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» LymeNet Flash » Questions and Discussion » Medical Questions » Elevated liver enzymes from arteminisin or cat's claw?

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Author Topic: Elevated liver enzymes from arteminisin or cat's claw?
ArtistDi
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Anyone have elevated liver enzymes from either arteminisin or cat's claw?

Never had elevations on IV antibiotics and now I have slight elevation, so trying to figure it out.

Posts: 1565 | From Hatfield, MA, USA | Registered: Mar 2002  |  IP: Logged | Report this post to a Moderator
ArtistDi
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Up
Posts: 1565 | From Hatfield, MA, USA | Registered: Mar 2002  |  IP: Logged | Report this post to a Moderator
seibertneurolyme
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I think the only time hubby ever had elevated liver enzymes was on artemisinin. This happened one or two times when he tried to ramp up on that herb too quickly. The numbers came down pretty quickly.

It has been so long ago I can't remember if we stopped the herb or just decreased the dose. I do know that at times during treatment he took much higher doses of art that did not effect his liver enzymes.

Would not advise taking only art as an herbal babs treatment. It takes combos of herbs just like it takes combos of meds to treat babs.

Bea Seibert

Posts: 7306 | From Martinsville,VA,USA | Registered: Oct 2004  |  IP: Logged | Report this post to a Moderator
TerryK
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Happened to me. Later I found out I had parasites. I think that *could* be why it elevated my liver enzymes. An abundance of die off. Could probably be other reasons as well.
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TerryK
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interesting

http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5831a3.htm
Hepatitis Temporally Associated with an Herbal Supplement Containing Artemisinin --- Washington, 2008

"Elevated liver enzymes have been observed in patients treated for malaria with artemisinins but are generally thought to have resulted from the underlying malaria rather than the artemisinins"

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TerryK
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http://livertox.nih.gov/ArtemisininDerivatives.htm

Mechanism of Injury

The mechanism by which artemisinin derivatives cause liver injury is unknown. Clinical factors and testing for serum antibodies suggest an idiosyncratic immunological reaction to a hepatic metabolite may be responsible. Artemisinin derivatives are extensively metabolized by the liver (primarily via CYP 3A4) and are prone drug-drug interactions if given with strong CYP 3A4 inducers such as rifampin, phenytoin or St. John's wort or inhibitors such as intraconazole or ritonavir.

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seibertneurolyme
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I found an interesting journal article called Resolution of Chronic Hepatitis C Following Parasitosis.

The patient got rid of their chronic hepatitis c by treating Babesia.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250630

Bea Seibert

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Keebler
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What kind of liver support are you doing? Perhaps that might need to be altered.
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Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
Keebler
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http://flash.lymenet.org/scripts/ultimatebb.cgi?ubb=get_topic;f=3;t=030792;p=0

LIVER & KIDNEY SUPPORT & and several HERXHEIMER support links, too.
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Posts: 48021 | From Tree House | Registered: Jul 2007  |  IP: Logged | Report this post to a Moderator
   

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