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» LymeNet Flash » Questions and Discussion » Medical Questions » Co-infections = protection attempt?

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Author Topic: Co-infections = protection attempt?
Marnie
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Tapeworms are a rare occurrence in the U.S., but this one surprised me:

"Fish tapeworm and sushi" = *B12 depletion* = increased homocysteine - brain toxic.

B12 is needed in the folate cycle which is part of the *remethylation* cycle (= recycle homocysteine back to methionine). (Not good...so long SAM = depressed.)

ALTHOUGH, to compensate - to lower very dangerous levels of homocysteine - the body may then be

forced to use an alternate pathway:

the transsulfuration pathway may kick in to lower homocysteine which requires B6 (PLP/P5P) and an enzyme called CBS to lower homocysteine...

resulting in the production of taurine (which lowers cholesterol!!!)+ GSH = glutathione + sulfate.

Bb wouldn't like to see cholesterol lowered - esp. the bad forms of cholesterol (!), so theoretically a fish tapeworm infection might be beneficial from that aspect...forcing the transsulfuration pathway -> taurine (lowers LDL), GSH and sulfate.

Bb needs cholesterol(esp. LDL it appears) and D-galactose:

Recent studies by other groups have demonstrated that

Borrelia burgdorferi, B. garinii, and B. afzelii attach a D-galactose molecule to a cholesterol molecule

via β- galactosidic linkage in place of a D-glucose molecule

Put simply, the O-glycoside bond between sugar molecule and sterol molecule in H. pylori differs from the O-glycoside bond between the same two molecules in other organisms.

http://www.scirp.org/journal/PaperDownload.aspx?paperID=28667

Now guess what Candida does to galactose...

Candida abicans contains all the enzymes

necessary for galactose degradation

http://pathway.candidagenome.org/CALBI/NEW-IMAGE?object=GALACTMETAB-PWY

Candida has been found in the temporal lobes of persons with AD (memory)and amyloid beta is considered PROTECTIVE.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907530/

Or

http://www.ns.umich.edu/new/releases/20884-understanding-alzheimer-s-study-gives-insights-into-how-disease-kills-brain-cells

It appears Bartonella (to clear) needs a Th2 immune response and since it appears in Lyme disease, a Th1 response BECOMES prominent - after an initial Th2 response, it is not surprising other infections (that require a Th2 immune response) can perhaps

more easily take hold.

OR...does the body make use of Bartonella to alter/shift the immune response back towards a Th2 response?

Interesting shifts in immune responses also happen during preganancy:

http://www.fuiku.jp/report/deta_22k/22k_02.pdf

It appears the body may also use Hg (mercury) as a protective attempt too (albeit a very bad one!)

Look very closely at what Hg depletes - esp. APOe:

http://www.drdooley.com/mercury-detoxification.php

The APOE gene provides instructions for making a protein called apolipoprotein E.

This protein combines with fats (lipids) in the body to form molecules called lipoproteins.

Lipoproteins are responsible for packaging cholesterol and other fats and carrying them through the bloodstream.

Apolipoprotein E is a major component of a specific type of lipoprotein called

very low-density lipoproteins (VLDLs).

But...

in lipoprotein (VLDL)-induced

foamy macrophages...

In TB infections and others:

The foamy macrophage appears to be a key player in both sustaining persistent bacteria and contributing to the tissue pathology that leads to cavitation and release of infectious bacilli.

PLEASE read my (new) Lyme Vaccine to OspB link.

Posts: 9413 | From Sunshine State | Registered: Mar 2001  |  IP: Logged | Report this post to a Moderator
girl
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reading!
Posts: 631 | From the south | Registered: Nov 2008  |  IP: Logged | Report this post to a Moderator
Razzle
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Interesting! So the infections may make mutations in the methylation pathway more of an issue... Thanks for this - it fits with my own experience...

--------------------
-Razzle
Lyme IgM IGeneX Pos. 18+++, 23-25+, 30++, 31+, 34++, 39 IND, 83-93 IND; IgG IGeneX Neg. 30+, 39 IND; Mayo/CDC Pos. IgM 23+, 39+; IgG Mayo/CDC Neg. band 41+; Bart. (clinical dx; Fry Labs neg. for all coinfections), sx >30 yrs.

Posts: 4166 | From WA | Registered: Feb 2011  |  IP: Logged | Report this post to a Moderator
   

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