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» LymeNet Flash » Questions and Discussion » Medical Questions » MARNIE ~ MAST CELL

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Author Topic: MARNIE ~ MAST CELL
girl
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Marnie ~ Do you know if Lyme is connected with Mast cell disruption (for lack of a better word)? Or mast cell dysfunction to where it creates problems with histamine?

Seems like I remember reading that either Lyme affects the mast cell or gets 'into' it... or something to that effect.

does anyone know?

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Lymetoo
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up for Marnie..

I did find this:

http://geneticgenie.org/blog/2013/01/31/mast-cell-activation-disorder-mcad-chronic-illness-and-its-role-in-methylation/

--------------------
--Lymetutu--
Opinions, not medical advice!

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girl
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Thank you so much, miss Lymetoo! [Wink]
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Robin123
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I just did the 23andme genetic testing and genetic detox slip-ups, or polymorphisms, as they're called, do result in mast cell degranulation dysregulation!

Best thing to do, I think, is get the test done, then get results analyzed through the geneticgenie site and send results on to a doctor who treats people with genetic detox difficulties. I have such a doctor. He said once he sees the obstructed detox pathways, it can be treated for, which is good news.

You're welcome to pm me, Girl, about it.

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Lymetoo
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Robin.. so the 23andme is still going?

--------------------
--Lymetutu--
Opinions, not medical advice!

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Marnie
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I've just requested genetic testing for my son from FSU...most docs don't want to deal with complicated issues...He has ADHD, learning disabilities, seizures (PLP, 50mg Bid stops them), and Asperger's.

Genetic testing is, IMO, very valuable! It is a starting point to try to find "work arounds".

For those of you who have a medical background...it appears my son burns thru B6 - active form is PLP - in order to lower toxic levels of homocysteine.

Instead of recycling homocysteine (3 methyls) to methionine (1 methyl), he breaks homocysteine down to taurine (lowers cholesterol - autism indication), GSH = glutathione and sulfate.

That pathway is called the transsulfuration pathway.

The other pathway is called the remethylation pathway and it uses B9 (= folic acid...yes, I know...MTHFR), B12 and *zinc* dependent - BHMT (an enzyme).

It appears if there is a problem with one pathway to lower homocysteine (the 2 pathways are: transsulfuration and remethylation), the other kicks in to "save us" from toxic levels of homocysteine.

His seizures began at puberty when (in boys especially) homocysteine levels go up...and the need for nutrients to lower homocysteine increases.

Depakote, for HIM, was disastrous. According to a gov. website, it lowers B6 levels AND raises homocysteine.

Now his CT brain scan shows "possible idiopathic hypertension"...which is linked to homocysteine (too high).

We are reversing the damage. It is amazing what PLP (B6), lecithin (choline...to reverse fatty liver), and DMAE (2 methyls) can do for HIM. DHA (with some EPA and vitamin E - formulation i.e., Omega 3 fatty acids) was recently added too because of my AD research.

What does all of this have to do with lyme?

Infections might mimic genetic problem symptoms - or cause us to find out we have underlying genetic situations that hinder our ability to heal.

Infections/toxin exposure - esp. DDT - can make genetic problems worse...primary example is this: DDT-Alzheimer's.

DDT is a pesticide we used (and in some places in the world it is still used),which is still in our environment - water is the biggie because it is going to take a LONG TIME to clear from our water.

And

"DDT mimicks estradiol(E2) stimulation of breast cancer cells to enter the cell cycle."

PMID: 9049186

It appears we store DDT in fat...and women have more fat than men...

Remember the push to wash veggies with a citric acid/vitamin C solution...well, not a bad idea!

http://www.healthy.net/scr/article.aspx?Id=2134 Article about citric acid...scroll down to the mention of DDT.

BTW...men make E2 also (less, but some)...testosterone is converted to E2.

Lymetoo...THANK YOU...THANK YOU...THANK YOU for the link.

DMAE might be doing the trick (his seizure are under control with PLP, his anxiety and depression are MUCH improved with DMAE):

"how to address MCAD with methylation supplements"

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Lymetoo
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You're welcome .. not sure how that link helped!

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--Lymetutu--
Opinions, not medical advice!

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girl
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Thank you Marnie! [Smile] You are always full of such good info.!
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Razzle
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Any ideas for alternatives for Citric Acid/Vitamin C veggie wash?

Citric Acid and Vitamin C both are loaded with sulfites, which I can't do (anaphylactoid...homozygous for CBS upregulation = sulfite sensitivity, plus probably a mast cell issue, though I do not have Mastocytosis)...

Thanks,

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

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Robin123
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Last I heard, people were still doing testing through 23andme, then results get analyzed at another site, the geneticgenie one - guess anyone needs to check with 23andme to make sure they are still doing the testing. I know that they have agreed to comply with FDA requirements and are working on that.
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mlg
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Hi,

I want to chime in I talked to a top researcher and they said lyme + co-infections is directly connected to histamine and leukotrienes.

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Lymetoo
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Thanks, mlg!

Razzle .. I use one by Environne' .. It does contain citrus and GSE though.

I figure that is better than the pesticides??

--------------------
--Lymetutu--
Opinions, not medical advice!

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Lymetoo
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Mast Cells and Pain:

http://www.ncbi.nlm.nih.gov/pubmed/24666768

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 96063 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
   

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