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» LymeNet Flash » Questions and Discussion » Medical Questions » Do I have Lyme or not???

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Author Topic: Do I have Lyme or not???
TallyFL
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Member # 42566

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I have been sick for over a year. I finally went to a ND to see if she could help because my Doctor's couldn't. She tested me for Lyme and when the results came back, she said I did, in fact, have Lyme. I took the paperwork to my Primary Care and he says that I do not. Can someone shed some light? Here is the lab results:


Western Blot -


All IgG - ABSENT


IgM p23 - Present


according to my PC, I don't have enough criteria. So why would one band be positive? Is this just random??


Any help would be appreciated as I am so confused. thank you.

Posts: 5 | From Tallahassee, Florida | Registered: Oct 2013  |  IP: Logged | Report this post to a Moderator
droid1226
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post all results unless you're saying they are all negative. IND is interpreted as a positive to most lyme dr's

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Posts: 1181 | From ohio | Registered: Nov 2011  |  IP: Logged | Report this post to a Moderator
Lymetoo
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Member # 743

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Which lab?

Band 23 is Lyme specific. Nothing else can cause it to show up.

Please print this out and read it several times:

Western Blot Explanation
http://flash.lymenet.org/ubb/ultimatebb.php/topic/1/42077

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--Lymetutu--
Opinions, not medical advice!

Posts: 95208 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
TallyFL
Junior Member
Member # 42566

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I'll read it, thanks! my labs:

Lyme, Western Blot, Serum
IgG P93 - absent
IgG P66 - absent
IgG P58 - absent
IgG P45 - absent
IgG P41 - absent
IgG P39 - absent
IgG P30 - absent
IgG P28 - absent
IgG P23 - absent
IgG P18 - absent

Lyme Ab IgM by WB:

IgM P23 - PRESENT
IgM P41 - absent
IgM P39 - absent

Posts: 5 | From Tallahassee, Florida | Registered: Oct 2013  |  IP: Logged | Report this post to a Moderator
sickofsick
LymeNet Contributor
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My daughter also had only band 23 on first Western Blot. Four Lyme literate docs have agreed that is enough for a diagnosis. Of course other testing has supported the diagnosis. I feel very confident that she has tick-borne illnesses. I have always felt that perhaps her Lyme is different (different strain or whatever) so it doesn't react the same.

Your PCP is likely following inadequate CDC testing guidelines that require more bands (5/10 IgG, 2/3 IgM). But any doctor experienced at interpreting results will say even one Lyme specific band indicates Lyme exposure.

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Catgirl
Frequent Contributor (5K+ posts)
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Yeah, you have it. Band 23 only comes up with lyme. Once you start treating for it, other bands will pop up.

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--Keep an open mind about everything. Also, remember to visit ACTIVISM (we can change things together).

Posts: 5418 | From earth | Registered: Mar 2011  |  IP: Logged | Report this post to a Moderator
Lymetoo
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Which lab?

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 95208 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
miyamotoi
Member
Member # 41833

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quote:

Lyme, Western Blot, Serum
IgG P93 - absent
IgG P66 - absent
IgG P58 - absent
IgG P45 - absent
IgG P41 - absent
IgG P39 - absent
IgG P30 - absent
IgG P28 - absent
IgG P23 - absent
IgG P18 - absent

Lyme Ab IgM by WB:

IgM P23 - PRESENT
IgM P41 - absent
IgM P39 - absent

This looks like a Labcorp Format...

How long have you been ill? Very generally, IgG is typically the long last antibodies while IgM suggests your immune system believes its a new infection.

Labcorp seems to have a very poor track record. Many people report Labcorb showed no bands while another lab showed many. Like me.

23 is OspC which is suspicious since its a primary Borrelia surface protein. There are however cross reacting antibodies but its worthy of finding a better lab.

If you have reason to believe you might have Lyme, try a more reliable lab such as:

Igenex, Imugen and StonyBrook use multiple strains in their Blot antigens which improves the tests sensitivity across strains..

Posts: 51 | From California | Registered: Aug 2013  |  IP: Logged | Report this post to a Moderator
miyamotoi
Member
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I notice you are from Florida. Do you believe you were bitten locally or might it have been while you were traveling to the Northeast?

The reason I ask is a recent study by Kerry Clark at the University of Florida identified strains in Georgia and Florida which would would not be caught by a standard Western Blot.

You might reach out to the authors of the paper asking about testing options. The only tests that have a chance of catching distant strains are the C6 or European EUROIMMUN.

C6 fails for some strains plus decays over time. But its available and is an option. EUROIMMUN is not available in the US.

Igenex claims their 2 strain Western Blot has performed well at catching distant strains. If you are unlucky enough to have a distant strain or even species, the standard Western Blot will almost always fail.

Read this paper:

http://www.medsci.org/v10p0915.htm

Posts: 51 | From California | Registered: Aug 2013  |  IP: Logged | Report this post to a Moderator
   

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