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» LymeNet Flash » Questions and Discussion » Medical Questions » Lyme vaccine for mice

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Author Topic: Lyme vaccine for mice
shazdancer
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Researchers have developed an oral vaccine that reduces carriage of Borrelia burgdorferi in mice and protects against Lyme disease.

"Lyme disease is caused by the spirochete Borrelia burgdorferi, which is transmitted through the bite of infected Ixodes ticks. Vaccination of mice with outer surface protein A (OspA) of B. burgdoiferi has been shown to both protect mice against B. burgdorferi infection and reduce carriage of the organism in feeding ticks. Here we report the development of a murine-targeted OspA vaccine utilizing vaccinia virus to interrupt transmission of disease in the reservoir hosts, thus reducing incidence of human disease," scientists writing in the journal Vaccine report.

"Oral vaccination of mice with a single dose of Vaccinia expressing OspA resulted in high antibody titers to OspA, 100% protection of vaccinated mice from infection with B. burgdorferi, and significant clearance of B. burgdorferi from infected ticks fed on vaccinated animals," said Mark R. Scheckelhoff and colleagues, Tufts University. "The results indicate the vaccine is effective and may provide a manner to reduce incidence of Lyme disease."

Scheckelhoff and his coauthors published their study in Vaccine (Protective efficacy of an oral vaccine to reduce carriage of Borrelia burgdorferi (Strain N40) in mouse and tick reservoirs. Vaccine, 2006;24(11):1949-1957).

Additional information can be obtained by contacting Linden T. Hu, Tufts-New England Medical Center, Tupper Research Institute, Division of Geographic Medicine and Infectious Diseases, Box 41, 750 Washington Street, Boston, MA 02111, USA. [email protected]

Posts: 1558 | From the Berkshires | Registered: Jul 2001  |  IP: Logged | Report this post to a Moderator
wrotek
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Who is the hero and will try it first [Smile]

I remember that Lymerix was also OspA based vaccine and it made people very sick or even contracting Lyme disease.


What a pitty mouse can't tell if it feels sick.

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johnlyme1
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At least all the mice will be healed
Posts: 582 | From milwaukee wi | Registered: May 2005  |  IP: Logged | Report this post to a Moderator
shazdancer
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The hope is that if field mice can be vaccinated, then they won't get Lyme, can't transmit it to ticks, and ticks won't transmit it to people.

It won't help current patients, but might help the rest of the country.

Regards,
Shaz

Posts: 1558 | From the Berkshires | Registered: Jul 2001  |  IP: Logged | Report this post to a Moderator
Truthfinder
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Very interesting, but I sure won't voluteer for any Lyme vaccine!

This all sounds good, but how long did they observe the mice after the vaccine was given? Sometimes these studes are cut short and no one knows the long-term effects.

Tracy

--------------------
Tracy
.... Prayers for the Lyme Community - every day at 6 p.m. Pacific Time and 9 p.m. Eastern Time just take a few moments to say a prayer wherever you are.

Posts: 2966 | From Colorado | Registered: Dec 2005  |  IP: Logged | Report this post to a Moderator
   

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