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» LymeNet Flash » Questions and Discussion » Medical Questions » Interpreting Test Results

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Author Topic: Interpreting Test Results
Hiawatha922
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I've had a couple of Lyme tests over the past few months. I was wondering if anyone could help interpret a few items from these tests. On the first test (Elisa), this note is included in the results:

"Lyme Confirm IgG WB Negative Band(s) present:
41 kDa (insufficient number of bands for a positive result)". 0 bands present on IgM.

On the second test (Western Blot), p24 is listed as "1" (a weak positive). However, 41 is not even listed--all of the others are "0".

What is the significance of these results?

I'm planning to see an LLMD for the first time in a few weeks but I wanted to check in on this information. Any comments would be appreciated. My symptoms include: right leg weakness, left arm tingling, tingling in left side of back, tingling on left temple, fatigue, occasional vertigo, and muscle/joint aches.

I believe that if I am infected with Lyme, it probably occurred years ago (while in college?)
I am now 44 years old.

Posts: 83 | From Minnesota | Registered: Dec 2006  |  IP: Logged | Report this post to a Moderator
Hiawatha922
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I appreciate the responses from those of you who commented on my earlier post regarding Band 41. So far, my doctors have simply dismissed all results as "negative".
Posts: 83 | From Minnesota | Registered: Dec 2006  |  IP: Logged | Report this post to a Moderator
Lymetoo
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WEll, in my opinion....those test results don't have any significance. The ELISA is useless and any lab other than IGENEX or maybe MDL [for lyme testing] is worthless.

Sorry to be so negative, but it's true.

Dr. Bransfield's Reason's for Seronegativity the reasons why you can test negative and still have Lyme disease.

1. Recent infection before immune response
2. Antibodies are in immune complexes
3. Spirochete encapsulated by host tissue (i.e.: lymphocytic cell walls)
4. Spirochete is deep in host tissue (i.e.: fibroblasts, neurons, etc.)
5. Blebs in body fluid, no whole organisms needed for PCR
6. No spirochetes in body fluid on day of test
7. Genetic heterogeneity (300 strains, 100 in U.S.)
8. Antigenic variability
9. Surface antigens change with temperature
10. Utilization of host protease instead of microbial protease
11. Spirochete in dormancy phase (L-form) with no cell walls
12. Recent antibiotic treatment
13. Recent anti-inflammatory treatment
14. Concomitant infection with babesia may cause immunosuppression
15. Other causes of immunosuppression
16. Lab with poor technical capability for Lyme disease
17. Lab tests not standardized for late stage disease
18. Lab tests labeled "for investigational use only"

19. CDC criteria is epidemiological not a diagnostic criteria
20. Lack of standardized control
21. Most controls use only a few strains as reference point
22. Few organisms are sometimes present
23. Encapsulated by glycoprotein "S-layer" which impairs immune recognition
24. "S"- layer binds to IgM
25. Immune deficiency
26. Possible down regulation of immune system by cytokines
27. Revised W.B. criteria fails to include most significant antigens

=========================

I do hope others will respond here!

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 94879 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
Hiawatha922
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Just a clarification. Band 41 was marked as "present" on that first test.
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Lymetoo
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I hope you get more replies than mine. I'm not the authority on this, that's for sure!! [Wink]

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 94879 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
Lymetoo
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up

--------------------
--Lymetutu--
Opinions, not medical advice!

Posts: 94879 | From Texas | Registered: Feb 2001  |  IP: Logged | Report this post to a Moderator
bpeck
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I agree with Lyme too.
Band 21-24 is outer surface protein C - very highly specific to Lyme. Being weakly positive, means you just didn't have enough antibodies to that protein the be called 'positive' - but they were there-

Alot of people don't have *any* antibodies when they get initially tested- for the very reason's listed in the previous post.

Here's waht I did - asked my doc doc to try 30 days of Doxycycline. Then stop, then wait 5 weeks- then get tested again - then I did PCR with the western blot... I was positive by PCR with a high spirochete load.- but negative western blot. (I later turned positive by western blot when my antibody production finally got in gear).

I'd say with your symptoms- and that blot- you have lyme.
Barb

Posts: 1873 | From VT | Registered: Oct 2002  |  IP: Logged | Report this post to a Moderator
   

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