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» LymeNet Flash » Questions and Discussion » Medical Questions » marnie- magnesium advice?

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Author Topic: marnie- magnesium advice?
danielb
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hi, sorry only if you (marnie) or someone else has time and wants to, i don't mean to give you more work. i am trying to work out a doable plan for short term magnesium replacement (to going on to as long term as i am capable of.)

i have bad cognitive problems so need to know what magnesium protocol is most likely to show results fast. the problem is i cannot remember to take my medication after a while, i have too many down periods where i cannot remember a single thing, and live in a place where i hoard so medication is frequently hard to find, and i forget during the finding process. believe it or not, i try really hard. i have bad akathisia, and movement issues, which has been said to be helped by B6, wonder if that is a relation to magnesium already in the body.

1. MAG- currently, the best magnesium i have available is 250mg magnesium citrate and 265mg malic acid. is this idea or do i need straight magnesium malate?

2. B6- do i need one of the "p5p" or more complicated types?

3. B12(methyl)- would this help? it helps nerve regen in bell's palsy. i have suspected my uneven face before. (droopy eyebrow and the way my lip sits sometimes on the same side, uncannily noticable during periods fatigue/stress)

4. SELENIUM- this was on the list you made, i think. how does it help? are certain formulations of questionable safety (as with chromium?)

5. OTHERS that could give a boost to the process? make it quicker, or more substantial?

(6. and 7. added below in other post.)

sorry for odd format, i don't have much of a brain the way things are.

[ 19. February 2007, 01:52 AM: Message edited by: danielb ]

Posts: 244 | From Ottawa | Registered: Dec 2005  |  IP: Logged | Report this post to a Moderator
Meg
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daniel,
I'm going to bump your post up.

You might do a search under Marnie's name for your specific questions....that may get you an answer much sooner. [Smile]

--------------------
Success Stories---Treatment Guidelines

Posts: 10010 | From somewhERE OVER THE Rainbow | Registered: Oct 2000  |  IP: Logged | Report this post to a Moderator
danielb
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thank you. i'll try. having lots of problems reading a lot, but it is worth a shot.

additionally i wonder if taurine has any use augmenting magnesium replacement. (it is an anticonvulsant? caclium channel blocker?) gah, i really have to make an ideal mix. i am currently off abx since i cannot remember to take them. i am trying memantine, but my hypersomnolence is getting worse, i have 4 only slightly functional hours tops during the day. (basically enough for my dad to come and see me and bring me for food, which i am lucky for.)

oops, so adding:

6. TAURINE and GABA, etc.- does taurine or any other possible natural anticonvulsants boost magnesium replacement and/or block calcium?

7. MSG, ASPARTAME - does eliminating their intake really help? do they really cross the blood brain barrier into the nervous system? if so, are there other toxic ingredients to watch out for? are natural glutamates in certain foods a worry? (like with mushrooms?)

[ 19. February 2007, 12:01 PM: Message edited by: danielb ]

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LymeLaura
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My doctor recommended at least 500 mg of magnesium/day. I take the magnesium glycinate (Doctor's Best) form. The citrate bothers my tummy.

While I was on high dose amoxicillin/bactrim, I took up to 1000 mg/day (split in doses).

If you are having trouble rememembering to take pills, some pharmacies have pill holders that also have timers for up to 4 to 5 doses per day. It worked great for my Dad who had Parkinsons and had to take pills every two hours.

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danielb
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thank you for responding. do you think the magnesium benefitted you?
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MrG
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daniel...absolutely avoid msg & aspertame. Natural or bound glutamate normally is not a problem UNLESS cooked too long or processed. But absolutely try to avoid 'free glutamate'. Mushrooms are high in bound glutamate. Please see the list I posted here:

http://flash.lymenet.org/ubb/ultimatebb.php?ubb=get_topic;f=1;t=050353

I take taurine in pure form. Stops my seizures & other msg induced symptoms. Yes it is a
anticonvulsant & calcium channel blocker.

I don't recommend mag citrate. It has citric acid in it. I take mag orotate in pure form & is the best absorbable.

I have a interview this coming sunday with Carol Hoernlein, Founder MSGTruth.org & a Korean documentary team about the adverse effects of msg. I'll let you all know how I made out.

--------------------
Pat Sr

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Marnie
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KNOW the potential dangers of Mg citrate IF (!) you are currently on Rxs:

http://www.drugs.com/cdi/Magnesium_Citrate_Solution.html

I am concerned about (excess) aluminum issues. Aluminum binds to citrates. Aluminum displaces Mg. This is serious stuff!

Here are some innate protective factors that are TRYING to help:

"In the blood, plasma transferrin steals both Fe3+ (iron) and Al3+ (aluminum) from citrate."

http://lib.bioinfo.pl/meid:113156

So if aluminum is bound to citrate, transferrin will "steal it away". Follow?

Citrates INactivate PFK. Bb is "PFK dependent".

Lactoferrin ALSO binds aluminum.

Supposedly ALA helps "chelate" aluminum too. (Protein/acids/negative charges binding to a mineral with a positive charge.)

"A principal way that aluminum appears to express toxicity is that it replaces magnesium ions at critical target sites in the cell.

chemically, aluminum is quite similar to magnesium... aluminum can compete effectively for magnesium binding sites in biological systems... aluminum binding to ATP is 7 to 10 times stronger than magnesium, so even at very low concentrations (nanmolar) aluminum can potentially interfere with magnesium-dependent systems..." Berthoff, pp 250

However, activity is restored in the presence of citrate because citrate binds aluminum 20 times more strongly than ATP. (The Lancet, Oct. 29, 1988, p.1008)"

"Aluminum follows the iron pathway in the extracellular environment in being bound to the iron transport proteins transferrin and lactoferrin.."

"A possible connection exists between aluminum and acetylcholine deficiency. Research shows that aluminum inhibits cholinergic activity.

Compounds used in antiperspirants may inhibit synaptic *uptake* of dopamine, norepinephrine and 5 hydroxytryptamine. Aluminum has also been shown to inhibit ***Na-K-ATPase*** and hexokinase. These are critical enzymes for energy metabolism.

Parkinsonism dementia and amyotrophic lateral sclerosis are neurodegenerative diseases that are endemic among Guamanian and Kii Peninsula Chamorro Indians and are characterized by neurofibrillary tangles.

These endemic diseases have epidemiological features that strongly indicate that environmental factors may play an important role.

The soils of these areas are particularly rich in aluminum and iron,

while deficient in calcium and magnesium.

There are indications that aluminum increases parathyroid activity that reduces calcium levels and causes calcium to be withdrawn from brain tissue. The loss of brain calcium may be the major cause of Alzheimer's disease.

Mayor and coworkers reported that increased parathyroid hormone activity can increase intestine and brain absorption of aluminum.

Dialysis patients, in particular, display increased fractures when their drinking water is high in aluminum and low in calcium. The exact mechanism for the mineralization problem is unknown. It appears that aluminum affects the activity of alkaline and acid phosphatase and modifies the response of these enzymes to parathyroid hormone and vitamin D.

The calcium/aluminum connection could help explain why other biochemical imbalances which interfere with calcium metabolism - lead poisoning, phosphates in soda pop, copper imbalance, manganese deficiency which affects thyroid function, etc., could contribute to the causation of Alzheimer's disease.

http://www.arltma.com/AlzheimerDoc.htm

What's happening...too friggin much aluminum and iron in relationship to Ca and Mg.


Aluminum INHIBITS Na-K-ATPase and *hexokinase*.

The body will use aluminum when Mg drops to try to stop glycolysis. Both Hexokinase and phosphofructokinase are enzymes needed in the steps for glycolysis. Hexokinase is first.

Remember above...aluminum inhibits hexokinase.

Mg is really needed all the way thru the glycolysis pathway. Aluminum looks to try to halt this...thus maybe starving the cells of glycogen to fuel the mitochondria?

Scroll down to the bottom of this website to see the enzymes controlling glycolysis:

http://www.rpi.edu/dept/bcbp/molbiochem/MBWeb/mb1/part2/glycolysis.htm

Regarding selenium:

Type in "selenium TNF alpha" into a search engine...you will quickly see why.

"Selenium supplements contain selenium in different chemical forms.

In the majority of supplements, the selenium is present as selenomethionine.

However, in multivitamin preparations, infant formulas, protein mixes, weight-loss products and animal feed, sodium selenite and sodium selenate are predominantly used.

In some products, selenium is present in protein- or amino acid chelated forms; in still others, the form of selenium is not disclosed.

Current evidence favors selenomethionine over the other forms of selenium.

Extradietary supplementation of selenium at the dosage of 200 micrograms per day is generally considered safe and adequate for an adult of average weight subsisting on the typical American diet.

http://www.jacn.org/cgi/content/full/20/1/1

IL 1 beta is the bigger problem!

Sure looks to me like products like Juvenon (NAC, ALA and biotin) and lactoferrin might help...a lot.

Can't let Al "sub" for Mg. Once again, it looks like another imbalance...too much Al and Fe and too little Ca and Mg. (Ca is our most abundant mineral and will be pulled from storage - bones).

Too much aluminum in use in our environment. We don't have the ability to handle/control this excess, IMO.

Ginkgo will help you to think more clearly and so will cocoa. When I was young, for breakfast my mom would make me hot chocolate from scratch. She used 1 heaping tablespoon of cocoa powder (it tastes bitter), 2 teaspoons of sugar, a dash of salt and a little water. She brought this to a boil, stirring constantly and then added a cup of milk, warming it to the right drinkable temperature. It is the flavonoids in cocoa powder that are so powerful (vasodilation is what I am talking about).

On a "better day" try to understand the above. I know it is pretty complex.

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