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» LymeNet Flash » Questions and Discussion » Medical Questions » MTRR homozygous

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Author Topic: MTRR homozygous
WPinVA
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Anyone else homozygous for MTRR? ( I am specifically MTRR A664A). From what I am reading, it complicates things --

http://www.mthfrsupport.com.au/mtr-mtrr/

so I would welcome advice from anyone who has already figured this out. thanks!

Posts: 1737 | From Virginia | Registered: Aug 2011  |  IP: Logged | Report this post to a Moderator
sillia
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I think that link describes pretty well how complicated this is -- over methylating as bad as under methylating.

I am hetero for 3 MTRR's. According to my notes this may tend to deplete my B12. I'm also homozygous for MTHFR and have the dreaded CBS +/+. I barely understand any of this, but it does seem like this is one of the factors explaining why I can't get well.

I am just tunneling along, working on this piece by piece as well as I can. I think it is part of my puzzle.

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GretaM
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Hey WP,

I am homozygous for the MTRR mutation also. Aren't we lucky?

I take 15 mg (milligrams, not a typo) of methylcobalamin B12 daily. One tablet under the tongue every morning.

I had to work up to the 15mg.

So far have not noticed an impact in feeling better.

Regards,
Greta

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WPinVA
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Thanks Greta! From what I'm reading, it seems better to start the B12 before the methylfolate.

So are you just taking B12?

Right now I'm taking a multiproduct with both methyl B12 and the folate. But I'm thinking I need to stop that and just do the B12 for a while....

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