Of course, especially on a drug like flagy/tindamax or disulfiram which is known to eradicate biofilms and wake up persisters/round body forms...
I've read many lyme patients on the forums report that flagyl and even disulfiram flares their bartonella all the time, I think many lyme patients misuse the word flaring, suggesting that because it's flaring that you're not killing off bartonella.
However, it's very important if you do use flagyl or disulfiram, you should be pairing it up with another bartonella drug... Using either of these solo for bartonella is not enough for bartonella it seems. I think it's quit evident now, that bartonella is the hardest coinfection to eradicate and is probably the main reason why so many lyme patients are staying sick.
I like what Dr. D said in this episode on Better Health Guy, suggesting how we've underestimated the coinfections, the reality seems to be that the coinfections is what seems to be the dominant infection and what Doctors should be concentrating on, I'm paraphrasing of course, but that's what I came away with on her position with this multisystemic disease called Lyme https://youtu.be/937sZJDNVGw
A month ago, I had knocked Bartonella down pretty hard with doxy and pyrazinamide, very few symptoms were left and I felt pretty much normal, then I rotated in with Disulfiram for a week, and what ya know, here comes Bartonella raging back again...
My personal thoughts are, that there's layers upon layers of biofilms in our body. I think as we treat this disease we're pealing the layers back slowly and lowering the bacteria load.
I think I'm going on my 11th year now or so with antibiotics, best I've ever felt, but still battling bartonella.
I suspect that once the new formulated Disulfiram hits the market, it will without a doubt be useful for eradicating borrelia and babesia infections, but bartonella is a whole different ball game, I think from the get go Doctors like Kim Lewis has been underestimating the coinfections and biofilms, I've never heard him mention either of the two. Yet here's one news article saying how severe biofilms are and how it's the main cause of lyme patients being so sick, they were supposed to come out with this new drug Curza that was going to be a big breakthrough for lyme patients https://kutv.com/news/local/utah-drug-research-company-curza-takes-aim-at-lyme-disease
Here we are 5 years later, going on 6, yet still nothing from that Curza company.
I think bartonella isn't just the main reason for keeping lyme patients sick, but an underlying bacterial infection for a lot of other thyroid diseases and disorders, autoimmune disorders, along with mental disorders.
Not sure if you've heard this before, but I'm starting to see this pop up more often now, if it wasn't for AIDs patients, Doctors would perhaps never picked up on Bartonella and realize what a stealthy and deadly pathogen this bacteria can be, especially if you have compromised immune system https://youtu.be/Sz9e-is-UuY?t=235