posted
Celebrex?? I took it many years ago. Not anymore. Don't wanna die!
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 94761 | From Texas | Registered: Feb 2001
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HEATHERKISS
Frequent Contributor (1K+ posts)
Member # 6789
posted
Huh? Die? why?
-------------------- HEATHER
Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005
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liz28
Unregistered
posted
I've been on it about five years. It lowers your systemic inflammation. If you are concerned about side effects, you could try it at a lower dosage.
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HEATHERKISS
Frequent Contributor (1K+ posts)
Member # 6789
posted
My husband is really sick. I think he got a virus on our vacation to Memphis.
Now every Lyme symptom is coming out. He's using phrases like, I'm dieing.
or I feel like I was beat up with a bag of rocks.
or who's stabbing me? (reffering to shoulder blade pain)
The LLMD saw him today and prescribed celebrex for 10 days.
Our flippin insurance didn't cover it. So we are out of pocket for the LLMD and the rx.
Another happy Lyme story. Do you hear the sarcasm in my voice?
Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005
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Celebrex, a closely related drug also made by Pfizer, from the class of pain relievers known as Cox-2 inhibitors, will be allowed to remain on the market. But it will be forced to carry strict new warnings alerting doctors and patients that it elevates the risk of heart attacks and strokes, the FDA says.
-------------------- Peggy
~ ~ Hope is a powerful medicine. ~ ~ Posts: 2775 | From MN | Registered: Apr 2001
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"Inhibition of cyclooxygenase and prostaglandin E2 synthesis by gamma-mangostin, a xanthone derivative in mangosteen, in C6 rat glioma cells.
Nakatani K, Nakahata N, Arakawa T, Yasuda H, Ohizumi Y.
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, 980-8578, Sendai, Japan.
The fruit hull of mangosteen, Garcinia mangostana L., has been used for many years as a medicine for treatment of skin infection, wounds, and diarrhea in Southeast Asia. In the present study, we examined the effect of gamma-mangostin, a tetraoxygenated diprenylated xanthone contained in mangosteen, on arachidonic acid (AA) cascade in C6 rat glioma cells. gamma-Mangostin had a potent inhibitory activity of prostaglandin E2 ( PGE2) release induced by A23187, a Ca2+ ionophore. The inhibition was concentration-dependent, with the IC50 value of about 5 microM. gamma-Mangostin had no inhibitory effect on A23187-induced phosphorylation of p42/p44 extracellular signal regulated kinase/mitogen-activated protein kinase or on the liberation of [14C]-AA from the cells labeled with [14C]-AA. However, gamma-mangostin concentration-dependently inhibited the conversion of AA to PGE2 in microsomal preparations, showing its possible inhibition of cyclooxygenase (COX). In enzyme assay in vitro, gamma-mangostin inhibited the activities of both constitutive COX (COX-1) and inducible COX (COX-2) in a concentration-dependent manner, with the IC50 values of about 0.8 and 2 microM, respectively. Lineweaver-Burk plot analysis indicated that gamma-mangostin competitively inhibited the activities of both COX-1 and -2. This study is a first demonstration that gamma-mangostin, a xanthone derivative, directly inhibits COX activity."
PMID: 11754876 [PubMed - indexed for MEDLINE] 4: Mahabusarakam W, Proudfoot J, Taylor W, Croft K.
-------------------- --Lymetutu-- Opinions, not medical advice! Posts: 94761 | From Texas | Registered: Feb 2001
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Lymelighter
Frequent Contributor (1K+ posts)
Member # 5310
posted
Heather, I use to take it but swicthed to Sulindac, an old school NSAID. It worked better for me w/out the worry.
Posts: 1010 | From Mars | Registered: Feb 2004
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HEATHERKISS
Frequent Contributor (1K+ posts)
Member # 6789
posted
It's not working for my husbands pain!!!!!!!!!!!!
Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005
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HEATHERKISS
Frequent Contributor (1K+ posts)
Member # 6789
posted
Etodolac is another old school nsaid. This is new pill Bill is going to take.
-------------------- HEATHER
Posts: 1974 | From ABERDEEN, NJ 07747 | Registered: Jan 2005
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posted
Hi Heather, I have been so sick lately. Times you feel like you are dying or from the inside out very slowly. After yrs. of mis-dxes spending moocho bucks & savings could use now. Had a life,fam,business,friends,big home,boat, etc. Now living on basically nothing but my last of savings to provide roof over my head, daily needs.
I am unable to get proper treatment my primary believes but will not treat, say lack of knowledge. Heck after 5 yrs. think he would study up, know I am not his 1 and only Lyme,FM,cfids,MS/++ patient. Yet he is only 1 on my insurance that does believe enough to take me on with band aid treatment.
I am so sorry, know about the pain 24/7/fatigue/nausea/ days I wake say I belong in hosp. or nursing care too sick to take care myself. On my own here, no fam. close.
It is hard to watch for others being on other end in med. field prior.
It is hard just try to do your best to get a laugh or keep up his spirits, how lucky he is to have some support (from you I gather).
Clebrex, hmmmm we had the research people for 3 yrs. at our clinic.
Find being in & part of they listen to only what they want making research,testing not reliable depending how much they want to get it approved.
Only listen to good.
So always when you see studies, as told when young believe only 50% of what you read. Sort out rest yourself. More energy,work for us who do not have.
Celebrex has done wonders for some. That I know,long term. Think many these new meds being shoved at us.
Why not go to the old proven ones.
Even hard to get old fashion peniciilan. It does work for many. Cheap, prob. why???
Hang in there not easy on either end for sure...
Kerry
Posts: 746 | From Clearwater/fl/Pinellas | Registered: Jun 2003
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