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» LymeNet Flash » Questions and Discussion » Medical Questions » Trying to locate study re: how many antibiotics Lyme is resistant to

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Author Topic: Trying to locate study re: how many antibiotics Lyme is resistant to
me
Frequent Contributor (1K+ posts)
Member # 45475

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I could have sworn I read or hear once that over 100 antibiotics don't kill Lyme in a test tube. I'm thinking 130 or something. Does anyone have a link to this research? I can't find it for the life of me.

Thanks.

--------------------
Just sharing my experiences, opinions, and what I've read and learned. Not medical advice.

Posts: 1431 | From USA | Registered: Mar 2015  |  IP: Logged | Report this post to a Moderator
Tincup
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See email I sent so you will have the direct links. Or click on this link to get to the same list with links.

https://sites.google.com/site/marylandlyme/treatment/new-studies-on-drugs-used-in-lab


Identification of novel activity against Borrelia burgdorferi persisters using an FDA approved drug library.
Feng J, Wang T, Shi W, Zhang S, Sullivan D, Auwaerter PG, Zhang Y.
Emerg Microbes Infect. 2014 Jul;3(7):e49. doi: 10.1038/emi.2014.53.
PMID: 26038747 Free PMC Article
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Identification of Additional Anti-Persister Activity against Borrelia burgdorferi from an FDA Drug Library.
Feng J, Weitner M, Shi W, Zhang S, Sullivan D, Zhang Y.
Antibiotics (Basel). 2015 Sep 16;4(3):397-410. doi: 10.3390/antibiotics4030397.
PMID: 27025631 Free PMC Article
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Drug combinations against Borrelia burgdorferi persisters in vitro: eradication achieved by using daptomycin, cefoperazone and doxycycline.
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PLoS One. 2015 Mar 25;10(3):e0117207. doi: 10.1371/journal.pone.0117207.
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Identification of new compounds with high activity against stationary phase Borrelia burgdorferi from the NCI compound collection.
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Persister mechanisms in Borrelia burgdorferi: implications for improved intervention.
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Eradication of Biofilm-Like Microcolony Structures of Borrelia burgdorferi by Daunomycin and Daptomycin but not Mitomycin C in Combination with Doxycycline and Cefuroxime.
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Ceftriaxone Pulse Dosing Fails to Eradicate Biofilm-Like Microcolony B. burgdorferi Persisters Which Are Sterilized by Daptomycin/ Doxycycline/Cefuroxime without Pulse Dosing.
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A Drug Combination Screen Identifies Drugs Active against Amoxicillin-Induced Round Bodies of In Vitro Borrelia burgdorferi Persisters from an FDA Drug Library.
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--------------------
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Posts: 20353 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
susank
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Resistant to or not sensitive to?

I thought I had read that Bb does not become resistant to Abx it is sensitive to.

Don't quote me on that.

(not really sure what you're looking for/asking).

--------------------
Pos.Bb culture 2012
Labcorp - no bands ever
Igenex - Neg. 4 times
With overall bands:
IGM 18,28,41,66 IND: 23-25,34,39
IGG 41,58 IND: 39
Bart H IGG 40

Posts: 1613 | From Texas | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
me
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Thanks so much, Tincup and SusanK. Now that you mention it, SusanK, I'm not quite sure what I'm asking for exactly either. I mean, I do, but I don't.

I think I'm asking how many antibiotics and/or antibiotic
combinations have faileded to kill b. Burgderfori in a test tube? Yes, I think that is what I'm asking. [loco]

--------------------
Just sharing my experiences, opinions, and what I've read and learned. Not medical advice.

Posts: 1431 | From USA | Registered: Mar 2015  |  IP: Logged | Report this post to a Moderator
Tincup
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Bad part in this deal is not that she is nuts, we can accept that.

But I understood what she was saying!

Doesn't say much for me, does it Susank? HA!

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

Posts: 20353 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
me
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[lol] [lol] [lol] Yes, I think I'm saying how many antibiotics and antibiotic combinations total have failed to eradicate b. Burgderfori? Dying to know.

--------------------
Just sharing my experiences, opinions, and what I've read and learned. Not medical advice.

Posts: 1431 | From USA | Registered: Mar 2015  |  IP: Logged | Report this post to a Moderator
Tincup
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The studies will tell you. You'd need to read them as it is over 100 of them. Some only kill the spirochete form, some only kill the other forms. And remember, that is in a test tube.

I remember them all, but I refuse to tell you and make it easy for you unless you send me $22 billion dollars.

How do you like them apples?

[lol]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

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bluelyme
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Tc would you use that money on abx that dont work or other things?

Me , in the summit it was sain lyme had 26 peptides where strep had 5...some believe diflucan makes the efflux pump of spirochete ineffective thus making it succeptable to abx ...
did you have gains on the iv flagyl?

--------------------
Blue

Posts: 1538 | From southwest | Registered: Dec 2015  |  IP: Logged | Report this post to a Moderator
susank
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I'll play.

"me" - you are thinking about something.

What?

Do you know what you want to know and why you want to know it?

--------------------
Pos.Bb culture 2012
Labcorp - no bands ever
Igenex - Neg. 4 times
With overall bands:
IGM 18,28,41,66 IND: 23-25,34,39
IGG 41,58 IND: 39
Bart H IGG 40

Posts: 1613 | From Texas | Registered: Aug 2009  |  IP: Logged | Report this post to a Moderator
Tincup
Honored Contributor (10K+ posts)
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Blue said... "Tc would you use that money on abx that dont work or other things?"

Well, 22 billion dollars buys a LOT of ice cream and the freezers to hold it all, so I'd probably use it on a number of other things.

And besides, I've already spent 1/2 that much on drugs, supplements, OTC items and other things that don't work.

Ice cream is next on the list!

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

Posts: 20353 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
Tincup
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And pizza too!

[Big Grin]

--------------------
www.TreatTheBite.com
www.DrJonesKids.org
www.MarylandLyme.org
www.LymeDoc.org

Posts: 20353 | From The Moon | Registered: Jun 2004  |  IP: Logged | Report this post to a Moderator
me
Frequent Contributor (1K+ posts)
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Okay, you big group of rabble rousers.

Blue--thanks so much for the valuable info.

Tincup-- Are you saying read EVERY study or just the studies you sent (which I did, many thanks again), which would give me a round-a-bout number if I added the drugs from the studies you gave me.

SusanK, Yes, I am asking for a reason. It's a top secret clearance reason. [Wink] Something percolating in my head right now.

Tincup, Should we plan an intervention for your ice cream problem?

--------------------
Just sharing my experiences, opinions, and what I've read and learned. Not medical advice.

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TrekCoord
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Glad that someone put up a link with the info. I tried doing just a google search and it was fruitless.

I am interested in the 26 vs 5 [strep] thing. No wonder ducks don't want to deal with chronic LD - it's too hard and by and large docs don't like hard, they want to solve with one or two meds.

On a side note, I'll take a tithe on the $22 billion!

--------------------
I still have a good time wherever I go!

Posts: 138 | From Lost Wages | Registered: Oct 2016  |  IP: Logged | Report this post to a Moderator
   

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