LymeNet Flash: How To Alleviate Disulfiram Side Effects

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»	LymeNet Flash » Questions and Discussion » Medical Questions » How To Alleviate Disulfiram Side Effects

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Topic: How To Alleviate Disulfiram Side Effects

Bartenderbonnie
Frequent Contributor (1K+ posts)
Member # 49177

posted

Two ILADS members have published the first research paper on how to navigate the side effects of Disulfiram therapy for the treatment of Lyme Disease.

https://www.mdpi.com/2079-6382/12/2/262

Disulfiram is a new weapon in our therapeutic armamentarium (arsenal) used in the treatment of these devastating vector-bone infections, known collectively and colloquially as Lyme disease.

The recent literature has suggested that disulfiram (DSM) may be a potent drug in the armamentarium of physicians who treat chronic Lyme disease. The use of disulfiram in the treatment of Lyme disease started in 2019 with a researcher who determined that DSM is bactericidal to spirochete.

Disulfiram is an old pharmaceutical medication recently re-purposed as a bactericidal antibiotic to treat patients with symptoms of chronic Lyme disease unresponsive to the IDSA-recommended regimen of a two-week course of doxycycline or to the ILADS-recommended regimen of a more prolonged therapy with antibiotics.

Medscape has an excellent article of the toxicity of disulfiram. You must log in to read the full article, it’s FREE!

https://emedicine.medscape.com/article/814525-overview

There are multiple avenues available to alleviate the side effects of disulfiram. They include;

Stopping disulfiram therapy
Glutathione
Sarsaparilla or Similax
Dihydromyricetin (Chinese vine tea)
NAD
Niacin Vitamin B3
R-Lipoic Acid
Melatonin
Desmodium (Burberry)

Posts: 3076 | From Florida | Registered: Nov 2016 | IP: Logged |

Rumigirl
Frequent Contributor (1K+ posts)
Member # 15091

posted

This is not to dissuade anyone from using it, as many people have been helped by it.

BUT it can cause nerve damage, which sometimes goes away with stopping the Disulfiram, but sometimes not. So, if someone does it and they have new, or increased, nerve pain, call your doctor!

Yes, sometimes that could be on the way to improvement, but not always. Frustrating, I know.

Personally, I wouldn't touch it, due to that, but my case is extreme and unusual. But lesser cases of neuropathy are common.

Btw, thank you, Bartender Bonnie for posting all this information!

Posts: 3792 | From around | Registered: Mar 2008 | IP: Logged |

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