotic Ciprofloxacin may also inhibit the absorption of thyroid medication when oral thyroid medication is taken at the same time as Ciprofloxacin.


http://www.ncbi.nlm.nih.gov/pmc/articles/PMC557149/


Also, even other antibiotics such as Amoxicillin and Augmentin can potentially affect thyroid hormone function.


http://tinyurl.com/bp8t78n


"After release from the thyroid gland both T4 and T3 are bound to the transport proteins in the blood. So does Synthroid, a synthetic T4. Approximately 99% of the circulating thyroid hormones are bound to the blood proteins. Only 1% of thyroid hormones is unbound. Only unbound thyroid hormones are biologically active.


The protein bound hormons are inactive. Most of the thyroid hormones are bound to the thyroid-binding globulin (TBG), a special carrier protein for T3/T4. A smaller fraction of the thyroid hormones is bound to different blood proteins, such as prealbumin and albumin. Many antibiotics are also bounded (attached) to albumin and other transport proteins in the blood.


Therefore, antibiotics compete with thyroid hormones for the same transport proteins (i.e. albumin). When antibiotics get into the blood, some amount of the thyroid hormones (or Synthroid) may detach from the albumin and become biologically active, causing HYPERthyroid symptoms. So, the more antibiotic binds to the serum proteins, the more thyroid hormons may become unbound and active.


So, the more antibiotic binds to the serum proteins, the more thyroid hormones may become unbound and active. "


So, when someone takes an antibiotic and they feel worse (or better) it may not always be due to the killing off of bacteria in the body but it may be due to the changes that antibiotics can potentially have on thyroid hormone production.


.

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