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» LymeNet Flash » Questions and Discussion » Medical Questions » Quinoline (plaquenil) vs quinolone what is difference

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Author Topic: Quinoline (plaquenil) vs quinolone what is difference
TxLymie
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I just started plaquenil a week ago and feel terrible . I've never had tendinitis but I suppose that is what I now have in my neck shoulder area. My muscle/tendon is so tight it feels like a guitar strings and pops when massaged. Is plaquenil as dangerous as The FQ drugs? I am on a new abx regimen of plaquenil and clindamycin and feel horrible. I know it could also be a herx but feeling like this is not worth it.

I have been doing pretty well for several years… Back to 90% of my previous health most of the time. I began to experience a little more fatigue recently so went to my LL M.D. who recommended this treatment to hopefully eradicate lyme once and for all.

However now I'm worried that I could have caused permanent damage? Does plaquenil have the same dangers as Levaquin? thoughts?

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TxLymie
IgG-Negative
IgM - Postive bands 23 and 41

Other dx: 2000: Endometriosis 2009: Chronic EBV, Mycoplasma infection, HHV6, H.pylori

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bluelyme
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Hi tx , i dont believe plaq is in the floruidinated drugs ...ther is a list that tutu had ...it does have a extremly long half life like 6 wks and can effect eyes .it is immunosuppressive and may have anti babs cyst busting abilities but maybe try alinia or tinidazole ...?

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Blue

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Judie
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Hydroxychloroquine (plaquenil) is a quinolone.

Fluoroquinolones are a combination of quinolones with fluoride.

The quinolone is one of the problem in fluoroquinolones.

I got refloxed on a plain, old quinolone drug. Ankle swelled up horribly.

Some people believe it's the fluoride that causes the quinolone part to go even deeper into the body.

Personally, I have no problem with fluoride. It's the quinolone part that does me in.

I got horrible problems from both fluoroquinolones (levaquin) and quinolones (primaquine).

Tinidazole also causes peripheral neurapathy and tendon problems. Be careful.

I wish I knew all this before I took any of these.

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TxLymie
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Thanks for the replies! I am still a bit confused though. Is there a difference in quinolones and quinolines. Spelling is almost the same.

And is there any way to tell if the quinolone (Plaq) is causing me issues...or is it a Herx? I already stopped taking plaq because I don't want to take my chances. I also had a lot of heart fluttering today...which is not a normal symptom for me. In fact, I feel so much worse now than when I went to the doc. I was actually not doing that bad but just wanted to knock out the Lyme once and for all but I'd rather just live with the "manageable symptoms" I had than feel like this....I have crazy fatigue, major joint and tendon pain, heart fluttering and can't sleep!

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TxLymie
IgG-Negative
IgM - Postive bands 23 and 41

Other dx: 2000: Endometriosis 2009: Chronic EBV, Mycoplasma infection, HHV6, H.pylori

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Lymetoo
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What quinolINE are you referring to?

http://medical-dictionary.thefreedictionary.com/quinoline

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--Lymetutu--
Opinions, not medical advice!

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SickSam
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I've researched this some more. QuinolINEs are not quinolones. It appears that quinolONEs are quinolINEs. I had it backwards the last time I posted about this. Quinolines are the superclass. Quinolones are the subclass.

See: http://wikidiff.com/quinolone/quinoline

So plaquenil isn't a quinolone, it's a quinoline. I'd venture to say that since they're basically derived from the same stuff though, they both could be harmful.

Also, plaquenil can rarely cause heart issues too.

[ 08-05-2016, 10:35 PM: Message edited by: SickSam ]

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Lymetoo
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NO wonder I can't tolerate either group. It contains a "benzene ring."

I'm pretty sure that is related to salicylates. No phenols or benzoates, etc.

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--Lymetutu--
Opinions, not medical advice!

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