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» LymeNet Flash » Questions and Discussion » Medical Questions » Borrelia DNA in 5 of 5 Gliomas!

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Author Topic: Borrelia DNA in 5 of 5 Gliomas!
Eight Legs Bad
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Dr Alan Macdonald has found the DNA of Borrelia in an entire series of five brain biopsies from patients with the aggressive brain tumour Glioblastoma multiforme.

https://durayresearch.wordpress.com/our-work/other-topics/glioblastoma-multiforme-borrelia-dna-in-5-of-5-brain-biopsies/

Elena Cook

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Justice will be ours.

Posts: 786 | From UK | Registered: Oct 2007  |  IP: Logged | Report this post to a Moderator
Eight Legs Bad
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Still on the subject of Borrelia and cancer, it's long been known that Borrelia can play a role in causing Lymphoma.

Here's an extract from a very recent Italian study re this (MZL stands for Marginal Zone Lymphoma):

"Role of Borrelia Burgdorferi in Primary Cutaneous B-cell Lymphomas

MZL of the skin has an incidence rate of 1.1/1,000,000 person-years 6 and is predominant among males across all ages. B. burgdorferi (Bb) infection has been associated with skin MZL in some cases in Europe, but not in the U.S., Asia and some parts of Europe, thereby challenging the aetiological role of this agent.153,154

In particular, in Bb endemic areas such as the Scottish Highlands155 or Austria,156 cutaneous

MZL patients have demonstrated Borrelia infection in up to 40% cases, while no association was detected in two Italian case series.157,158 However, in a nonendemic region like France, Bb DNA was found in 19% of 16 cases with primary cutaneous MALT lymphoma.159

Bb infection might be associated with chronic antigen-driven lymphomagenesis in the skin, which is the port of entry of this gram-negative spirochete, through a bite from Ixodid tick and is also the infectious agent of Lyme borreliosis.5,160

Moreover, in late Lyme borreliosis, lymphocytes may infiltrate the dermis and produce the characteristic borrelia “lymphocytoma”, a cutaneous B-cell pseudolymphoma characterized by ‘top-heavy’, mixed-cell lymphoid infiltrate, usually accompanied by the formation of lymphoid follicles with germinal centres.161

Lyme disease and primary cutaneous lymphoma may represent a continuous spectrum of pathological states viewed as a multistep progression from lymphocytoma to “pseudolymphoma” eventually leading to primary cutaneous B-cell Lymphoma, where evidence of B-cell monoclonality may help distinguish between the different stages of the disease.5

Discordant data exist about cutaneous MZL recession after antibiotic treatment of Bb infection (generally consisting of cephalosporins +/− tetracyclines) and are based on case reports.138

In conclusion, Bb and its association with cutaneous MZL are currently the object of investigation, even if an antibiotic treatment may be attempted given the indolent nature of the disease.162"

"the discordant data" could be due to the fact that this is an exceptionally difficult-too-treat infection which sometimes requires long-term IV antibiotics, varying combinations or "pulsed" regimes of abx, etc..in the context of a medical establishment that has been led to believe, wrongly, that 2-4 weeks of standard abx is always curative.

Elena

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Justice will be ours.

Posts: 786 | From UK | Registered: Oct 2007  |  IP: Logged | Report this post to a Moderator
   

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