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» LymeNet Flash » Questions and Discussion » Medical Questions » Is taking nasal steroids considered systemically immunosuppresive?

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Author Topic: Is taking nasal steroids considered systemically immunosuppresive?
ohioperson22
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I'm wondering if 200 micrograms of synthetic glucocorticoids is enough to compromise a lyme patient?

This is a specific question about triamcinolone, which has systemic activity of 70% through the nasal mucosa. (In constrast, fluticasone propionate only has 2% systemic bioavailability from intranasal application).

And what about topical betamethasone for dermatitis?

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Keebler
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Unless a life threatening emergency (and under the care of a LLMD with added protections),

avoid steroids, even topicals and nasal sprays. Even in the sinus cavity, steroids can make lyme in your whole body worse.

There are far better ways to treat nasal issues as well as dermatitis. Even in a skin lotion, it can make lyme in your entire body much worse. It has happened to others and there is not point in taking such a risk. These questions are addressed in articles here:


http://flash.lymenet.org/scripts/ultimatebb.cgi/topic/1/100984?#000000

Topic: what do STEROIDS actually do to those with lyme? Risks, long term damage discussed. Links.
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ohioperson22
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I read that thread, and two things don't make sense:

1. Ashwagandha LOWERS cortisol. Absolutely terrible for someone with critically-low cortisol.

2. The thread says that low dose CORTEF let the adrenals rest? Actually, usage causes a downregulation of endogenous cortisol production, and can suppress the HPTA, as well as cause adrenal atrophy. How do either of those things "help the adrenals rest."???


I'm also interested in scientific literature that 200 micrograms of a synthetic glucocorticoid interfered with the immune response against bacteria.

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Keebler
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http://www.lymenet.de/literatur/steroids.htm

Antibiotics and Steroids - by John Drulle, M.D.

Excerpt:

. . . "Steroid Disaster" is a term coined by the pioneer of Lyme Treatment . . .

Corticosteroids are immune suppressants, the last thing a Lyme patient needs is to lower immunity.
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Keebler
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To answer questions number

1. Ashwagandha lowers cortisol ONLY when the body needs that action. Search: ADAPTOGEN

Many lyme patients have very high spikes of cortisol at times and this can be damaging. Ashwagandha is an adaptogen. Detail as to what that means and to better understand all of it, see Wilson's book and other links in that set.

2. It's all about the PHYSIOLOGICAL REPLACEMENT DOSE and no more - see Wilson's book & also:


Safe Uses of Cortisol by William Jefferies

You can get Wilson's book - and maybe Jefferies, too - through any US library - the interlibrary loan system or through various web vendors.
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TF
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You said:

"I'm also interested in scientific literature that 200 micrograms of a synthetic glucocorticoid interfered with the immune response against bacteria."

Did you look at the Drugs.com entry for this med?

http://www.drugs.com/pro/triamcinolone-nasal-spray.html

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Lymetoo
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What is the trade name of this one?

--------------------
--Lymetutu--
Opinions, not medical advice!

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TF
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Nasacort (Discontinued in U.S.)
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desertwind
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I use it and no problems. My llmd, Dr. H., said not an issue. Now, the 4 months of Dexamethasone I was on....totally different story.
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Lymetoo
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Nasacort is discontinued?

--------------------
--Lymetutu--
Opinions, not medical advice!

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TF
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http://www.medicinenet.com/triamcinolone_acetonide_nasal_inhaler-spray/article.htm
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ohioperson22
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It's not discontinued; its over the counter now in the USA, along with flonase, and even rhinocort.
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randibear
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my llmd said no steroidsin any way shape or form

--------------------
do not look back when the only course is forward

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ohioperson22
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Well, I'd been on Nasocort for 7 years every day.

So I stopped.

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willbeatthis
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I know I had to stop. It seemed even just

occasional use when I had a sinus infection would

really stir the pot (Lyme would begin to flare)

and no doubt my immunity was compromised- 3

infections in a row. That was the only thing I

did differently. I can tell you that Xlear nasal

wash and Pantanase I use daily in allergy season

and have improved greatly. I would add to that

Stinging Nettle (Solgar 1 2x per day) and Super

Quercitin(Bluebonnet) - 2 2x a day has me feeling

normal and I was concerned having to give up the

nasal steroid- seemingly the only thing that would

open me up. Thanks to all here that guided me

on these other options [Smile] Feel better!!

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