LymeNet Home LymeNet Home Page LymeNet Flash Discussion LymeNet Support Group Database LymeNet Literature Library LymeNet Legal Resources LymeNet Medical & Scientific Abstract Database LymeNet Newsletter Home Page LymeNet Recommended Books LymeNet Tick Pictures Search The LymeNet Site LymeNet Links LymeNet Frequently Asked Questions About The Lyme Disease Network LymeNet Menu

LymeNet on Facebook

LymeNet on Twitter




The Lyme Disease Network receives a commission from Amazon.com for each purchase originating from this site.

When purchasing from Amazon.com, please
click here first.

Thank you.

LymeNet Flash Discussion
Dedicated to the Bachmann Family

LymeNet needs your help:
LymeNet 2020 fund drive


The Lyme Disease Network is a non-profit organization funded by individual donations.

LymeNet Flash Post New Topic  New Poll  Post A Reply
my profile | directory login | register | search | faq | forum home

  next oldest topic   next newest topic
» LymeNet Flash » Questions and Discussion » Medical Questions » Best antibiotic treatment for Lyme

 - UBBFriend: Email this page to someone!    
Author Topic: Best antibiotic treatment for Lyme
Areneli
Frequent Contributor (1K+ posts)
Member # 6740

Icon 1 posted      Profile for Areneli     Send New Private Message       Edit/Delete Post   Reply With Quote 
In your personal experience, what is the best antibiotic treatment for Lyme?

If you have truly experienced a meaningful improvement followed by really long relapse free period, or perhaps got cured permanently, tell us about it.


Please try to resist `jokes' in this thread.


Posts: 1538 | From Planet Earth | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
Kara Tyson
Frequent Contributor (5K+ posts)
Member # 939

Icon 1 posted      Profile for Kara Tyson         Edit/Delete Post   Reply With Quote 
I like Zithromax.

***
Now a question for you, what is it with the "please resist jokes"? Seems an odd thing to add...


Posts: 6022 | From Mobile, AL | Registered: Apr 2001  |  IP: Logged | Report this post to a Moderator
Areneli
Frequent Contributor (1K+ posts)
Member # 6740

Icon 1 posted      Profile for Areneli     Send New Private Message       Edit/Delete Post   Reply With Quote 
Kara,
Thanks for your input. Can you elaborate if possible on Zithromax?
How long taken, how much, how long improvement lasted?


PS
I simply want this thread to stay focused


Posts: 1538 | From Planet Earth | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
Areneli
Frequent Contributor (1K+ posts)
Member # 6740

Icon 9 posted      Profile for Areneli     Send New Private Message       Edit/Delete Post   Reply With Quote 
This thread is depressing: no good experiences with antibiotics.

Perhaps the doctors who believe that chronic Lyme cannot be cured are right and we all are just wasting resources for expensive antibiotics that do not work.

[This message has been edited by Areneli (edited 18 January 2005).]


Posts: 1538 | From Planet Earth | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
ConnieMc
Frequent Contributor (1K+ posts)
Member # 191

Icon 1 posted      Profile for ConnieMc     Send New Private Message       Edit/Delete Post   Reply With Quote 
IMO, Minocycline is the best for neuro-Lyme. It has improved my cognitive status lots. But I cannot take it too many days in a row, or I get dumb as a rock. I take it on a few off a few or every other day.

[This message has been edited by ConnieMc (edited 18 January 2005).]


Posts: 2274 | From NC | Registered: Oct 2000  |  IP: Logged | Report this post to a Moderator
Beverly
Frequent Contributor (5K+ posts)
Member # 1271

Icon 1 posted      Profile for Beverly     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi Areneli,

Melanie has a wonderful post on "Success Stories"..do a search under her name. Lots of people have gotten better with abx treatemnt!

For myself I think the two years on doxy and Mino really helped the lyme and now treatment for Babesia, Zithromax, Plaquenil and Malarone has gotten me to the point of feeling mentally well.

Good luck to you.


Posts: 6626 | From Michigan | Registered: Jun 2001  |  IP: Logged | Report this post to a Moderator
Kara Tyson
Frequent Contributor (5K+ posts)
Member # 939

Icon 1 posted      Profile for Kara Tyson         Edit/Delete Post   Reply With Quote 
Aren,

I guess all I can say is that Zithromax has always worked for me. And I have never had a side effect to the drug. The main drawback is the cost.

I usually take 1500 mg every 2 weeks.

I have been in remission twice over the past 5 years. The longest improvment has lasted is about a year.


Posts: 6022 | From Mobile, AL | Registered: Apr 2001  |  IP: Logged | Report this post to a Moderator
hatsnscarfs
LymeNet Contributor
Member # 6562

Icon 1 posted      Profile for hatsnscarfs     Send New Private Message       Edit/Delete Post   Reply With Quote 
Tetracycline seems to be working for me. I'm taking 1,500 mgs/day (750+750) and making steady, noticable progress. I'm having very few side effects. It is much easier on me than Doxy and more effective. I'm on my 7th week of tetra.

Doxycline 200mgs a day was not enough. After 4 months I was getting worse and I was naseous much of the time. I improved dramatically within days of switching to tetra.

I'm seeing Dr. D. in Boston, you can read his paper on tetracycline (and other drugs)http://www.canlyme.com/donta.html. He suggests that tetracycline may work better that some other drugs simply because you can take a lot more of it. I think this is true in my case. I don't think I could have tolerated doubling or tripling my doxycycline dose.

Knock, knock... (oops, sorry)
h&s


Posts: 956 | From MA | Registered: Nov 2004  |  IP: Logged | Report this post to a Moderator
HaplyCarlessdave
Frequent Contributor (1K+ posts)
Member # 413

Icon 1 posted      Profile for HaplyCarlessdave   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
Several combinations were tried for me. The mainstay of my treatment was: 6 g amoxicillin + 1 g clarithromycin('biaxin'...) per day (divided morning-evening).
But what really did the trick was attacking babesia with 'malarone' (atovaquone in solid form) and artimesia/artimisinin, and garlic concentrate, and raw. Every combi of abx, and herb, I took did somerhing to help- not sure how much I can really isolate "one thing that did it". But I made the most progress on the amoxicillin-clarithromycin.
I also took, at the same time, grapefruitseed extract 25 drops once or twice a day. and also olive leaf estract, 250 ml twice a day. And vitamins and supplements of various sorts.
I had quite a "herx" with ..'ceftin' + doxy (1g/400mg), and at first it seemed hard on the gut- but that may also have been a "herx".
I was on treatment for around 2 years. Now. ayear and a half or so later, so far so good, and abx-free!
DaveS

[This message has been edited by HaplyCarlessdave (edited 18 January 2005).]


Posts: 4567 | From ithaca, NY, usa | Registered: Nov 2000  |  IP: Logged | Report this post to a Moderator
chainsaw joseph
LymeNet Contributor
Member # 6611

Icon 1 posted      Profile for chainsaw joseph     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hatsandscarfs is there any way I can get in touch with you,I also just started with Dr D about 5 weeks ago with tetra.I also have made a little improvement.
Posts: 308 | From new bedford,Ma. | Registered: Dec 2004  |  IP: Logged | Report this post to a Moderator
beachcomber
Frequent Contributor (1K+ posts)
Member # 5320

Icon 1 posted      Profile for beachcomber     Send New Private Message       Edit/Delete Post   Reply With Quote 
IV Rocephin gave me the most improvement. Then, treatment for Babesiosis (Mepron) is clearing up the imbalance issues and hypotension. IM Bicillin is now the Rx that is maintaining me at a functional level.
Posts: 1452 | Registered: Feb 2004  |  IP: Logged | Report this post to a Moderator
christelleny
LymeNet Contributor
Member # 6719

Icon 1 posted      Profile for christelleny     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi Areneli,

I'm about where you are: still researching doctors and treatments. In the process, I went through much medical research and compiled a list of antibiotics choices for Lyme Disease (I figured I might as well be informed when I finally meet my LLMD). I've emailed you the list.

As a rule of thumb, remember all antibiotics are either bacteriostatic (inhibit the growth of the bacteria) or bactericid (kill the bacteria). From what I've read, chronic/advanced stage Lyme doesn't respond to one class of antibiotic alone, but to a combination of antibiotics. Each and every patient will respond differently to a same combination, so knowing what worked for others is unlikely to help you. There are hundreds of antibiotics to chose from (hence the importance given to a doctor's experience and knowledge).

Besides antibiotic treatment, there is a serious need for:

1) Antibacterial therapy
2) Inflammtion and Immune System therapy
3) Protecting the nervous system from neurotoxins
4) Detoxyfying the body

(a good LLMD will be able to go over that with you and make recommendations on diet and supplementation)

PS: you can check http://www.nextmd.com
for more info on common drugs, side effects and interactions with other drugs.


Posts: 159 | From CT, USA | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
Areneli
Frequent Contributor (1K+ posts)
Member # 6740

Icon 1 posted      Profile for Areneli     Send New Private Message       Edit/Delete Post   Reply With Quote 
If somebody can report a successful combination of antibiotics that worked for them, please let us know as well.

Please also provide doses and length of treatment. It is very important. Some treatments with too low doses or that are too short, do not work.

With my limited experience I have used Augmentin 3x 1g with small success (small herx reaction) but really started herxing when one week later increased Amoxicillin to 4.5 g per day. I may even soon consider going higher to 6 g/day.

I have read many general writings on Lyme treatment. What I couldn't find were the specifics: exact combinations of antibiotics, exact doses, exact time of treatment and sequences. Anybody feel that so called pulse therapy had helped them?

As I have mentioned there was no LLMD in my province; but what is to my advantage I have a lot o medical education behind me and perhaps can figure out a few things without LLMD.
Currently I know a lot more about Lyme disease then the doctors who treat me.
Presently they just follow my hints but I am often lost and need help. The official medicine is not providing many tips for successful treatments. There were very few clinical trials on Lyme treatment in the past and not much is going on presently.
So it appears that the Internet thanks to your personal experiences is one of the best sources of knowledge.
Thanks for your sharing.


Posts: 1538 | From Planet Earth | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
treepatrol
Honored Contributor (10K+ posts)
Member # 4117

Icon 1 posted      Profile for treepatrol     Send New Private Message       Edit/Delete Post   Reply With Quote 
What your asking is hard to answer because of time and combinations of abx's I believe they all contribute to getting better but first your going to get worse lots of ups and downs.
Each combo of abx's works differently on indviduals Bb strains, coinfections, how long you have had it etc.
Theres no magic bullit yet.

Posts: 10564 | From PA Where the Creeks are Red | Registered: Jun 2003  |  IP: Logged | Report this post to a Moderator
liz28
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
Doing much better on ketek, omnicef and low dose mino.
IP: Logged | Report this post to a Moderator
hatsnscarfs
LymeNet Contributor
Member # 6562

Icon 1 posted      Profile for hatsnscarfs     Send New Private Message       Edit/Delete Post   Reply With Quote 
Chainsaw Joseph,
I just saw your post. Sure you can get in touch with me. Email me at [email protected] then I'll email you my phone #.
h&s

Posts: 956 | From MA | Registered: Nov 2004  |  IP: Logged | Report this post to a Moderator
zipzip
LymeNet Contributor
Member # 6226

Icon 1 posted      Profile for zipzip     Send New Private Message       Edit/Delete Post   Reply With Quote 
quote:
Originally posted by Areneli:
If somebody can report a successful combination of antibiotics that worked for them, please let us know as well.

Please also provide doses and length of treatment. It is very important. Some treatments with too low doses or that are too short, do not work.


you have to remember that there are many variables to Lyme treatment.

*how long has the person been sick and how high is their bacterial load?

the higher the bacterial load the higher doses of abx that are needed as well as duration of treatment.

*what is the person's immune status?

immunoglobulin testing is very important and usually not done. IgG and IgG sublevels 1,2,3,4 and total IgA.

if a person is immunodeficient they will create idiopathic antibodies and not be able to eradicate the borrelia antigen with just antibiotics, immunomodulating drugs will be needed.

*borrelia strains and pharmacokinetics of antibiotic.

western blotting looks for the strain borrelia burgdoferi (and in europe afzelli and garinii). yet there are over 300 known strains of borrelia.

you will never, by contemporary testing ability, know which strain you probably have unless you are 100% unequivocal positive for borrellia burgdoferi.

different strains have different susceptibility to different antibiotics, and in turn each antibiotic has differnet pharmacokinetics which work on the borrelia antigen.

since borrelia can mutate and evade the humoral host often different antibiotics are necessary.

the borrelia antigen has three different known forms - spirochete, cell wall deficient (L-form) and cyst form. each form calls for the need of a different antibiotic.

the borrelia spirochete enzyme also contains beta-lactams so a beta-lactam (penicillin derived) antibiotic must be in high enough dosages to be effective.

i think the majority of people do well by combining beta-lactam bactericidal drugs with intracelluar bacteriostatic drugs of the macrolide class like zithromax.

anecdotal evidence shows many people have positive responses to sulfur based antibiotics (septra/bactrim) which have a very long half life.

*co-infections.

if found in the patient must be treated. erichliosis cannot be treated with beta-lactam drugs so a month of a cycline antibiotic must be used.

babesia is a protozoan so antimalarial drugs must be used in combination with an intracelluar drug to be successful.

bartonella is often treated as a result of treating Lyme but rifampin is the best treatment with a minimum of one month. the cycline antibiotics are effective on bartonella as well.

sorry, but nothing is clean cut. check out the following article by tom grier :
http://www.canlyme.com/tom.html

[This message has been edited by zipzip (edited 24 January 2005).]


Posts: 795 | From nyc | Registered: Sep 2004  |  IP: Logged | Report this post to a Moderator
giftoflife
Member
Member # 6748

Icon 12 posted      Profile for giftoflife     Send New Private Message       Edit/Delete Post   Reply With Quote 
hatsandscarfs & chainsaw

My son is a patient of Dr. D/ Been seeing him since 10/04. Son was diagnosed in September after 5 months of getting the run around. Has been hard but Dr. D is making it easier. Just saw him last week. Have nothing but good things to say about him. I'm willing to "talk" to. We're from WMASS.


Posts: 30 | From MA | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
duramater
LymeNet Contributor
Member # 6480

Icon 1 posted      Profile for duramater     Send New Private Message       Edit/Delete Post   Reply With Quote 
hey gift:

just saw your post. i'm in western ma too w/o LLMD although too sick to travel. can you contact me too? want to talk about doc et al.

thanks
~dm
([email protected])


Posts: 689 | From western MA (we say buttER and pizzA) | Registered: Nov 2004  |  IP: Logged | Report this post to a Moderator
David95928
Frequent Contributor (1K+ posts)
Member # 3521

Icon 1 posted      Profile for David95928     Send New Private Message       Edit/Delete Post   Reply With Quote 
My experience with long-term Bicillin and Biaxin has been very positive. I had been infecterd and untreated at east twelve years and was really starting to deteriorate fast. At this point, after two years, I've been able to return to all normal activities except heavy weightlifting. I have been.literally, building a house. Also, other than herxing, I've had no side effects. In my opinion, it's a great combination, simple and shown to have been helpful to may people here.
David

Posts: 2034 | From CA | Registered: Jan 2003  |  IP: Logged | Report this post to a Moderator
lymiecanuck
Unregistered


Icon 1 posted            Edit/Delete Post   Reply With Quote 
I have not been treated long enough yet or but my experience with what I have tried is biaxin with amoxillian gave me the fastest improvements and had herxs with it. It was 1000mg of biaxin and 2000mg of amoxiallain. I was extremely ill when i went on and started feeling a lot better in a couple of weeks.

Doxy didn't agree with me.

I am on probenicid and amoxy now and seeing some improvements but feel I need something with more kick.

Lymiecanuck


IP: Logged | Report this post to a Moderator
chainsaw joseph
LymeNet Contributor
Member # 6611

Icon 1 posted      Profile for chainsaw joseph     Send New Private Message       Edit/Delete Post   Reply With Quote 
giftolife,is there anyway we can get in touch with you?Heres my adress [email protected] if you want,same for you duramater will answer anything I can.
Posts: 308 | From new bedford,Ma. | Registered: Dec 2004  |  IP: Logged | Report this post to a Moderator
IBelieve
Member
Member # 6834

Icon 1 posted      Profile for IBelieve     Send New Private Message       Edit/Delete Post   Reply With Quote 
quote:
Originally posted by chainsaw joseph:
giftolife,is there anyway we can get in touch with you?Heres my adress [email protected] if you want,same for you duramater will answer anything I can.

Sorry, first post. I don't know if I am doing this right. I am also going to see Dr D. in Boston.


Posts: 48 | From New Hampshrie | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
Hikin Mike
Member
Member # 6508

Icon 1 posted      Profile for Hikin Mike   Author's Homepage     Send New Private Message       Edit/Delete Post   Reply With Quote 
I've only been on antibiodics since October. Had ~6 weeks on IV Rocephin and just finished 8 weeks on oral Zithromax. I've noticed a big improvement since being on Zithromax. I don't need my cane anymore, but my knees are still swollen and sore.

I'm also being given IV Gammaglobin (sp?) once a month to boost my immune system. That is probably helping as well.

------------------
-Mike


Posts: 96 | From Atwater, Ca | Registered: Nov 2004  |  IP: Logged | Report this post to a Moderator
cmichaelo
LymeNet Contributor
Member # 5873

Icon 1 posted      Profile for cmichaelo     Send New Private Message       Edit/Delete Post   Reply With Quote 
Minocycline has been the only abx out of a total of three (Doxy, Zith and Mino) that I've seen improvement with.

I would even call the neuro improvements significant.

I just added Amoxycillin (3 weeks ago.) Have not seen any effects yet.

There is a 4 year old thread on this topic, and still going strong btw, with 100's of responses to your question: http://flash.lymenet.org/ubb/Forum1/HTML/000323.html

Michael


Posts: 702 | From NY | Registered: Jul 2004  |  IP: Logged | Report this post to a Moderator
Areneli
Frequent Contributor (1K+ posts)
Member # 6740

Icon 1 posted      Profile for Areneli     Send New Private Message       Edit/Delete Post   Reply With Quote 
I have read it and also brought it up recently (check the last dates if you wish) but it was not popular.


Treatments do change with new research and experience so it is important to know what is out there and what works the best at present, not 4 years ago.

[This message has been edited by Areneli (edited 26 January 2005).]


Posts: 1538 | From Planet Earth | Registered: Jan 2005  |  IP: Logged | Report this post to a Moderator
2bostons
LymeNet Contributor
Member # 6249

Icon 1 posted      Profile for 2bostons     Send New Private Message       Edit/Delete Post   Reply With Quote 
Hi

I am seeing huge improvements in my LD symptoms with weekly bicillin injections and probenecid...

cathy


Posts: 125 | Registered: Sep 2004  |  IP: Logged | Report this post to a Moderator
   

Quick Reply
Message:

HTML is not enabled.
UBB Code is enabled.

Instant Graemlins
   


Post New Topic  New Poll  Post A Reply Close Topic   Feature Topic   Move Topic   Delete Topic next oldest topic   next newest topic
 - Printer-friendly view of this topic
Hop To:


Contact Us | LymeNet home page | Privacy Statement

Powered by UBB.classic™ 6.7.3


The Lyme Disease Network is a non-profit organization funded by individual donations. If you would like to support the Network and the LymeNet system of Web services, please send your donations to:

The Lyme Disease Network of New Jersey
907 Pebble Creek Court, Pennington, NJ 08534 USA


| Flash Discussion | Support Groups | On-Line Library
Legal Resources | Medical Abstracts | Newsletter | Books
Pictures | Site Search | Links | Help/Questions
About LymeNet | Contact Us

© 1993-2020 The Lyme Disease Network of New Jersey, Inc.
All Rights Reserved.
Use of the LymeNet Site is subject to Terms and Conditions.